![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 20 to 44 of 44. Go back in thread:
Posted by MrBrice on June 19, 2006, at 14:21:06
In reply to Dogmatil » MrBrice, posted by Declan on June 19, 2006, at 1:13:57
> Who thought that one up? Is that amisulpride (Solian here)? What's Dosulpin?
> You should see me at parties trying to start up a conversation about projective identification or foreign policy until the vodka gets the better of me. Never learned that chit chat can be fun in such circumstances (at other times it can be OK).
> But what makes us feel comfortable? It's a mystery to me. So Dogmatil can help with that?
> Declan
Hey declan,
I can imagine you trying to get the converstation, but the conversation doestn't really go all that smoothly does it? :-) actually its not so funny but we have the see the funny side of it i guess.Yes, dogmatil helps for this, so does dosulpin.
Here's what my doc did:
The dosulpin has to be taken round 8pm, it makes you sleep well and after 2-3 months (pretty long) its also a good antidepressant.
The dogmatil is taken in the morning (first 100mg, then 50mg) and it is not amisulpride, but sulpiride. It makes you indeed more alert, and thus you can get into a situation and have some conversation.
The third medication is xanax, just for the anxiety if you might have it.The three meds are a real good combination, they are not dangerous at all, and indeed, they get you back on track and talking to people, making friends again ;)
My doc is pretty old and told me this: Lots of people don't respond to many of the meds i give them, but when i then go for sulpiride and prothiaden (dosulpin), they are on their way.
Might give it a shot ;)
grtz,
Brice
Posted by MrBrice on June 19, 2006, at 14:26:15
In reply to Re: Social Anxiety and nothing to say., posted by FrequentFryer on June 19, 2006, at 10:32:13
> Heh I didnt think I would get any responses to this post.. But yeah you guys know EXACTLY what were all going through. (makes me slightly Anti Depressed :)
> Its crazy, I dont even want to admit the amount of time Ive spent laying in bed staring at the wall procrastinating about stupid sh*t, atleast in bed your comfortable thats how I see it. And yeah I think it is mostly Dopamine related.
> But yeah anyways on to the meds.
> All the Drugs Ive taken legal or not seem to just poop out. (Sure SSRI's and MAOI's last longer then Amphetamines) But the thing is I have this theory on Poop out now. Me personally in the 4 or 5 years Ive been taking Anti-D's I probably havn't been on 1 Anti depressant for more then 2 months, I have been constantly changing, and I always go straight to the maximum dose within a couple of days. I think this can cause Poop to a degree. Theoretically you shouldn't be able to get tollerance to an anti-D but I dont think that is the case.
> Anyways I think Ive come up with a solution (maybe). CYCLE YOUR MEDS! Im gonna continue my drug holiday & stay cleen for atleast a month to try and get my body and brian back to base line, then try some diffrent meds or atleast meds I havnt had in a long time {ALLOT OF WHICH YOU PEOPLE HAVE JUST POSTED ABOUT}
> Im thinking Abilify might be worth a shot, maybe Buprenorphine or another opiate, stimulants are great for a short while. Hopefully after all this my body will have forgotten how to tollerate Anti-D's and Ill stick to effexor then slowly ween myself of it & then HOPEFULLY by that time I will have such a kick *ss life my brain will be switched onto happiness be default.
Hey frequentfryer,please don't go for the opiates man.
I think I know what you're feeling and its not so fun, but opiates might actually f** you up for the rest of your life.
Try maybe what i recommendet to declan: Sulpiride, dosulpin (prothiaden) and maybe some xanax. I bet it might help you very well ;)
You say the bed is the only place you feel comfortable...I know what you're saying, it's just something called anxiousness, it's very well treatable, try to get a benzo and you'll feel comfortable again around people too ;)but don't go for the opiates mate, please don't.
grtz,
Brice
Posted by Declan on June 19, 2006, at 17:20:58
In reply to Re: Dogmatil Declan, posted by MrBrice on June 19, 2006, at 14:21:06
How do you find sulpiride and dosulpin (with which I'm not familiar) sexwise? I've heard people say here that amisulpride (in small doses) was bad that way.
Declan
Posted by Bonnie_CA on June 19, 2006, at 20:23:31
In reply to Social Anxiety and nothing to say., posted by FrequentFryer on June 18, 2006, at 5:40:47
> Sure Im extremely paranoid as to what people think about me, but I think my main problem is I litterally can't think of anything half decent to talk about with anyone.
> I guess I need more hobbies or something but its so hard because Im really not interested and can't be bothered doing anything.
>
> AAARRRRHH.... Sorry I stopped talking my meds and don't feel much worse but... I dunno....
> Just felt like babbling.
I like reading this, because this just confirms to me the difference between GAD and SAD. I have GAD, and I never have trouble finding something to say. I have more of a problem finding out when to shut up! LOL In fact, the more nervous I get, the more I talk. *sigh* I almost wish it was a social anxiety problem than generalized. Then I wouldn't look like such a moron LOL.-Bonnie
Posted by SFY on June 19, 2006, at 21:40:53
In reply to Re: Social Anxiety and nothing to say. » SFY, posted by shasling on June 19, 2006, at 12:35:49
> I am aware of the same distinction, and it is b&w - its a totally different animal. Its downright freaky how the brain can just stop firing. Ever see that movie Awakenings? - its like that, albeit nowhere near as severe. But its hard not to identify with the condition they presented, in a small way.
>
> Anyway, sorry to hear about the Requip, I was kinda having hopes for that. FWIW, selegeline never did a thing for me with respect to this problem. I hope Emsam serves you better...
>
> SuzieDon't let my experience with Requip stop you from trying it - others have found it helpful. It may be that there are different causes for our dopamine-related issues (mine are SA, anhedonia, amotivation, & dysthymia) that require different treatments.
Low dose selegiline (with phenylalanine supplements) did nothing for me either. As I had a good response to Nardil (but eventually leading to intractable insomnia), I'm hoping that the higher dose provided by Emsam might have a more positive effect.
Good luck!
Posted by FrequentFryer on June 19, 2006, at 22:05:30
In reply to Re: Social Anxiety and nothing to say. ferquentfry, posted by MrBrice on June 19, 2006, at 14:26:15
Ok thanks Brice. I wont go for the Opiates.
I have tried Amisulpride before and it didn't do anything. Sulpride isn't much different from Amisulpride is it?
Also do TCA's work better then SSRI's for some?
Ive never given a TCA a fair trial because of side effects.
Posted by Bonnie_CA on June 20, 2006, at 1:51:26
In reply to Re: Social Anxiety and nothing to say., posted by Bonnie_CA on June 19, 2006, at 20:23:31
You know, after thinking about it harder, while I have no problem talking in person, I am terrified on the phone with strangers. I don't know why. Doesn't exactly classify me as SAD, but in that respect, I can understand not being able to articulate thoughts due to anxiety. I get anxious and I'm afraid I'll say something stupid. But it's only the phone. Hmm.
Like every other person has posted before, it's your anxiety causing you to clam up, and it's not your fault. I'm sure the right med will straighten that out, and perhaps some CBT.
-Bonnie
>
>
> I like reading this, because this just confirms to me the difference between GAD and SAD. I have GAD, and I never have trouble finding something to say. I have more of a problem finding out when to shut up! LOL In fact, the more nervous I get, the more I talk. *sigh* I almost wish it was a social anxiety problem than generalized. Then I wouldn't look like such a moron LOL.
>
> -Bonnie
>
Posted by mike lynch on June 20, 2006, at 3:18:26
In reply to Re: Social Anxiety and nothing to say., posted by Bonnie_CA on June 20, 2006, at 1:51:26
Could the meds be causing the problem of ones personality being "dull"?? There's so many different possibilities, it could be the result of the anxiety not allowing you to share anything you would want to contribute, or it could be as easy as just not having anything to say, and the anxiety not being an issue. What is unfortunate for me is that, I would benefit off meds that allow me to articulate my thoughts to people, without refraining to do so for whatever reason, but when I go on the meds, some parts of my personality seem drained, so even when I'm willing to do things that I usually wouldn't socially.. the meds just dullen my personality. Maybe the reason for the dullnes is the meds, you'd probably be pretty clear on that though
Posted by Tom Twilight on June 20, 2006, at 9:50:44
In reply to Re: Social Anxiety and nothing to say., posted by mike lynch on June 20, 2006, at 3:18:26
Just wanted to say that I'm not advocating the use of Opiates to treat Social Anxiety!
Its one of those cases where the cure is far worse than the disease!
Posted by MrBrice on June 20, 2006, at 13:09:36
In reply to Re: Dogmatil Declan » MrBrice, posted by Declan on June 19, 2006, at 17:20:58
> How do you find sulpiride and dosulpin (with which I'm not familiar) sexwise? I've heard people say here that amisulpride (in small doses) was bad that way.
> Declan
no problem what so ever ;)
Posted by MrBrice on June 20, 2006, at 13:13:56
In reply to Re: Social Anxiety and nothing to say. ferquentfry » MrBrice, posted by FrequentFryer on June 19, 2006, at 22:05:30
> Ok thanks Brice. I wont go for the Opiates.
> I have tried Amisulpride before and it didn't do anything. Sulpride isn't much different from Amisulpride is it?
> Also do TCA's work better then SSRI's for some?
> Ive never given a TCA a fair trial because of side effects.i dunno, but sulpiride is different from the amisulpride tough...you're supposed to take sulpiride in small doses (in higher doses it has no good effects) and it really helps for me. Makes me more rational and indeed, more talkative.
The tricycle dosulpin is a very 'clean' drug, it is very user friendly. It only works after 2-3 moths tough, then it really is a very good antidepressant. I've tried prozac and efexor before with no effects what so ever, and this one really works... might give it a go.
all the best,
Brice
Posted by ed_uk on June 20, 2006, at 16:03:06
In reply to Re: Dogmatil Declan » MrBrice, posted by Declan on June 19, 2006, at 17:20:58
Hi Dec
Dothiepin, also known as dosulepin, is a tricyclic antidepressant. It is available in the UK and Australia but not the US. Dothiepin has been around a long time - it is available as an inexpensive generic. It is also available under several different brand names such as Prothiaden and Dothep (in Australia). Prothiaden was the original brand.
Years ago, dothiepin was the most widely prescribed antidepressant in England. In recent years, doctors have been advised to exercise caution in prescribing dothiepin because it is very dangerous in overdose - people have often used it to kill themselves.
You may be discouraged to hear that dothiepin is closely related to amitriptyline.
Eddy
Posted by theo on June 20, 2006, at 17:15:31
In reply to Re: Social Anxiety and nothing to say. » FrequentFryer, posted by shasling on June 18, 2006, at 5:52:30
When do you take the Abilify, morning or evening?
Posted by shasling on June 20, 2006, at 17:49:23
In reply to Re: Social Anxiety and nothing to say. » shasling, posted by theo on June 20, 2006, at 17:15:31
> When do you take the Abilify, morning or evening?
I take 5 mg about 6 a.m., and 5 mg at 2 p.m... Really skittish about taking too much at one time, I once had a very bad reaction to it which I think was dose-dependent.
Suzie
Posted by Declan on June 21, 2006, at 8:03:56
In reply to Prothiaden » Declan, posted by ed_uk on June 20, 2006, at 16:03:06
Hi Ed
A friend said Prothiaden was his favourite AD. The one he hated most was moclobemide. Not what I wanted to hear.
Declan
Posted by ed_uk on June 21, 2006, at 13:48:38
In reply to Re: Prothiaden » ed_uk, posted by Declan on June 21, 2006, at 8:03:56
Hi Dec
I have a friend (who is the same age as you - not that that's important). He has taken Prothiaden for a few years and finds it helpful with no side effects.
I once took Prothiaden myself. It pretty much knocked me out.
Ed
Posted by MrBrice on June 22, 2006, at 5:59:14
In reply to Re: Prothiaden » Declan, posted by ed_uk on June 21, 2006, at 13:48:38
> Hi Dec
>
> I have a friend (who is the same age as you - not that that's important). He has taken Prothiaden for a few years and finds it helpful with no side effects.
>
> I once took Prothiaden myself. It pretty much knocked me out.
>
> Edthat's normal, the first time you take it your down for a day...
like all other ad's its meant to be taken regularely.
grtz
Posted by ed_uk on June 22, 2006, at 14:39:48
In reply to Re: Prothiaden, posted by MrBrice on June 22, 2006, at 5:59:14
Hi Brice,
>that's normal, the first time you take it your down for a day...
I was down for more than a day, I was down the whole time I was taking it!
Ed
Posted by hgi698 on June 22, 2006, at 16:28:41
In reply to Re: Prothiaden, posted by ed_uk on June 22, 2006, at 14:39:48
Not having anything to say is a symptom of negative schizophrenia. I think it's referred to as alogia. How quickly you can talk is known as verbal fluency. It seems to be related to a deficit of functioning in the prefrontal cortex of the d1 receptors. If you have other negative symptoms like emotional blunting, apathy, attention deficit all these symptoms are related. Glycine 30 grams to 60 grams a day has been shown to allievate these symptoms. It's an amino acid and is fairly safe. You can order it fairly cheaply at iherb.com. I don't know if you have any of those other symptoms, but I do. I have a real problem with thinking about anything to say to people. I tried glycine and it made me feel worse, but it could work for you. I am not schizophrenic. Right now i take adderall, mirtazapine and buspirone all increase dopamine in the prefrontal cortex and seem to help somewhat. I am still not able to hold much of a conversation with anyone though so this isn't a success story.
Posted by hgi698 on June 22, 2006, at 16:40:08
In reply to Re: Social Anxiety and nothing to say., posted by FrequentFryer on June 19, 2006, at 10:37:23
By the way, i tried requip it made my verbal fluency much worse. When i was on it my capacity to talk about anything was drastically reduced. I think this is because it is an agonist at d2 autoreceptors leading to a decrease in dopamine synthesis and release. This leads to suboptimal stimulation of d1 receptors. Also ssri's would probably make your situation worse since they decrease dopamine in the prefrontal cortex (except fluoxetine).
Posted by zeugma on June 22, 2006, at 18:29:37
In reply to Glycine, posted by hgi698 on June 22, 2006, at 16:28:41
these two posts by hgi698 offer some interesting insights...
My verbal fluency is almost nil (people regularly comment that i am the slowest speaker they have ever heard). I'm not worried about that, as there are more important things in life than rate of words per minute.I might try glycine. Sarcosine, a glycine reuptake inhibitor, has shown some efficacy in dealing with negative symptoms.
-z
Posted by MrBrice on June 23, 2006, at 3:23:54
In reply to Re: Prothiaden, posted by ed_uk on June 22, 2006, at 14:39:48
> Hi Brice,
>
> >that's normal, the first time you take it your down for a day...
>
> I was down for more than a day, I was down the whole time I was taking it!
>
> Ed
>
>hmm, normally it fades...
Well, the human body works in mysterious ways ;)grtz
Posted by ed_uk on June 23, 2006, at 14:11:15
In reply to Re: Prothiaden, posted by MrBrice on June 23, 2006, at 3:23:54
Hi MrB,
What does grtz mean?
Ed
Posted by MrBrice on June 23, 2006, at 17:43:09
In reply to Re: Prothiaden » MrBrice, posted by ed_uk on June 23, 2006, at 14:11:15
> Hi MrB,
>
> What does grtz mean?
>
> Edit's young people slang :-)
it means greets :) heheanother thing ed, i think it was u who asked me to inform you about akton right, well my doc just prescribed it, i'm gonna try it tomorrow. I'll keep you informed.
grtzz :-)
Brice
Posted by Muting on August 18, 2007, at 12:20:14
In reply to Re: Prothiaden, posted by MrBrice on June 23, 2006, at 17:43:09
I know well the feeling, sitting there, with your mind in blank, people making jokes and saying things that you cant quite grasp the meaning, absent, vacant, retractive, wondering whats wrong with you, so worried, you think you need a girlfriend, you think you need a stronger dose of med, you think youre just very different, like those extravagant artists. But basically you feel like a dull stranger, after the party you can come home and cry at bed and guess thats impossible to get to that girl you like, you are not ambitious, you dont want to be the funny guy, or the awsome orator or story teller, you just want to be cool, to be able to deal with affection, to feel natural around others.
Im on wellbutrin 300 mg, zyprexa 2.5 mg, clonazepam 2 mg.
i think im going to try with 4 mg clonazepam, i dont know if the zyprexa is too low, i take some coffee to get stimulated, but nothing works.
greetings and luck and hope for others in pain.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.