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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Iansf on November 3, 2005, at 12:15:21
The following, from the Center for Nicotine and Tobacco Use Research at Yale, says naltrexone prevents weight gain for people who quit smoking, when used with a nicotine patch. I don't know if the same would apply to combining naltrexone with other meds, but perhaps it would.
"In our original grant, we conducted a dose ranging study of naltrexone in combination with transdermal nicotine replacement therapy. In this study, we found that low dose naltrexone in combination with the nicotine patch reduced weight gain in those who succeeded in smoking cessation, and improved smoking cessation outcomes in a subset of participants who smoked to control their weight. These findings suggest that low dose naltrexone may provide a novel, highly translatable strategy for addressing the needs of weight concerned smokers."
Posted by pseudoname on November 3, 2005, at 18:16:47
In reply to Naltrexone and blocking weight gain, posted by Iansf on November 3, 2005, at 12:15:21
> I don't know if the same would apply to combining naltrexone with other meds, but perhaps it would.
Like APs and ADs that are so often associated with weight gain and even diabetes, you mean? Considering that naltrexone sometimes works as an AD by itself or reverses AD poop-out in combo, this may well be worth considering.
Good luck getting a doc to prescribe it, however. I found great reluctance when I tried.
In my own recent trial of it for depression, I had mild nausea ALL the time. That could be related to the absence of weight-gain in those ex-smokers.
Posted by Iansf on November 3, 2005, at 18:30:17
In reply to Re: Naltrexone and blocking weight gain » Iansf, posted by pseudoname on November 3, 2005, at 18:16:47
> Good luck getting a doc to prescribe it, however. I found great reluctance when I tried.
>But you did find one to do it, right? Or did you cross borders, so to speak?
> In my own recent trial of it for depression, I had mild nausea ALL the time. That could be related to the absence of weight-gain in those ex-smokers.
How much were you taking? Does it cause nausea even at the 3-5mg doses generally recommended on the low-dose naltrexone sites?
Posted by pseudoname on November 3, 2005, at 20:33:57
In reply to Re: Naltrexone and blocking weight gain, posted by Iansf on November 3, 2005, at 18:30:17
> But you did find one to do it, right?
By accident. After a year without meds, I got a new pdoc. I picked her because she was cheap and could see a new patient right away. I thought I'd have to work on her for a few months, bringing in naltrexone articles and so on. At my second appointment, I just *mentioned* naltrexone and she said, "Sure. What dose?" She'd never heard of it for depression, but she was game.
My previous 2 pdocs refused outright. One said no one in the area would prescribe it. (Wrong!) The other was in a major university and said I had to try ECT again first.
Pdocs can drive you nuts.
> How much were you taking?
50 mg/day. The smokers were taking 25 mg, I guess? Even if folks didn't actually feel nauseated, there might be some sub-nausea turn-off regarding food.
I doubt that the 3-5 mg range would cause nausea. It didn't for me when I briefly took it.
This is the end of the thread.
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