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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by ed_uk on May 6, 2006, at 11:16:40
Sinequan, Pfizer's tricyclic AD, will soon be dicontinued in the UK. I do not know whether it will remain available in the US.
Ed
Posted by ed_uk on May 6, 2006, at 11:19:57
In reply to Sinequan to be discontinued in the UK, posted by ed_uk on May 6, 2006, at 11:16:40
Generic doxepin (Sinequan) is not available in the UK. As a result, when the Sinequan brand is discontinued, doxepin will not be available in the UK at all.
Is doxepin available as a generic in the US?
Ed
Posted by tygereyes on May 6, 2006, at 11:47:54
In reply to Re: Sinequan to be discontinued in the UK » ed_uk, posted by ed_uk on May 6, 2006, at 11:19:57
I don't know - I do know that my psychiatrist never brought it up as a possibility for me when we were trying TCAs, which (if it is available) would be odd because I was adamant about not gaining weight on a TCA.
Posted by zeugma on May 6, 2006, at 13:14:26
In reply to Re: Sinequan to be discontinued in the UK, posted by tygereyes on May 6, 2006, at 11:47:54
> I don't know - I do know that my psychiatrist never brought it up as a possibility for me when we were trying TCAs, which (if it is available) would be odd because I was adamant about not gaining weight on a TCA.>
That is not odd at all, doxepin is perhaps the most apt to produce weight gain of all the TCA's.
Doxepin is available as a generic in the U.S., but I don't think it's used as an AD often, it is more of a sedative/anxiolytic.
-z
Posted by tygereyes on May 6, 2006, at 15:22:42
In reply to Re: Sinequan to be discontinued in the UK » tygereyes, posted by zeugma on May 6, 2006, at 13:14:26
> > I don't know - I do know that my psychiatrist never brought it up as a possibility for me when we were trying TCAs, which (if it is available) would be odd because I was adamant about not gaining weight on a TCA.>
>
> That is not odd at all, doxepin is perhaps the most apt to produce weight gain of all the TCA's.
>
> Doxepin is available as a generic in the U.S., but I don't think it's used as an AD often, it is more of a sedative/anxiolytic.
>
> -z
>
>Ah, you are correct.
My cognition seems to be impaired lately (hello Parnate withdrawal, much?)
Which TCA am I thinking of that has less propensity to cause weight gain than Desipramine? There was a head-to-head comparison with Desipramine and another drug; I believe the study was done in the 1980's. It's been a while since I read it.
Posted by fairywings on May 6, 2006, at 15:32:51
In reply to Sinequan to be discontinued in the UK, posted by ed_uk on May 6, 2006, at 11:16:40
Why's it being discontinued? Was it a safety thing? I'm curious because I'm sure this is one of the meds I was on when I was a teenager -both sinequan and doxepin sound very familiar.
fw
Posted by Phillipa on May 6, 2006, at 16:01:47
In reply to Re: Sinequan to be discontinued in the UK » ed_uk, posted by fairywings on May 6, 2006, at 15:32:51
Yes how come? Love Phillipa
Posted by ed_uk on May 6, 2006, at 16:18:51
In reply to Re: Sinequan to be discontinued in the UK » ed_uk, posted by fairywings on May 6, 2006, at 15:32:51
Pfizer claim it's a manufacturing problem. I really don't know what's going on with Pfizer lately, they seems to have had manufacturing problems with most of their products.
ed
Posted by tygereyes on May 6, 2006, at 17:03:38
In reply to Re: Sinequan to be discontinued in the UK » fairywings, posted by ed_uk on May 6, 2006, at 16:18:51
> Pfizer claim it's a manufacturing problem. I really don't know what's going on with Pfizer lately, they seems to have had manufacturing problems with most of their products.
>
> edPfizer's whole company is a Manufacturing Problem.
Posted by yxibow on May 7, 2006, at 0:25:34
In reply to Re: Sinequan to be discontinued in the UK » ed_uk, posted by ed_uk on May 6, 2006, at 11:19:57
> Generic doxepin (Sinequan) is not available in the UK. As a result, when the Sinequan brand is discontinued, doxepin will not be available in the UK at all.
>
> Is doxepin available as a generic in the US?
>
> EdYes, and my experience with it as a replacement for Trazodone induced priapism. I never really regained a halfway decent conscious state for nearly 18 hours over a weekend. That was the end of my experiment with doxepin and back to the Trazodone despite the problems.
Some people though after they work through that (highly suggest a weekend) may take doxepin for insomnia and not be passed out for 2 days. It also happens to be a very strong and effective H1 and H2 blockade and is good for people who have complex angioedemic allergy problems (like my mother.)
This is the end of the thread.
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