![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 12 to 36 of 36. Go back in thread:
Posted by willyee on February 8, 2006, at 15:55:23
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by linkadge on February 8, 2006, at 15:45:02
> I think the results of ensam as an antidepressant are very mixed. Most doctors believe that it is the MAO-A inhibition that carries the most theraputic benefit in depression.
>
> I think that a lot of patients who try it as an antidepressant find that it has a psychic energizing effect, but does not posess much of a mood brightening effect.
>
> It is also not too wise to use in cases of psychotic depression. It increases the activity of phenlythylamine which is a very strong endogenious amphetamine. Boosting phenyethylamine can produce stereotypical behavior associated with other stimulants.
>
>
>
> Linkadge
>
>But lets be fair and say your basising this from the people used in the study,not your average joe.
How many studies have outcomes totaly different?
As for either the tab or oral solution,i think we discussed to death how that cant be compared to the patch,dosage,introdcution to the body etc
Posted by LizinManhattan on February 8, 2006, at 18:31:46
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by RobertDavid on February 7, 2006, at 23:15:49
Oh yes, I would definitely wait for the patch! I just wanted to check and see if people had had any luck with taking selegiline orally since my doc didn't seem to think it's an effective a.d.
It would be so great to be able to take and MAOI (both Nardil and Parnate were great for my depression) but not have to deal with BP issues. Although from what I understand the FDA is arguing with Emsam's people about tyramine labeling right now...
Liz
> If I was going to try selegiline, I'd wait for the patch EMSAM. The FDA will most likely approve it by Feb 26th, then it will take a few months before it's available.
>
> My doctor who is envolved with writing the perscribing info for the drug co. tells me that it will definately be a good option for both anxiety and depression. I'm not really clear why, but he indicates that it will be far superior to the oral in terms of effectiveness, not to mention fewer side effects including weight gain, decreased libido as well as less food restrictions at the 20mg dose.
>
> I'm going to give it a try for SP with mild depression. My doc tells me that EMSAM may replace the klonopin I take now for SP or perhaps be a good blend with it. Should be interesting.....
Posted by LizinManhattan on February 8, 2006, at 18:33:40
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » RobertDavid, posted by River1924 on February 8, 2006, at 1:14:52
I'm sorry you haven't found relief. It took me 10 years to find something that worked. I wish you luck.
Liz> Don't get too excited. I have an liquid oral form and if I take more than a couple milligrams a week, I am wired and irritable. I suppose it is the fact that I have tried so many drugs but I don't believe in miracles anymore. Good luck though... everyone reacts to meds differently. Gotta keep trying and maybe, just maybe it will help you.
Posted by LizinManhattan on February 8, 2006, at 18:48:34
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 9:04:53
I used to think that my doctor wasn't like most psychiatrists. In other words, he would listen to me and wouldn't be afraid if I knew something he didn't. For example, when I told him about the reformulated Nardil and about Emsam he was very interested and said he hadn't heard about that yet. Most psychiatrists I have been in contact with (my brother's been through 22!) need to have their egos stroked and be worshipped as all-knowing, but mine hasn't shown any signs of that. I wonder... It would make me very sad if he did indeed blow me off about Selegiline. Maybe that's just what he was taught in med school? You're right though; how could he possibly have used it enough to know that it's not effective?
I'm not nuts about leaving the MAOI world and going on Remeron which supposedly causes weight gain in 25% of users so maybe I'll try the patch when it finally comes out. I'm pretty sure my doc would prescribe it if I made my case.
As for the Manhattan part of my name, I signed up with that name out of pure habit as that is what I always sign up as on message boards. I live in Manhattan, right next to the off-ramp for the 59th Street bridge until a few months ago. Now I'm 25 miles north of Manhattan. 34th Street does have some good shopping, although it's a tad too crowded for me!
Liz
> OMG i just wrote a long response to this and lost it,and it was good,uggh.
>
> Well hopefully it will reappear,but what i said in a nit shell was i dont see how ur doc was able to tell u deprenyl is not a good anti depressant.
>
> To date its only use here is for parkinson,it is extremly rare to see it used in the psych field as a off label anti depressant.
>
> Moais period are rare to find being used,so to say deprnyl,a maoi,one in which has almost zero documented history for depression in tab form used by a p-doc,over parnate/nardil,when its rare a maoi would even have been considered in the first place,its like four leaf clover.
>
> Your doc went one step further and said most people dont have luck with it for depression,so with the statement above id love to know where hes getting this theory from.For him to say that would mean not only has he encountered deprenyl for the use of depression a EXTREMLY EXTREMLY rare thing once,but rather munerous times,enough to come to a conclusion that it isnt helpful.
>
> Think about that,and as for the patch,lots of money,lots of time and work are being invested in this drug,people are putting up lots on it.More importantly lol it isnt OUT yet,so he could not have been referring to that because the drug is still unavailable.
>
> Personly,and dr bob just my own opinion lol,is when a doc is approached about something from a patient that they are not too familiar on,they seem to like to blow it off change the direction very very fast.
>
>
> I again in my own opinion have to say ur doc was blowing u off on the deprenyl cause he might not have been informed,so rather have u know something he doesent,he quickly moved away,.....i cant logicaly in anyway see how ur doc could be in a postion to have made a statement about deprenyl when it isnt even out yet,we are all waiting,the only info about deprenyl and depression mainly are from deep rooted net news groups,boards,foroums,and these are with deprenyl in no set dose etc,maois are not a popular choice in the psych world,and deprenyl a maoi would have to date been usd off label which is like finding a four leaf clover on the floor after tripping over a found wallet with tons of money,prior to this patch deprenyl info,history on depression is rare to none,ur doc seemed to make a very bold statement,i would personaly not credit it,instead id personaly look into emsam urself on the net and see how it works,look at some trial data,and see if u believe it might help.
>
> I luckly found a doc finaly who doesent care if i might know more than her on a certain drug,and she said this patch is unknown with many p-docs,it hasent hit there seminars yet,but she took the name from me and said thanks,and said she was gonna look it up at home that night,and let me know the second she has it come up in her little pysch world.
>
> P.s i miss manhattern,shopping on 34th lol,are u from there?
>
>
Posted by LizinManhattan on February 8, 2006, at 18:52:33
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » LizinManhattan, posted by Larry Hoover on February 8, 2006, at 10:15:42
Hi Lar,
Thanks so much for the information. What you say makes a lot of sense. A bit disappointing to hear that there might still be blood pressure issues though. AS long as it doesn't spontaneously cause hypertensive crisis (as Parnate did for me) I suppose I could deal with it!
Liz> Your psychiatrist is basing his opinion on oral selegiline, which really could be thought of as being a different drug. Selegiline is readily changed by digestive enzymes in the intestinal wall and the liver. This protective net of enzymes is called the first pass metabolism; all oral drugs pass through this gauntlet.
>
> If I recall correctly, as much as 60% of oral selegiline can be metabolized before it even gets into general blood circulation. And, the metabolites have activities that are different than the parent drug.
>
> In contrast, the patch delivery system allows selegiline to trickle through directly into general circulation, avoiding that significant destruction via first pass enzymes. You get different drug effects, because the selegiline pretty much makes it into the brain unchanged.
>
> It remains to be seen that Emsam is similar in effect to other MAOIs. And, individual differences in sensitivity to tyramine makes it hard to predict if food restrictions will apply or not. Some people may still have to watch their diet closely, to avoid BP effects.
>
> Lar
>
Posted by willyee on February 8, 2006, at 19:35:19
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » willyee, posted by LizinManhattan on February 8, 2006, at 18:48:34
Cool,im orginaly from redhook.....the old old REDHOOK where you knew your boundaries at night.
LOL i remeber i literaly was the only white face in the entire redhook,but i wouldent have changed it for the world,bad place,but grew up with great great people.
I hear redhook is changing into a very hih class place now anyway im not sure if u said ur going on remeron,all these postins criss crossins i might be confused,BUT just my opintion and i hate to scare you,disapoint you are anything,im just honestly sorry to hear ur choosing remeron,regardless i wish u luck and hope.
Posted by Phillipa on February 8, 2006, at 20:55:32
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 19:35:19
This us offtopic but not altogether so. They use the same delivery system for menopausal symtoms either a cream absorbed into the skin or a patch. Supposed to eliminate a lot of the side effects. The cream did that for me. Just a note that delivery systems do work differnely. Fondly, Phillipa
Posted by gibber on February 8, 2006, at 23:13:36
In reply to Selegiline/Deprenyl effective anti-depressant?, posted by LizinManhattan on February 7, 2006, at 21:35:15
one of the only emsam studies I know of. I had an appointment with Dr. Bodkin the study doctor a few months ago and he did recommend the patch to me. He was an amazing person to talk to and no ego. Unfortunately the doctor I have now is the complete opposite but he may give me the emsam when it comes out. Below is the study, the full article is free too:
Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients.
Bodkin JA, Amsterdam JD.
McLean Hospital, 115 Mill St. Belmont, MA 02478, USA. abodkin@mclean.harvard,edu
OBJECTIVE: The authors investigated the efficacy and safety of transdermal selegiline in adult outpatients with major depressive disorder. METHOD: Following a 1-week placebo lead-in, 177 adult outpatients with major depressive disorder were randomly assigned to receive transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) (N=89) or placebo (N=88) for 6 weeks. The patients followed a tyramine-restricted diet during the medication trial and for 2 weeks after completion of treatment. Response to medication or placebo was measured by using the 17-item and 28-item versions of the Hamilton Depression Rating Scale, the Montgomery-Asberg Depression Rating Scale, and the Clinical Global Impression (CGI) severity and improvement measures. RESULTS: Greater improvement was observed after 6 weeks in patients treated with transdermal selegiline than in those given placebo according to all measures. A statistically significant difference between drug and placebo was seen in Hamilton depression scale and Montgomery-Asberg Depression Rating Scale scores as early as week 1 of treatment. There were no differences in the adverse event profile of the patients given selegiline and those given placebo with the exception of application-site reactions, which were more common with the selegiline transdermal system. No orthostatic hypotensive or hypertensive reactions were observed. CONCLUSIONS: Transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed.
Posted by linkadge on February 9, 2006, at 9:18:16
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 15:55:23
You're right, I really don't know untill/if the drug comes out.
Linkadge
Posted by LizinManhattan on February 9, 2006, at 14:35:23
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 19:35:19
Yea, artists have moved into Red Hook so the prices are going up... Where do you live now?
I take it Remeron didn't help you? Do you suffer from atypical depression? That's my problem.
Liz> Cool,im orginaly from redhook.....the old old REDHOOK where you knew your boundaries at night.
>
> LOL i remeber i literaly was the only white face in the entire redhook,but i wouldent have changed it for the world,bad place,but grew up with great great people.
>
> I hear redhook is changing into a very hih class place now anyway im not sure if u said ur going on remeron,all these postins criss crossins i might be confused,BUT just my opintion and i hate to scare you,disapoint you are anything,im just honestly sorry to hear ur choosing remeron,regardless i wish u luck and hope.
Posted by LizinManhattan on February 9, 2006, at 14:38:47
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by gibber on February 8, 2006, at 23:13:36
Hi,
Do you know which journal the study's in? I'd love to read the whole article, and have it for my doctor if necessary.
Thanks!
Liz> one of the only emsam studies I know of. I had an appointment with Dr. Bodkin the study doctor a few months ago and he did recommend the patch to me. He was an amazing person to talk to and no ego. Unfortunately the doctor I have now is the complete opposite but he may give me the emsam when it comes out. Below is the study, the full article is free too:
>
> Transdermal selegiline in major depression: a double-blind, placebo-controlled, parallel-group study in outpatients.
>
> Bodkin JA, Amsterdam JD.
>
> McLean Hospital, 115 Mill St. Belmont, MA 02478, USA. abodkin@mclean.harvard,edu
>
> OBJECTIVE: The authors investigated the efficacy and safety of transdermal selegiline in adult outpatients with major depressive disorder. METHOD: Following a 1-week placebo lead-in, 177 adult outpatients with major depressive disorder were randomly assigned to receive transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) (N=89) or placebo (N=88) for 6 weeks. The patients followed a tyramine-restricted diet during the medication trial and for 2 weeks after completion of treatment. Response to medication or placebo was measured by using the 17-item and 28-item versions of the Hamilton Depression Rating Scale, the Montgomery-Asberg Depression Rating Scale, and the Clinical Global Impression (CGI) severity and improvement measures. RESULTS: Greater improvement was observed after 6 weeks in patients treated with transdermal selegiline than in those given placebo according to all measures. A statistically significant difference between drug and placebo was seen in Hamilton depression scale and Montgomery-Asberg Depression Rating Scale scores as early as week 1 of treatment. There were no differences in the adverse event profile of the patients given selegiline and those given placebo with the exception of application-site reactions, which were more common with the selegiline transdermal system. No orthostatic hypotensive or hypertensive reactions were observed. CONCLUSIONS: Transdermal selegiline (20 mg applied once daily by means of a 20-cm(2) patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed.
>
Posted by gibber on February 9, 2006, at 19:34:26
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » gibber, posted by LizinManhattan on February 9, 2006, at 14:38:47
Here's the link to the full-text article. This is the first study done on the patch. 4 other studies were done later where 2 showed significant difference bwtn patch and placebo and 2 that did not. This single study is very encouraging, however when the studies are combine the authors use the term "modest difference" bwtn patch and placebo.
I think this is another case of what works for some does not work for others. I'm encouraged by the results.http://ajp.psychiatryonline.org/cgi/content/full/159/11/1869
You can find a few more studies at:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
Posted by LizinManhattan on February 9, 2006, at 22:05:56
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by gibber on February 9, 2006, at 19:34:26
Thanks so much for the links. I have bookmarked them and will look at them tomorrow.
Thanks!
Liz> Here's the link to the full-text article. This is the first study done on the patch. 4 other studies were done later where 2 showed significant difference bwtn patch and placebo and 2 that did not. This single study is very encouraging, however when the studies are combine the authors use the term "modest difference" bwtn patch and placebo.
> I think this is another case of what works for some does not work for others. I'm encouraged by the results.
>
> http://ajp.psychiatryonline.org/cgi/content/full/159/11/1869
>
> You can find a few more studies at:
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed
Posted by Larry Hoover on February 10, 2006, at 9:52:40
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 11:48:26
> Mr.hoover aside from the groups and the whole deprenyl/phenylane movement,
>
> wouldent u say it odd your everyday p-doc have any exper with deprenyl and depression prior to emsam.I do agree with that. L-deprenyl was unknown in North America before it became one of the first effective treatments for Parkinson's disease. Dr. Morton Shulman formed a company for the sole purpose of importing this drug under license, so that he could have access to it to treat his own Parkinson's symptoms.
Lar
Posted by Larry Hoover on February 10, 2006, at 10:00:47
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 8, 2006, at 11:58:52
> Sorry i forgot to ask something i very much wanted to,would you say the delivery of a drug directly via bloodstream would avoid the problem of poop out.
>
> My understanding from reading is poop out is when ur body having had just about enough of a foreign substance begins to fight back by building specific anti-enzmyes to keep this substance out and away,hence the longer of introduction of a drug,the more chance your body will start getting wise to it and fighting it.It is possible that the induction of enzymes is at the heart of poop-out, but I wouldn't put that theory at the top of my "probable causes" list. Enzyme induction tends to be rather rapid, if it's going to occur at all. It's part of our defense against toxic substances, and a tardy response to toxicity could well end in death (hypothetical evolutionary perspective). I'm most inclined towards a tolerance-based mechanism for poop-out.
> Would the patch benifit here.
The patch works well in two situations. The first is maintaining stable blood concentration. Oral dosing is characterized by substantial changes in blood concentration, rising rapidly after a dose, and tapering off to a much lower level just prior to the next dose. The second situation is to provide an alternate route of entry into the body, where normal digestive processes would tend to destroy the drug before it could do any good.
> P.S As a note i have seen your postings since i began posting period on the internet approx 5 years ago,guess im giving respect due i dunno,but glad certain people are around,lol you part of the kind that makes me look smart as i read your info and turn around and pass it along,shhhhh thats a secret.Thanks, willyee.
Lar
Posted by willyee on February 10, 2006, at 18:39:31
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » willyee, posted by LizinManhattan on February 9, 2006, at 14:35:23
> Yea, artists have moved into Red Hook so the prices are going up... Where do you live now?
> I take it Remeron didn't help you? Do you suffer from atypical depression? That's my problem.
> Liz
>
I was born in long island collega hospital,and raised in red hook,left at 19 to va beach,about 20/21 i began to notice anxiety and since suffered my entitre 20`s......i am thankful i got tolive a normal teenage life,in ny in my teen years i was a little punk llol but there were a lot of great times,if u had told me then id be on drgus id had laughed at you.In my early twenties i visited many times and after hitting someone on the NJ turnpike at 90 mph in a little jeep tracker i realised it was no longer about missing ny,the disease used the move as its way in,but now its much more than simply going back to ny.
Posted by platinumbride on February 11, 2006, at 3:10:23
In reply to Selegiline/Deprenyl effective anti-depressant?, posted by LizinManhattan on February 7, 2006, at 21:35:15
Liz,
It did nothing for me, but I took it in tablet form. I have read and heard good things about Ensam, and in tablrt form with L-Phenylalanine or PEA (?) - amino acids
Good luck to you...
Diane
Posted by willyee on February 11, 2006, at 20:49:05
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » LizinManhattan, posted by platinumbride on February 11, 2006, at 3:10:23
> Liz,
>
> It did nothing for me, but I took it in tablet form. I have read and heard good things about Ensam, and in tablrt form with L-Phenylalanine or PEA (?) - amino acids
>
> Good luck to you...
>
> DianeYoure right the tab form of deprenyl does not have a good hostory,and this i get from news groups and such,not ur typical documented cases but actual people in groups who used it,which i actualy most times hold more solid anyway.
They do say however the liquid form is a LOT LOT better than the current available tab form,the liquid form because of its realtionship with methamphet is actualy banned in some places like i believe japan.......ive used the liquid form,and in conjunction with other meds its defintaly an active med,least i thought so.
Posted by platinumbride on February 12, 2006, at 7:35:22
In reply to Re: Selegiline/Deprenyl effective anti-depressant?, posted by willyee on February 11, 2006, at 20:49:05
Wilyee,
I didn't know that!
I hope, Liz, that you can get ur hands on some :-)
Diane> > Liz,
> >
> > It did nothing for me, but I took it in tablet form. I have read and heard good things about Ensam, and in tablrt form with L-Phenylalanine or PEA (?) - amino acids
> >
> > Good luck to you...
> >
> > Diane
>
> Youre right the tab form of deprenyl does not have a good hostory,and this i get from news groups and such,not ur typical documented cases but actual people in groups who used it,which i actualy most times hold more solid anyway.
>
> They do say however the liquid form is a LOT LOT better than the current available tab form,the liquid form because of its realtionship with methamphet is actualy banned in some places like i believe japan.......ive used the liquid form,and in conjunction with other meds its defintaly an active med,least i thought so.
Posted by Larry Hoover on February 12, 2006, at 12:38:39
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » gibber, posted by LizinManhattan on February 9, 2006, at 22:05:56
> Thanks so much for the links. I have bookmarked them and will look at them tomorrow.
> Thanks!
> Lizhttp://ajp.psychiatryonline.org/cgi/content/full/159/11/1869
There is a link with reference 21 that takes you to an article with this quotation. I think it makes clear how different the patch is from oral intake....
"In bypassing first-pass metabolism, a 24-hour application of transdermally administered selegiline (7.8 mg/24 hr) yields fifty times greater systemic exposure than is provided by single oral doses."
Lar
Posted by josh37 on February 12, 2006, at 15:21:17
In reply to Selegiline/Deprenyl effective anti-depressant?, posted by LizinManhattan on February 7, 2006, at 21:35:15
I have been dealing with depression for +30 years. I have tried many ssri and tricyclics, and for one reason or another, I cannot take them. SSRI's make me apathetic; tricyclics leave me tired and aggravate my prostate. I tried Wellbutrin, but wound up being allergic to it. I have been doing research on psychopharmacology for years, and as the stuff I have self-medicated with in the past seems to work on the neurotransmitter Dopamine, I thought I'd give the MAO-B inhibitor Selegiline a try. I have been on it a week (5 mg/day) and have not noticed anything. Can anyone tell me if I need a higher dose? I know only 5-10mg is needed for Parkinson's patients--what is the effective dose range for co-morbid anxiety and depression?
Posted by LizinManhattan on February 17, 2006, at 22:29:18
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » LizinManhattan, posted by josh37 on February 12, 2006, at 15:21:17
I'm sorry for your struggle. Unfortunately I can't help you with selegiline. However, maybe post as a new topic altogether and you might get more of a response. Also, have you tried Parnate or Nardil (although I hear the new Nardil is not that great)?
Good luck,
Liz> I have been dealing with depression for +30 years. I have tried many ssri and tricyclics, and for one reason or another, I cannot take them. SSRI's make me apathetic; tricyclics leave me tired and aggravate my prostate. I tried Wellbutrin, but wound up being allergic to it. I have been doing research on psychopharmacology for years, and as the stuff I have self-medicated with in the past seems to work on the neurotransmitter Dopamine, I thought I'd give the MAO-B inhibitor Selegiline a try. I have been on it a week (5 mg/day) and have not noticed anything. Can anyone tell me if I need a higher dose? I know only 5-10mg is needed for Parkinson's patients--what is the effective dose range for co-morbid anxiety and depression?
Posted by LizinManhattan on February 17, 2006, at 22:31:41
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » LizinManhattan, posted by Larry Hoover on February 12, 2006, at 12:38:39
Thank you, Lar! Now I plenty of information with which to do research on what I should take next.
Liz> http://ajp.psychiatryonline.org/cgi/content/full/159/11/1869
>
> There is a link with reference 21 that takes you to an article with this quotation. I think it makes clear how different the patch is from oral intake....
>
> "In bypassing first-pass metabolism, a 24-hour application of transdermally administered selegiline (7.8 mg/24 hr) yields fifty times greater systemic exposure than is provided by single oral doses."
>
> Lar
Posted by gibber on February 18, 2006, at 0:03:16
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » Larry Hoover, posted by LizinManhattan on February 17, 2006, at 22:31:41
Pubmed has one study of adding PEA to selegiline. I wonder if the study doctors were able actually use PEA. The only thing I have found available is its precursor DL-phenyalanine. Heres the link to that study.
Does anyone know how much DL-phenyalanine should be taken with selegiline? Its hard to know since PEA was used in the study.
Posted by josh37 on February 18, 2006, at 11:22:35
In reply to Re: Selegiline/Deprenyl effective anti-depressant? » josh37, posted by LizinManhattan on February 17, 2006, at 22:29:18
Thanks for your input Liz. I have stopped taking selegiline, because I think it was actually making me worse. I think I might start taking DLPA, and am thinking of starting Mirapex.
> I'm sorry for your struggle. Unfortunately I can't help you with selegiline. However, maybe post as a new topic altogether and you might get more of a response. Also, have you tried Parnate or Nardil (although I hear the new Nardil is not that great)?
> Good luck,
> Liz
>
> > I have been dealing with depression for +30 years. I have tried many ssri and tricyclics, and for one reason or another, I cannot take them. SSRI's make me apathetic; tricyclics leave me tired and aggravate my prostate. I tried Wellbutrin, but wound up being allergic to it. I have been doing research on psychopharmacology for years, and as the stuff I have self-medicated with in the past seems to work on the neurotransmitter Dopamine, I thought I'd give the MAO-B inhibitor Selegiline a try. I have been on it a week (5 mg/day) and have not noticed anything. Can anyone tell me if I need a higher dose? I know only 5-10mg is needed for Parkinson's patients--what is the effective dose range for co-morbid anxiety and depression?
>
>
This is the end of the thread.
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