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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Maxime on August 3, 2006, at 14:23:02
Hi
Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
Does anyone know?
Thanks.
Maxime
Posted by SLS on August 3, 2006, at 14:32:23
In reply to Reboxetine .... was it banned?, posted by Maxime on August 3, 2006, at 14:23:02
> Hi
>
> Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
>
> Does anyone know?
To the best of my knowledge, reboxetine simply failed to produced successful clinical studies to submit to the FDA.
- Scott
Posted by silvercoin on August 3, 2006, at 16:45:38
In reply to Re: Reboxetine .... was it banned?, posted by SLS on August 3, 2006, at 14:32:23
> > Hi
> >
> > Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
> >
> > Does anyone know?
>
>
> To the best of my knowledge, reboxetine simply failed to produced successful clinical studies to submit to the FDA.
>
>
> - Scott
My doctor has used Strattera, another NRI, extensively, and related to me at my last appointment that his observation is that it does not seem to produce a robust antidepressant response. I wonder if some amount of serotonin reuptake blockade is required in combination with the NE reuptake blockade. Desipramine is selective for NE reuptake but also has a relatively low dissociation constant for blockading serotonin reuptake in human cells, between 10 and 100, I believe.Todd
Posted by Maxime on August 3, 2006, at 19:45:04
In reply to Reboxetine .... was it banned?, posted by Maxime on August 3, 2006, at 14:23:02
Thanks both.
Someone on another group told me it was banned. I thought it was because of what Scott said, but wasn't sure.
I tried Strattera ... all it did make make me pukey. Not pleasant. I have emetophobia.
maxime
Posted by Racer on August 4, 2006, at 1:43:06
In reply to Re: Reboxetine .... was it banned?, posted by Maxime on August 3, 2006, at 19:45:04
> I have emetophobia.
>
> maxime
>
>LoL Maxie, I spent all morning and part of the afternoon at the ER with my husband, because he can't be sick without going to hospital... I guess I can tell him the name now...
(In his defense, he was being sick because he had a migraine...)
I'm sorry you didn't do well with Strattera. It did help me a bit, although I was way too anxious on it, waaaaaaaaaaaaayyyyyyyyyyyyy too agitated/anxious/fragile/etc.
How about tianepine? That's the one I'd like to try. Is it available in Canada? Just a thought...
Posted by snapper on August 4, 2006, at 2:38:01
In reply to Re: Reboxetine .... was it banned?, posted by SLS on August 3, 2006, at 14:32:23
> > Hi
> >
> > Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
> >
> > Does anyone know?
>
>
> To the best of my knowledge, reboxetine simply failed to produced successful clinical studies to submit to the FDA.
>
>
> - ScottMaxime, Scott is correct. It is available in the UK. The right Dr. and Script will get it to you. It sadly just did not pass US scrutiny and "standards". Fight for what ever you think you need and will help you. My pdoc , 6 to 7 years ago was more than happy to RX a script for it.
I think you live in Canada, correct if wrong. It is alive and is considered an SNRI-- it did'nt do a lot for me...but you know the rule...it could be exactly what you need. Press on and let any of us know if we can help!
Snapper
Posted by SLS on August 4, 2006, at 6:40:09
In reply to Re: Reboxetine .... was it banned? » SLS, posted by snapper on August 4, 2006, at 2:38:01
Hi Snapper!
Regarding reboxetine...
> It is alive and is considered an SNRI
That was its original designation until it was usurped by authors who wanted to use it to name drugs like Effexor and Cymbalta. Now reboxetine is called a NARI.
SNRI (Old) = Selective Norepinephrine Reuptake Inhibitor
SNRI (New) = Serotonin Norepinephrine Reuptake Inhibitor
NARI = Noradrenaline Reuptake Inhibitor
Of course, "noradrenaline" is a term used primarily in the UK, while "norepinephrine" is the term favored in the US. I wonder what would happen if a NARI were to come to market in the US. Would we then have a NERI?
NOKHTHIW = No One Knows How The Hell It Works
- Scott
Posted by Maxime on August 4, 2006, at 23:24:28
In reply to Re: Reboxetine .... was it banned? » Maxime, posted by Racer on August 4, 2006, at 1:43:06
It the only reason I never started purging my food. A blessing in disguise ... or so I am told.
No, Tianepine isn't available in Canada. I want to try it.
Maxime
> > I have emetophobia.
> >
> > maxime
> >
> >
>
> LoL Maxie, I spent all morning and part of the afternoon at the ER with my husband, because he can't be sick without going to hospital... I guess I can tell him the name now...
>
> (In his defense, he was being sick because he had a migraine...)
>
> I'm sorry you didn't do well with Strattera. It did help me a bit, although I was way too anxious on it, waaaaaaaaaaaaayyyyyyyyyyyyy too agitated/anxious/fragile/etc.
>
> How about tianepine? That's the one I'd like to try. Is it available in Canada? Just a thought...
Posted by Racer on August 5, 2006, at 1:06:56
In reply to Re: Reboxetine .... was it banned? » Racer, posted by Maxime on August 4, 2006, at 23:24:28
>
> No, Tianepine isn't available in Canada. I want to try it.
>
> Maxime
>
What do you say, then? You speak French, don't you, and it's available there? Maybe we should take a nice vacation to Paris for an adequate trial period, say three months? ;-)Wouldn't that be nice?
I know. That doesn't help. Pfinstegg was taking tianepine, though, so there is a way of using it in the US. Can you look up the mechanism for getting it in Canada, and then talk to your doctor?
I've got an appointment in September to talk to a new psychopharmacologist, and will ask about it myself.
Take care of my Canadian friend, won't you?
Posted by Maxime on August 5, 2006, at 17:22:02
In reply to Re: Reboxetine .... was it banned? » Maxime, posted by Racer on August 5, 2006, at 1:06:56
Yes I speak French and a trip to France would be lovely.
In terms of obtaining the med I would have to do the research etc. My pdoc won't do it. Then there is the question ... as in I don't have any. So I wouldn't be able to pay for the medication anyway.
Blah!
Maxime
> > No, Tianepine isn't available in Canada. I want to try it.
> >
> > Maxime
> >
>
>
> What do you say, then? You speak French, don't you, and it's available there? Maybe we should take a nice vacation to Paris for an adequate trial period, say three months? ;-)
>
> Wouldn't that be nice?
>
> I know. That doesn't help. Pfinstegg was taking tianepine, though, so there is a way of using it in the US. Can you look up the mechanism for getting it in Canada, and then talk to your doctor?
>
> I've got an appointment in September to talk to a new psychopharmacologist, and will ask about it myself.
>
> Take care of my Canadian friend, won't you?
Posted by yxibow on August 12, 2006, at 1:59:39
In reply to Re: Reboxetine .... was it banned?, posted by SLS on August 3, 2006, at 14:32:23
> > Hi
> >
> > Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
> >
> > Does anyone know?
>
>
> To the best of my knowledge, reboxetine simply failed to produced successful clinical studies to submit to the FDA.
>
>
> - Scott
Cymbalta for some replaces the Reboxetine that never came, but yes, to the dismay of psychiatrists at the time as I remember it did not come to market in the US.
Posted by SLS on August 12, 2006, at 6:08:24
In reply to Re: Reboxetine .... was it banned? » SLS, posted by yxibow on August 12, 2006, at 1:59:39
> > > Someone told me that Reboxetine was banned in the U.S. I just thought it was never available.
> > >
> > > Does anyone know?> > To the best of my knowledge, reboxetine simply failed to produced successful clinical studies to submit to the FDA.
> Cymbalta for some replaces the Reboxetine that never came, but yes, to the dismay of psychiatrists at the time as I remember it did not come to market in the US.
The drug company was required by the FDA to produce clinical data originating in the US, as is common practice. Both of the clinical trials that were conducted failed. Neither reboxetine nor the comparator drug, fluoxetine, achieved response rates exceeding placebo. The company elected not to pursue approval beyond this point.
I am left with the impression that reboxetine does not have as high a success rate as most other antidepressants.
Ed_UK: What are you seeing as a trend in the prescribing frequency of reboxetine?
- Scott
Posted by ed_uk on August 12, 2006, at 10:17:24
In reply to Re: Reboxetine .... was it banned? - Ed_UK ?, posted by SLS on August 12, 2006, at 6:08:24
Hi Scott
>What are you seeing as a trend in the prescribing frequency of reboxetine?
It's rarely used. It never really 'caught on' in the UK.
Ed
This is the end of the thread.
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