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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by JahL on August 23, 2006, at 1:27:14
Hello people.
Right, I'm gonna try and keep this relatively brief (but keep in mind brevity is rather alien to me); the sun is already rising here in England and I have a long day ahead of me.
Aaaaanyway. This morning I found an old batch of sublingual Buprenorphine that had been lying around for a number of years. In a fit of WTF-ed-ness, I popped a couple of 0.2mg tabs under my tongue and.....I feel pretty good. Relatively speaking.
Some questions:
1/ Does anyone have an idea of what the optimal dose *might* be for a depressed individual who is relatively opioid-naive? The literature talks of seemingly heroic doses of up to 16mg, but I imagine this would be for opioid-tolerant persons (ie poor heroin addicts). In the past I have taken Methadone and peak effects were experienced at a mere 5ml (1mg:1ml), and sustained for many years.
2/ How often should one take it? The literature describes a mean half-life of 37 hours and so I imagine (correctly??) once daily dosing would be sufficient?
3/ Are there any tolerance issues related to Buprenorphine administration?
So what effect does this drug have on me? Good question. Essentially, it's a decidedly mellow, dreamy sensation; rather subtle but also rather pleasant. I note that Bupe mimics the effects of full opioid agonists, but possesses a limited ceiling quality.
My particular 'brand' of (*pernicious*) Bipolar is characterised by, amongst other things, agitation, anger and chronic violent ideation. These feelings have largely dissipated, which can only be a good thing. I haven't had a suicidal thought in the last two hours - a record for me. The AD effect is subtle, but discernable.
The word that perhaps best captures the experience is 'serenity' (aaahh :-)
I could wax lyrical but it's getting late and I don't want to hex this experience. I don't doubt this post will pique some interest in one or two Babble-types and I promise I will return with a progress report.
Please, no opiophobic comments; obviously I do not come here to be preached at (this request is prompted by previous discussions here). Just be happy for me that as I write this, I am more relaxed than I have been for many a year. Please.
Thanks for any help proffered.
What was I saying about brevity?
G'night all,
Jah.
Posted by Tom Twilight on August 23, 2006, at 1:52:13
In reply to Thoughts on BUPRENORPHINE., posted by JahL on August 23, 2006, at 1:27:14
Hey Jamie
Its your Stalker!
Seriously though I've been wondering about using Buprenorphine for Social Anxiety, although I've no idea how get hold of it.
There isn't much info on this......Opiates do seem to do something special for Social Anxiety and depression.
The much vaunted Benzo's just flatten me out, and don't make me very sociable.Poppy pod extract is the only serious opiate I've tried, although unfortunatly this has all the issues of tollerance e.c.t.
I believe Buperorphine has most of the issues associated with other Opiates, just to a lesser degree.
Hopefully I'm wrong.A last thought is that a super powerful Kratom extract-7-hydroxymitragynine
Has just been released, supposedly as powerful as other opiates.Just some thoughts really
Sorry if this is a little incoherent, its first thing in the morning for me to!Have you got any of my emails?
Posted by JahL on August 23, 2006, at 2:15:27
In reply to Re: Thoughts on BUPRENORPHINE., posted by Tom Twilight on August 23, 2006, at 1:52:13
Hi Tom.
> Have you got any of my emails?
Sh!t. I completely forgot to register a new email address. That's ETC for you! I *promise* I'll register my hotmail account by 8pm tonight. I really hope you've sent copies of your emails to your inbox.
I'd like to address some of your points, but the Seroquel is kicking in and my bed beckons...
Speak to you tomorrow, and again, apologies for my laziness/forgetfulness.
Nite,
J.
Posted by Meri-Tuuli on August 23, 2006, at 3:55:48
In reply to Thoughts on BUPRENORPHINE., posted by JahL on August 23, 2006, at 1:27:14
Hiya
You might want to search the archives for psuenoname (I'm not sure I spelled that correctly!) I think he was taking bupe just recently and was doing very well on it (hence his possible absence these days).
Yeah, I think he was doing very well on it and really liked it. He managed to get a pdoc to prescribe it. I think even he himself was relatively surprised at how well it was going.
Just a thought.
Kind regards
Meri
Posted by Phillipa on August 23, 2006, at 11:09:32
In reply to Re: Thoughts on BUPRENORPHINE., posted by Meri-Tuuli on August 23, 2006, at 3:55:48
They're using it in Charlotte to detox people But I don't know a thing about it? Love Phillipa
Posted by JahL on August 23, 2006, at 13:53:58
In reply to Thoughts on BUPRENORPHINE., posted by JahL on August 23, 2006, at 1:27:14
In all my 30 years, I've *never* experienced proper remission. So life *is* worth living after all. All I can say is WOW!
As my dopehead friends might say, this is THE SH*T!
Thanks for responses; will answer when I'm not so busy enjoying my new lease of life!
Full update to follow.
Be well, people. All of you.
New and improved Jah. :-)
Posted by JahL on August 23, 2006, at 16:07:06
In reply to Re: Thoughts on BUPRENORPHINE., posted by Tom Twilight on August 23, 2006, at 1:52:13
Posted by Tom Twilight on August 23, 2006, at 16:58:24
In reply to Tom, check your email. (nm) » Tom Twilight, posted by JahL on August 23, 2006, at 16:07:06
Sorry I've really dragged this thread of topic!
Anyone like to say more about Buprenorphine?
Posted by free_electron on August 26, 2006, at 11:53:32
In reply to Thoughts on BUPRENORPHINE., posted by JahL on August 23, 2006, at 1:27:14
Hi Jah,
> 1/ Does anyone have an idea of what the optimal dose *might* be for a depressed individual who is relatively opioid-naive? The literature talks of seemingly heroic doses of up to 16mg, but I imagine this would be for opioid-tolerant persons (ie poor heroin addicts). In the past I have taken Methadone and peak effects were experienced at a mere 5ml (1mg:1ml), and sustained for many years.
If you're going down the bupe road I suggest you use whatever minimum dose works for you. 0.2 mg sounds reasonable for a non-habitual opiate/opioid user.
> 2/ How often should one take it? The literature describes a mean half-life of 37 hours and so I imagine (correctly??) once daily dosing would be sufficient?Technically 1/day is enough
> 3/ Are there any tolerance issues related to Buprenorphine administration?
Yes. So try to stick to whatever mimimum dosage works for you. Getting off long-term buprenorphine use is in my experience far more painful than getting off heroin.
Good luck
Peter
This is the end of the thread.
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