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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by iforgotmypassword on September 25, 2006, at 15:50:39
(NOTE: *NOT* asking how to get an unapproved med; simply asking if it is technically-speaking available anywhere.)
buspirone seems odd in its dopaminergic effects, specifically anti-dopaminergic effects. it seems to be well known as a D2 blocker. but it may also be a PRESYNAPTIC dopamine AUTOreceptor AGONIST, which is even spookier.
it also may be indirectly anticholinergic. (whew!)
buspirone at high dose worsens parkinson's symptoms.
this is awkward... i want to try low doses anyway, but given how i get the extrapyramidal pseudoparkinsonian signs from SSRIs and even spontaneously (may be a lyme effect) i worry heavily.
i also am a hoarder, and have severe apathy/amotivation/concentration problems so anticholinergic effects scare me that way too.
gah.
anyone have any NEW news on gepirone? any new signs of life?
Posted by iforgotmypassword on September 25, 2006, at 16:04:11
In reply to buspar properties; gepirone available anywhere?, posted by iforgotmypassword on September 25, 2006, at 15:50:39
maybe i should have put this with my other post.
sorry, i am a bit scattered and having to force my way through posts and in order to express myself, more than even my usual, today. why is my head full of cement all the time?! gar.
Posted by linkadge on September 25, 2006, at 18:49:31
In reply to arg. sorry for being messy., posted by iforgotmypassword on September 25, 2006, at 16:04:11
Yeah, I too would like to know if gepirone will ever come to see the light of day.
Linkadge
Posted by yxibow on September 27, 2006, at 9:53:10
In reply to buspar properties; gepirone available anywhere?, posted by iforgotmypassword on September 25, 2006, at 15:50:39
> (NOTE: *NOT* asking how to get an unapproved med; simply asking if it is technically-speaking available anywhere.)
>
> buspirone seems odd in its dopaminergic effects, specifically anti-dopaminergic effects. it seems to be well known as a D2 blocker. but it may also be a PRESYNAPTIC dopamine AUTOreceptor AGONIST, which is even spookier.
>
> it also may be indirectly anticholinergic. (whew!)
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=6123570&query_hl=26&itool=pubmed_docsum
>
> buspirone at high dose worsens parkinson's symptoms.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=3026624&query_hl=26&itool=pubmed_docsum
>
> this is awkward... i want to try low doses anyway, but given how i get the extrapyramidal pseudoparkinsonian signs from SSRIs and even spontaneously (may be a lyme effect) i worry heavily.
>
> i also am a hoarder, and have severe apathy/amotivation/concentration problems so anticholinergic effects scare me that way too.
>
> gah.
>
> anyone have any NEW news on gepirone? any new signs of life?An NDA was filed for Gepirone by Fabre Kramer, who took it from Organon, in 2006. Its possible marketed name may be Veriza / Ariza.
http://www.fabrekramer.com/products.html
As for BuSpar -- it is a failed antipsychotic used as an anxiolytic so it does have some of those properties. Only about 1/3 of the people respond for anxiolytic relief on it.
On the other hand it has been used, albeit with pseudoparkinsonism, in experimental treatments against TD in astronomical amounts of it.
At the regular doses the main thing I felt was some faintness / lightheadedness.-- Jay
Posted by psychobot5000 on September 28, 2006, at 23:38:04
In reply to buspar properties; gepirone available anywhere?, posted by iforgotmypassword on September 25, 2006, at 15:50:39
I have heard no new news, but the word was, last time I heard, that the FDA had rejected gepirone applications, and the rationale for reapplying seemed poor.
However, a 5HT-1a agonist of another sort, PRX-00023 recently finished (sept 21 06) a stage 3 trial for GAD. Possibly due in part to larger-than-expected placebo response, the study failed to show a statistically significant trend in favor of prx-00023, though an insignificant one was there. BUT...
The secondary goal of the study showed positive results (statistically significant, too) for patient ratings on the MADRS scale. So it seems to be effective for depression--it is in phase 2 for depression, and the developer plans to regear development toward that indication. It is likely to be better tolerated, with fewer side-effects, than the buspirone-type meds. We may see it on the market in a year or two.
http://news.pajamasmedia.com/health/2006/09/21/10962844_EPIX_Pharmaceuti.shtml
Posted by iforgotmypassword on October 1, 2006, at 23:33:48
In reply to Re: buspar properties; gepirone available anywhere » iforgotmypassword, posted by yxibow on September 27, 2006, at 9:53:10
> At the regular doses the main thing I felt was some faintness / lightheadedness.
>
> -- Jay
>
>good to know all that, thank you. also good to know of your S/E experience. i have been having a hard time with that, so much i couldn't hold my handwriting steady in front of someone yesterday, when i was signing up for a local election window sign. it was annoying, but it is good to know that it might not be from my aricept with it now being at 10mg. i was drooling spontaneously a bit lately, so i thought it could be cholinergic effects, but now i think it is the buspar. looking back, like many drugs, i have just felt drunker and more tired since starting it. on the upside bruxism is slightly down, but i still do it. other benefits i anticipated are nowhere to be seen as of yet.
This is the end of the thread.
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