![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Maxime on February 19, 2006, at 18:46:45
Hi. I am hoping Ed or SLS can answer this one. As you know, I lactate on anti-psychotics. But I also lactated on Desipramine. What is the purpose of having raised prolactin levels? I mean, what makes these meds raise prolactin levels?
Maxime - moo
Posted by Phillipa on February 19, 2006, at 20:33:45
In reply to Why would a tricyclic make lactate, posted by Maxime on February 19, 2006, at 18:46:45
Don't know. moo. Fondly, Phillipa
Posted by SLS on February 20, 2006, at 1:04:35
In reply to Why would a tricyclic make lactate, posted by Maxime on February 19, 2006, at 18:46:45
> Hi. I am hoping Ed or SLS can answer this one. As you know, I lactate on anti-psychotics. But I also lactated on Desipramine. What is the purpose of having raised prolactin levels? I mean, what makes these meds raise prolactin levels?
>
> Maxime - moo
I don't know.You might have something going on with your hypothalamus or pituitary gland. My off-the-cuff guess is that your GH response to NE is blunted, perhaps being replaced by an overexpression of insulin-like growth factor. This might trigger lactation.
Have you ever tried to use clonidine to prevent desipramine-induced lactation?
- Scott
Posted by fenix on February 20, 2006, at 7:00:01
In reply to Why would a tricyclic make lactate, posted by Maxime on February 19, 2006, at 18:46:45
> Hi. I am hoping Ed or SLS can answer this one. As you know, I lactate on anti-psychotics. But I also lactated on Desipramine. What is the purpose of having raised prolactin levels? I mean, what makes these meds raise prolactin levels?
>
> Maxime - mooIt is called hyperprolactinemia. I'm gonna try to not make this complicated, here goes: The anterior pituitary has lactotrophic cells which have dopaminergic receptors that are getting blocked by the psychotheraputic drugs you are taking.
So basically, dopamine regulates prolactin and psychotheraputic drugs affect dopamine. Your endocrine system ends up getting all annoyed and stuff and is like "stop disturbing me with your loud rock and roll music, you loud neighborly antagonists!"
Satisfied, I hope so! Anyway, there are some "not so nice stuff" concerned with hyperprolactinemia. I would not mind sharing this "stuff" with you. You have but to ask, however, it might take me a while to respond.
Posted by Maxime on February 20, 2006, at 11:14:27
In reply to Re: Why would a tricyclic make lactate, posted by SLS on February 20, 2006, at 1:04:35
No I have never used any med to prevent it. Ed said that Mirapex might help and that is next on the list to add to my cocktail. Clonidine wouldn't be a good idea since I have low blood pressure to begin with.
Thanks Scott!
Maxime
>
> I don't know.
>
> You might have something going on with your hypothalamus or pituitary gland. My off-the-cuff guess is that your GH response to NE is blunted, perhaps being replaced by an overexpression of insulin-like growth factor. This might trigger lactation.
>
> Have you ever tried to use clonidine to prevent desipramine-induced lactation?
>
>
> - Scott
Posted by Maxime on February 20, 2006, at 11:17:25
In reply to Re: Why would a tricyclic make lactate, posted by fenix on February 20, 2006, at 7:00:01
Thank you! That is an excellent explanation. And yes, I would like you to tell the not so good stuff about hyperprolactinemia. Respond when you can.
Maxime
> It is called hyperprolactinemia. I'm gonna try to not make this complicated, here goes: The anterior pituitary has lactotrophic cells which have dopaminergic receptors that are getting blocked by the psychotheraputic drugs you are taking.
>
> So basically, dopamine regulates prolactin and psychotheraputic drugs affect dopamine. Your endocrine system ends up getting all annoyed and stuff and is like "stop disturbing me with your loud rock and roll music, you loud neighborly antagonists!"
>
> Satisfied, I hope so! Anyway, there are some "not so nice stuff" concerned with hyperprolactinemia. I would not mind sharing this "stuff" with you. You have but to ask, however, it might take me a while to respond.
>
>
Posted by SLS on February 20, 2006, at 12:15:15
In reply to Re: Why would a tricyclic make lactate » SLS, posted by Maxime on February 20, 2006, at 11:14:27
> No I have never used any med to prevent it. Ed said that Mirapex might help and that is next on the list to add to my cocktail.
Oops. I was under the impression that you had already tried that. A similar drug that can be used for the hyperprolactinemia is cabergoline (Dostinex). It probably has a reduced potential for producing sedation and sleep-attacks. Chairman_MAO really likes this drug. I've never tried either one.
Good luck!
- Scott
Posted by fenix on February 20, 2006, at 13:03:16
In reply to Re: Why would a tricyclic make lactate » fenix, posted by Maxime on February 20, 2006, at 11:17:25
> Thank you! That is an excellent explanation. And yes, I would like you to tell the not so good stuff about hyperprolactinemia. Respond when you can.
>
> Maxime
>
>
> > It is called hyperprolactinemia. I'm gonna try to not make this complicated, here goes: The anterior pituitary has lactotrophic cells which have dopaminergic receptors that are getting blocked by the psychotheraputic drugs you are taking.
> >
> > So basically, dopamine regulates prolactin and psychotheraputic drugs affect dopamine. Your endocrine system ends up getting all annoyed and stuff and is like "stop disturbing me with your loud rock and roll music, you loud neighborly antagonists!"
> >
> > Satisfied, I hope so! Anyway, there are some "not so nice stuff" concerned with hyperprolactinemia. I would not mind sharing this "stuff" with you. You have but to ask, however, it might take me a while to respond.
> >
> >
>
>Hello again.
Actually this is a very in-depth article concerning hyperprolactinemia that you will find useful:
http://www.emedicine.com/med/topic1098.htm
This will just save a lot of time because you can read it at your leisure.
Also, basically the "bad stuff" I was talking about most likely doesn't concern you. I just want you to be aware that other things (some serious some not so serious) can cause the heightened prolactin you are having, but it is most likely the drugs you are on causing it, so you really have nothing to worry about.
Come to think of it, is your doctor aware of what is happening?
Posted by Maxime on February 20, 2006, at 13:38:38
In reply to Re: Why would a tricyclic make lactate, posted by fenix on February 20, 2006, at 13:03:16
Thanks I will read it.
Yes, my doctor knows. My endocrinologist also knows. I am suppose to have a blood test done to see what my prolactin level is. But I can't have been on any anti-psychotics for 4 weeks. I know that sometimes it can be caused by a tumour on the pituatary gland. I hope it's not that. I just tried an anti-psychotic so I will have to wait to have the blood test done.
Thanks again for all your info!
Maxime
> Hello again.
>
> Actually this is a very in-depth article concerning hyperprolactinemia that you will find useful:
>
> http://www.emedicine.com/med/topic1098.htm
>
> This will just save a lot of time because you can read it at your leisure.
>
> Also, basically the "bad stuff" I was talking about most likely doesn't concern you. I just want you to be aware that other things (some serious some not so serious) can cause the heightened prolactin you are having, but it is most likely the drugs you are on causing it, so you really have nothing to worry about.
>
> Come to think of it, is your doctor aware of what is happening?
>
>
>
>
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.