Psycho-Babble Medication Thread 630544

Shown: posts 1 to 7 of 7. This is the beginning of the thread.

 

how do you *increase* cingulate cortex activity?

Posted by iforgotmypassword on April 8, 2006, at 11:04:09

i was wondering what drugs may actually increase cingulate cortex activity or of the included relevant parts. it seems to be implicated in complusive hoarding, a serious problem of mine. heres a link... it has a 'neurobiology' section:

http://ocfoundation.org/1005/m110a_003.htm

it also seems that this may be a region that really hurts peoples ability to express emotion, articulate, assess situations and perform tasks. it seems that overactivity is linked to depression, but it seems like it may be an oversimplification, thus the numbing effects of SSRIs. it is may be what makes you feel the depression as opposed to the all to common and ignored scenario of knowing that you are depressed, but are simply too numb to feel or express anything.

 

Re: how do you *increase* cingulate cortex activit

Posted by SLS on April 8, 2006, at 11:35:15

In reply to how do you *increase* cingulate cortex activity?, posted by iforgotmypassword on April 8, 2006, at 11:04:09

Sounds like a question Linkadge could answer for you.


- Scott

 

Re: how do you *increase* cingulate cortex activit

Posted by Caedmon on April 8, 2006, at 11:40:28

In reply to Re: how do you *increase* cingulate cortex activit, posted by SLS on April 8, 2006, at 11:35:15

Take my response with a grain of salt, but... Probably dopaminergics? That's my guess anyway. Cingulate overactivity being related to OCD symptoms, you want to *avoid* SSRIs or similar meds, and look at stuff that hits dopamine.

Do you have symptoms of ADD?

- C

 

Re: how do you *increase* cingulate cortex activit » iforgotmypassword

Posted by SLS on April 8, 2006, at 12:01:37

In reply to how do you *increase* cingulate cortex activity?, posted by iforgotmypassword on April 8, 2006, at 11:04:09

> i was wondering what drugs may actually increase cingulate cortex activity or of the included relevant parts. it seems to be implicated in complusive hoarding, a serious problem of mine. heres a link... it has a 'neurobiology' section:
>
> http://ocfoundation.org/1005/m110a_003.htm
>
> it also seems that this may be a region that really hurts peoples ability to express emotion, articulate, assess situations and perform tasks. it seems that overactivity is linked to depression, but it seems like it may be an oversimplification, thus the numbing effects of SSRIs. it is may be what makes you feel the depression as opposed to the all to common and ignored scenario of knowing that you are depressed, but are simply too numb to feel or express anything.

This is outside of my area of interest, but the modulation of glutamate activity using NMDA receptor antagonists might be worth taking a look at. Memantine or amantadine. Maybe even ketamine.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16034443&query_hl=23&itool=pubmed_docsum

What is your theory for using such a treatment?


- Scott

 

Re: how do you *increase* cingulate cortex activit

Posted by iforgotmypassword on April 8, 2006, at 16:24:08

In reply to Re: how do you *increase* cingulate cortex activit » iforgotmypassword, posted by SLS on April 8, 2006, at 12:01:37

sorry, passed out again. hmm, interesting link. it's kind of scary that the even with the blood flow increases, the glutamate release starts causing problems. but that's ketamine, and could just be showing what an extreme of the nmda-antagonist idea could cause? jay a. goldstein did seem to focus a lot on how nmda receptor antagonism is helpful, and used lowered dose ketamine for results (this is for CFS, but also relates to his theories of cognitive salience which is very interesting). akwardly, i haven't heard much about amantadine though, other than marginal short term benefit, so i always worry if it is really a serious nmda receptor inhibitor, and doesn't just cause an initial reaction due to some level of dopamine release. i guess then there's memantine, but it's hard to get in canada unless you have alzheimer's apparently. do you know much about amantadine and it's activity?

my reasoning isn't very solid, except in the sense that hoarding is a huge problem i have in every aspect, so i figure maybe a lot of my problems are rooted in similar neurochemistry. (the symptoms underline endless indecision, churning thoughs through your mind, inability to do things and assess what changes mean and not resist, and just awkward behaviour that i epitomize) OCD not so much in my case (OCPD yes, though)... but apparently it seems to be a distinct symptom and neurological profile from OCD (which seems to be showing why SSRIs and clomipramine have little luck affecting hoarding) UCLA was doing a study on galantamine (Razadyne, formerly Reminyl), but i don't know what happened to it. :(

(sorry for the poor phrasing.)

 

Re: how do you *increase* cingulate cortex activit » iforgotmypassword

Posted by Phillipa on April 8, 2006, at 18:27:37

In reply to Re: how do you *increase* cingulate cortex activit, posted by iforgotmypassword on April 8, 2006, at 16:24:08

My husband seriously in number four. Love Phillipa

 

Re: how do you *increase* cingulate cortex activit » iforgotmypassword

Posted by River1924 on April 9, 2006, at 16:07:25

In reply to how do you *increase* cingulate cortex activity?, posted by iforgotmypassword on April 8, 2006, at 11:04:09

Although I don't have time to find the article, I was trying to figure out things about temporal lobe epilepsy and REM sleep and the anterior cingulate cortex...

I believe Wellbutrin SR increased activation of the ACC during REM sleep. If I understood the article, though, it only returned it to normal.

Sometimes I believe in the collective consciousness: I was just going to write a question just like yours...

I hope we find the answers. I hope your share what you find with this board and with me. Thanks. River.


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