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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by redscarlet on January 11, 2006, at 8:37:20
Do benzos raise prolactin levels ?
Seems that Xanax does....right ?
Do they all raise prolactin levels ?
If not which ones don't.
Thank You... :-)
Posted by Phillipa on January 11, 2006, at 19:31:12
In reply to benzodiazepines prolactin levels, posted by redscarlet on January 11, 2006, at 8:37:20
They do? Fondly, Phillipa
Posted by blueberry on January 12, 2006, at 6:00:58
In reply to benzodiazepines prolactin levels, posted by redscarlet on January 11, 2006, at 8:37:20
> Do benzos raise prolactin levels ?
> Seems that Xanax does....right ?
> Do they all raise prolactin levels ?
> If not which ones don't.
> Thank You... :-)I don't know. I do know what increased prolactin feels like though. I experienced it bigtime with amisulpride and then with deprenyl. Basically, anything that enhances dopamine function a lot does it to me. I have not experienced those feelings while taking xanax. But then, I've only taken xanax in short spurts. You could go to www.pubmed.com and type in the search box "alprazolam AND prolactin" and see what you get.
Posted by cache-monkey on January 13, 2006, at 14:00:00
In reply to Re: benzodiazepines prolactin levels, posted by blueberry on January 12, 2006, at 6:00:58
Interesting. I thought that dopamine function (esp. stimulation of D-2 receptors in certain parts of the brain) was *inversely* associated with prolactin and sexual function. I guess this is another bit of evidence on how differently we respond to meds...
~cache-monkey
> I don't know. I do know what increased prolactin feels like though. I experienced it bigtime with amisulpride and then with deprenyl. Basically, anything that enhances dopamine function a lot does it to me.
Posted by zeugma on January 13, 2006, at 17:12:57
In reply to Re: benzodiazepines prolactin levels » blueberry, posted by cache-monkey on January 13, 2006, at 14:00:00
the reason antipsychotics have hyperprolactinema as a fairly frequent side effect is due to dopamine blockade.
DA agonists such as bromocriptine are prescribed as treatment when this condition occurs spontaneously, i.e. not med induced. I suppose bromocriptine would simply negate the effect of the AP, were it prescribed concurrently.
Benzodiazepines in general appear to lower prolactin levels, with the interesting exception of alprazolam. Check Pub Med.
-z
Posted by redscarlet on January 15, 2006, at 8:23:54
In reply to Re: benzodiazepines prolactin levels » cache-monkey, posted by zeugma on January 13, 2006, at 17:12:57
Zeugma ~ I've put on weight and the only thing I can think of is the fact that I started taking the benzodiazpine alprazolam (Xanax). I started taking it to help me with sleep, taking three 0.25 mg pills at night and I soon found myself needing more to get more sleep. Could this in fact be the cause of my weight gain ?
I do feel more hungry when I get up after taking this also but my doctor says that that is not a side effect nor is the raised prolactin level from it (note: my breast are not effected in any way it's just my weight)
Sorry if I'm just not understanding this, this stuff is a little over my head !!!P.S. ~ Thanks everyone else for your replay too... :-)
Posted by zeugma on January 15, 2006, at 13:12:56
In reply to Re: benzodiazepines prolactin levels » zeugma, posted by redscarlet on January 15, 2006, at 8:23:54
Sorry if I'm just not understanding this, this stuff is a little over my head !!! >>
Over mine too.
I am certain, though, that clonazepam does not raise prolactin levels.
Have you ever tried clonazepam or another benzodiazepine?
-z
Posted by Phillipa on January 15, 2006, at 18:38:37
In reply to Re: benzodiazepines prolactin levels » redscarlet, posted by Phillipa on January 11, 2006, at 19:31:12
Never heard of a benzo putting on wt. But I guess anything is possible. Fondly, Phillipa
Posted by redscarlet on January 15, 2006, at 18:50:15
In reply to Re: benzodiazepines prolactin levels » Phillipa, posted by Phillipa on January 15, 2006, at 18:38:37
> Never heard of a benzo putting on wt. But I guess anything is possible. Fondly, Phillipa
No, a raised prolactin level causing weight gain
from Xanax, that's my question... :-)
Posted by redscarlet on January 15, 2006, at 18:53:24
In reply to Re: benzodiazepines prolactin levels » redscarlet, posted by zeugma on January 15, 2006, at 13:12:56
> Sorry if I'm just not understanding this, this stuff is a little over my head !!! >>
>
> Over mine too.
>
> I am certain, though, that clonazepam does not raise prolactin levels.
>
> Have you ever tried clonazepam or another benzodiazepine?
>
> -z
>No I've only been on Xanax but my pdoc just gave me prosom for sleep so maybe I can give up the Xanax or I will ask for something else next time I'm there... Thanks for your help... :-)
Posted by cache-monkey on January 16, 2006, at 21:07:28
In reply to Re: benzodiazepines prolactin levels » cache-monkey, posted by zeugma on January 13, 2006, at 17:12:57
Ah, I understand that effect with the APs. But it struck me as interesting that the poster had elevated prolactin on selegiline... From what I've read the MAO-B inhibition should lead to increased dopamine concentrations, more D-2 stimulation, and if anything lower prolactin...
~cache-monkey
> the reason antipsychotics have hyperprolactinema as a fairly frequent side effect is due to dopamine blockade.
>
> DA agonists such as bromocriptine are prescribed as treatment when this condition occurs spontaneously, i.e. not med induced. I suppose bromocriptine would simply negate the effect of the AP, were it prescribed concurrently.
>
> Benzodiazepines in general appear to lower prolactin levels, with the interesting exception of alprazolam. Check Pub Med.
>
> -z
Posted by zeugma on January 17, 2006, at 17:43:18
In reply to Re: benzodiazepines prolactin levels » zeugma, posted by cache-monkey on January 16, 2006, at 21:07:28
Ah, I understand that effect with the APs. But it struck me as interesting that the poster had elevated prolactin on selegiline... From what I've read the MAO-B inhibition should lead to increased dopamine concentrations, more D-2 stimulation, and if anything lower prolactin...>>
It's a good question. Deprenyl has effects on serotonin also and I suppose people have different levels of MAO which can result in significant inhibition of MAO-A even at doses of deprenyl that are thought to be MAO-B selective. I have read cases of deprenyl inducing serotonin syndrome in individuals taking purportedly MAO-B- selective doses.
-z
This is the end of the thread.
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