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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by challenged on March 30, 2006, at 3:12:41
Hello,
I am now taking wellbutrin 300 mil and topamax 200 mil daily. I was just wondering if anyone out there is taking the two together and what you may know about the two together and any info for me will be appreciated.My pdoc was going to give me Geodon to take with the topamx and I refused the Geodon after reading about it on here. Any comments on Geodon and topamax together? Do you think I did the right thing?...Wellbutin is for my deep depression caused from repression and the topamx for a mood stabilizer as well as my horrific migranes.
I have learned so much fromm this board so please anyone with any information whether it be personal reactions or not will be a great help to me. Seems my pdoc has not yet hit it right for me. Not feeling too great yet and been on meds for the last 6 years....from prozac to lexapro etc.. gained weight and then lost that after stopping the fat pills and insisted on something else because my depression was worsened because of my personal image. Have not yet seen a weight loss from the two meds together. Anyone? And any information please.......Thanks much!
Nettie
Posted by JaclinHyde on April 1, 2006, at 15:28:12
In reply to topamax and wellbutrin XL, posted by challenged on March 30, 2006, at 3:12:41
Here is what I have learned about combining Wellbutrin and Geodon. I even checked Abilify and Wellbutrin with the same result.
"Patient Regimen
GEODON ORAL
WELLBUTRIN ORALInteractions
Moderate Interaction
BUPROPION/ANTIPSYCHOTICS
Wellbutrin Oral and Geodon Oral may interact based on the potential interaction between BUPROPION and ANTIPSYCHOTICS.Bupropion/Antipsychotics
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
MONOGRAPH TITLE: Bupropion/Antipsychotics
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Both bupropion and the antipsychotics are known to lower the seizure threshold.(1)
CLINICAL EFFECTS: Concurrent use of bupropion and an antipsychotic may result in additive effects on the seizure threshold, increasing the risk of seizures.(1)
PREDISPOSING FACTORS: The risk of seizures may be increased in patients with a history of head trauma or prior seizure; CNS tumor; severe hepatic cirrhosis; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; use of over-the-counter stimulants an anorectics; a total daily dose of bupropion greater than 450 mg or single doses greater than 150 mg; rapid escalation of bupropion dosage; diabetics treated with oral hypoglycemics or insulin; or with concomitant medications known to lower seizure threshold (antidepressants, theophylline, systemic steroids). (1)
PATIENT MANAGEMENT: The concurrent use of bupropion and antipsychotics should be undertaken only with extreme caution and with low initial bupropion dosing and small gradual dosage increases.(1)
DISCUSSION: Because of the risk of seizure from concurrent bupropion and other agents that lower seizure threshold, the manufacturer of bupropion states that the concurrent use of bupropion and antipsychotics should be undertaken only with extreme caution and with low initial bupropion dosing and small gradual dosage increases.(1)
REFERENCE:
1.Wellbutrin (bupropion hydrochloride) US prescribing information. GlaxoSmithKline January, 2005."
Hope this helps!
JH
This is the end of the thread.
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