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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by kylenn on August 3, 2006, at 3:48:28
I am by far no expert on ecstasy (sp?)
But I am pretty sure I read somewhere that it works similarly to ssris in that it hits the serotonin reuptake inhibitors in the brain and allows for collosal amounts of serotonin to be available, way more than a prescribed ssri.
I have never taken ecstasy, and I never will. I have heard (again, source unclear) that afterwards, you have a sort of crash as your brain has been completely drained of serotonin.
That sometimes, the receptors get burned out and never completely rebound, and then you have a depression that is unresponsive to ssri's and other anti-depressants, leaving you in depression purgatory forever.
No thanks.
But I do think that if it acts on the same neurotransmitter as the ssri's, then it would have similar side effects (like yawning)
By the way, I did reduce my dose of Wellbutrin from 600 to 300, and the yawning has diminished significantly. I agree with the earlier post that it is the synergy of the lexapro and wellbutrin--a kind of 2 + 2 = 5 situation.
Posted by MoparFan91 on August 3, 2006, at 11:25:57
In reply to ecstasy and ssris, posted by kylenn on August 3, 2006, at 3:48:28
Posted by noelle on August 4, 2006, at 15:57:47
In reply to Couldn't you take Tryp/5-HTP to fix the depletion? (nm) » kylenn, posted by MoparFan91 on August 3, 2006, at 11:25:57
I never had depression even close to the degree that I have now untill I started doing exstasy. AFter that I never reacted to anything the same not even coffee. I am completely resistant to ssri's and can't take benzo's energy drink stimulants without becoming severely depressed. Its hell and I would trade anything to go back and tell myself not to do it
Posted by linkadge on August 6, 2006, at 6:28:03
In reply to Re: Couldn't you take Tryp/5-HTP to fix the depletion?, posted by noelle on August 4, 2006, at 15:57:47
Please read this whole post before you freak out.
Ecstacy is not the same as SSRI's. Reuptake of serotonin is only one of the actions of ecstacy.
Ecstacy causes a massive release in serotonin and dopamine in addition to effects on serotonin reuptake, and monoamine oxidase inhibition.
The neurotoxic effects of ecstacy are likely unrelated to its effects on serotonin uptake, and more a result of the serotonin release.
Yes neurotoxicity to the serotonergic system is rough, but *not* the end of the world.
Serotoninergic neurons can be replaced, but it takes time. The growth factor BDNF when elevated, can troph the serotonergic system.
Tryptophan or 5-htp may help some of the symtpoms, but if there has been actuall dammage to the serotonergic system, this will not fix it.
It could provide symptomatic improvement untill such a time as the serotoniergic system has had a chance to heal. This could take years, decades, who knows, it depends on the extent of the problem.Never take ecstacy again.
Supplements I would recomend you experiement with are tryptophan, or (5-htp), Niacine, b6, folic acid, Omega-3, SJW, vigourous aerobic exercise (the best way to induce BDNF expression). Certain minerals like chromium, selenium, and magnesium may help too.
**It is not a hopeless situation**, that is, if you never touch the drug again.
Take care, and email me at linkadge@hotmail.com if you need any more help. I've been helping a friend get better from heavy ecstacy use, and he is doing better. He says that he is feeling more stable than he has in a long time since doing the drug.
Take care.
Linkadge
Posted by SLS on August 6, 2006, at 7:03:43
In reply to Re: Couldn't you take Tryp/5-HTP to fix the depletion?, posted by linkadge on August 6, 2006, at 6:28:03
> Supplements I would recomend you experiement with are tryptophan, or (5-htp), Niacine, b6, folic acid, Omega-3, SJW, vigourous aerobic exercise (the best way to induce BDNF expression). Certain minerals like chromium, selenium, and magnesium may help too.
You might want to look into inositol too. Myo-inositol seems to be a marker of tissue repair and accumulates around glial cells in former MDMA users. I don't know to what degree increasing inositol intake would promote this process, though. Even if it doesn't really help with this, it is a good supplement to keep serotonin receptors and cell membranes healthy.
- Scott
Posted by kylenn on August 6, 2006, at 11:27:04
In reply to Re: Couldn't you take Tryp/5-HTP to fix the deplet, posted by SLS on August 6, 2006, at 7:03:43
Thanks, Scott
This is the end of the thread.
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