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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by rovers95 on October 31, 2006, at 11:39:05
went up to 25 mg last night and wow i feel even better today...i mean lyk loads more chilled out!!! hope this holds-if anyone hasnt tried this for a hyperactive, irritable depression i wud give it a bash-its defo doin sumthin 4 now+i have been preety irresponsive to the ssris and tricyclics!!!
mark
Posted by ronaldo on October 31, 2006, at 14:37:27
In reply to WOW!!LAmictal is working for me!!!, posted by rovers95 on October 31, 2006, at 11:39:05
> went up to 25 mg last night and wow i feel even better today...i mean lyk loads more chilled out!!! hope this holds-if anyone hasnt tried this for a hyperactive, irritable depression i wud give it a bash-its defo doin sumthin 4 now+i have been preety irresponsive to the ssris and tricyclics!!!
>
> markGlad you're feeling so good on it, Mark. What dosage did you start on and how long altogether have you been on it? Do you take anything else? I am considering getting my pdoc to prescribe some Lamictal for me. I am a long term Lithium user (like 25 years long) and I want something to combat the flat affect. I also suffer from 'hyperactive, irritable depression'. In my case I think it might be a mixed episode/mood. I am Bipolar. At the moment it is well controlled by 10 mg Olanzapine. I have used Olanzapine for the past four years at 5 mg. Then I came off it, gradual taper... I tried Seroquel for sleep which did not work for me and had to go back on the Olanzapine at 10 mg. My sleep seems to be coming right just in the last few days (touch wood) after a total of 14 days. Has Lamictal had any influence on your sleep? What therapeutic dose are you aiming to get to? I tried amitryptiline, trazodone, and prozac all for about four months each without any relief from my depression/early awakening.
Rather a lot of questions.....I can't stop once I get started. I would really be grateful if you can supply some answers.
....Alan
Posted by rovers95 on October 31, 2006, at 20:04:51
In reply to Re: WOW!!LAmictal is working for me!!! » rovers95, posted by ronaldo on October 31, 2006, at 14:37:27
> Glad you're feeling so good on it, Mark. What dosage did you start on and how long altogether have you been on it? Do you take anything else? I am considering getting my pdoc to prescribe some Lamictal for me. I am a long term Lithium user (like 25 years long) and I want something to combat the flat affect. I also suffer from 'hyperactive, irritable depression'. In my case I think it might be a mixed episode/mood. I am Bipolar. At the moment it is well controlled by 10 mg Olanzapine. I have used Olanzapine for the past four years at 5 mg. Then I came off it, gradual taper... I tried Seroquel for sleep which did not work for me and had to go back on the Olanzapine at 10 mg. My sleep seems to be coming right just in the last few days (touch wood) after a total of 14 days. Has Lamictal had any influence on your sleep? What therapeutic dose are you aiming to get to? I tried amitryptiline, trazodone, and prozac all for about four months each without any relief from my depression/early awakening.
>
> Rather a lot of questions.....I can't stop once I get started. I would really be grateful if you can supply some answers.
>
> ....Alan
>
>hi, wel i started last week on 12.5mg and after 1 week have gone up to 25mg (should have bin 2 but i cheated!) at such a low dose, dont think its a problem (seen as the starter pack they give to neuroligists starts at 50mg!)i am aiming to stay at this dose for two weeks and then titrate up again to 75mg and then 100mg after 6 weeks (hopefully by this time i will be out of the woods for the "rash"!) i will work my way up (maybe even further) and see how i feel until i have gone above my max therapeutic dose!! Think bi-polar target dose may be even higher, but some people get good results at low doses!!
It has effected my sleep in the way that i no longer have nightmares and racing thoughts, today i woke up 10 hours later feeling rested!
i really think my glutamate system is out of wack, due to an intaractable magnesium deficiency which also leaves me with fatigue. Recent studies have shown ketamine to be extremely effective for depression (treatment resistant) by its NMDA antagonist effects.
Although ketamine is not available (for obvious reasons!) lamictal appears to inhibit glutamate and help normalise the HPA axis although it is not a direct NMDA antagonist, im also going to try the low affinity NMDA antagonist memantine (off hand) when i have found my maximum results on lamictal!!!
From what i have read on remedyfind.com bi-polar many people seem to be having great results with it.even better than unipolar depressive people. BTW we are not really sure wot i am but i definetly suffer from anxious hyperactive depression!!
Archived posts on here have also suggested that lamictal and lithium are the perfect match and some have suggested lamictal is just good on its own-guess every1s different so trial and error is the only way forward!!
i am taking SJW and rhodiola wioth minimal results (but hoping lamictal will boost these!). One thing i have found really helpful is l-theanine, as from what i gather have many bi-polars...so might be worth a try?!
hope this can help....also got a bit of a roll with all the info!!!
mark
Posted by Phillipa on October 31, 2006, at 23:40:59
In reply to Re: WOW!!LAmictal is working for me!!!, posted by rovers95 on October 31, 2006, at 20:04:51
Just follow your doc's instrutions on titrating up as it's not safe to titrate faster. And It's wonderful that you feel so well. Love Phillipa
Posted by rovers95 on November 1, 2006, at 9:08:47
In reply to Re: WOW!!LAmictal is working for me!!!, posted by rovers95 on October 31, 2006, at 20:04:51
Hey, feelin gud today.i just have a damn headache!!! Ibuprofen aint doin the job eitha!!! Any ideas?????
mark
Posted by Basia on November 1, 2006, at 11:56:59
In reply to WOW!!LAmictal is working for me!!!, posted by rovers95 on October 31, 2006, at 11:39:05
That is fantastic! It works for a lot of people, I hear. Worked for me for ages.
Posted by rovers95 on November 1, 2006, at 17:29:08
In reply to Re: WOW!!LAmictal is working for me!!!, posted by Basia on November 1, 2006, at 11:56:59
> That is fantastic! It works for a lot of people, I hear. Worked for me for ages.
At what dosage did u find you best results.....im not in remission but im defo better!!! Only went to 25mg on mon....maybe i wil get further improvements!! did it just "poop" out on you??? If you had any other experiences whilst in lamictal to share with me i would be very grateful-this seems like it might be a promising journey for me!!
mark
Posted by tensor on November 2, 2006, at 4:51:08
In reply to WOW!!LAmictal is working for me!!!, posted by rovers95 on October 31, 2006, at 11:39:05
Hi,
at what dosage are you currently at? This is my third day at 100mg as a mood stabilizer/AD augmentor. The first and the second day i felt an improvement in my mood, but now it's gone, i wonder when lamictal's antidepressant effect usually kicks in. I've used the 25/25/50/50/100(mg) titration regime.
Posted by rovers95 on November 2, 2006, at 8:18:54
In reply to Re: WOW!!LAmictal is working for me!!! » rovers95, posted by tensor on November 2, 2006, at 4:51:08
> Hi,
>
> at what dosage are you currently at? This is my third day at 100mg as a mood stabilizer/AD augmentor. The first and the second day i felt an improvement in my mood, but now it's gone, i wonder when lamictal's antidepressant effect usually kicks in. I've used the 25/25/50/50/100(mg) titration regime.Im just at 25mg and will go up to 50 in about 10 days time.....hell i had some bad anxiety last nyt though-u experienced any of that?!Apparently the dosage is different for everyone-i read somewhere some people (mostly bi-polars i think) dont get an adequate response till 600mg whereas others get an AD effect at 25mg!!!
What are u takin it with???im on SJW and theanine w/ a bit of rhodiola aswell-tryin 2 limit my meds!!u got any libido changes-im hopin for a big boost!!mark
Posted by tensor on November 2, 2006, at 9:17:41
In reply to Re: WOW!!LAmictal is working for me!!!, posted by rovers95 on November 2, 2006, at 8:18:54
It does something for my libido, i'm thinking about sex more now than before, i don't if the "performance" is better yet. I have problems with recurring treatment resistant unipolar depression(i also have problems with long dx names), i take 100mg nortriptyline, 15mg remeron and 2mg clonazepam(for SP/GAD). When/if lamictal kicks in i gonna try to remove one of the AD's above. An attempt to limit number of meds.
No anxiety for me, but i have been nauseous for a few days after each dose raise. I also have difficulties falling asleep./Mattias
Posted by tensor on November 2, 2006, at 15:14:21
In reply to Re: WOW!!LAmictal is working for me!!!, posted by rovers95 on November 2, 2006, at 8:18:54
myself>i don't if the "performance" is better yet.
Well i actually just tested it and it was much better already, it's like it's counteracting the sexual s/e from nortrip :-)
/Mattias
Posted by rovers95 on November 2, 2006, at 17:19:14
In reply to Re: WOW!!LAmictal is working for me!!! » rovers95, posted by tensor on November 2, 2006, at 15:14:21
> myself>i don't if the "performance" is better yet.
>
> Well i actually just tested it and it was much better already, it's like it's counteracting the sexual s/e from nortrip :-)
>
> /Mattias
>
> Yeah that is great stuff....to be honest thats been the last thing on my mind recently-but now im getting better!!! Must be the dopamine thing i think-through a sort of indirect effect on the NMDA receptors!! I read someone hailing it as the new viagra somewhere..but also other stories of reduction in libido, no change 4 me as of yet!!Stick l-theanine beside and see if it increases its effectiveness......its workin for me, i read lamictal increases the antidepressant effects of ketamine+seen a l-theanine also seems to have NMDA antagonist properties this kinda adds up!!
I no wot your sayin about to many meds-not really sure what all my herbal stuff is doing to me anymore!!
mark
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