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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 13 of 13. This is the beginning of the thread.
Posted by Chairman_MAO on October 22, 2005, at 14:30:04
It seems that it is an orphan drug made by a company called "stuart pharmaceuticals" somewhere in MA. Thus, anyone should be able to get a script for it!
I got this information from the FDA's list of orphan drugs.
I figured this drug might be a great thing to try given how treatment-resistant you are. Do not know how MAOI-compatible it is, though.
Posted by ed_uk on October 22, 2005, at 14:57:53
In reply to attn: SLS: viloxazine is available in the US!, posted by Chairman_MAO on October 22, 2005, at 14:30:04
It looks like you might be able to get hold of viloxazine, your favourite antidepressant :-)
Viloxazine used be be marketed in the UK but it was discontinued a few years back.
~ed
Posted by Declan on October 22, 2005, at 16:13:49
In reply to Attention Adam Canada, posted by ed_uk on October 22, 2005, at 14:57:53
Adam made it sound interesting didn't he. I could do with some of that.
declan
Posted by SLS on October 22, 2005, at 17:28:12
In reply to attn: SLS: viloxazine is available in the US!, posted by Chairman_MAO on October 22, 2005, at 14:30:04
Thanks, C_M.
As best as I can remember, viloxazine is a selective NE uptake inhibitor. It might very well be compatable with an MAOI. However, I would probably have a difficult time convincing my doctor to let me try it while I was still taking Parnate.
I can hardly believe this drug is available.
Thanks for your kind concern. I really appreciate it.
- Scott
Posted by Racer on October 22, 2005, at 19:22:54
In reply to Re: attn: SLS: viloxazine is available in the US! » Chairman_MAO, posted by SLS on October 22, 2005, at 17:28:12
I always gotta ask when it's NE related, since that seems to be key for me.
Got a couple of other questions for you about that, though, but no time now. Later?
Whatcha know about this one, ScottyMeLad?
xoxo
Posted by Phillipa on October 22, 2005, at 21:00:56
In reply to Do you think this might be worth me looking into? » SLS, posted by Racer on October 22, 2005, at 19:22:54
Racer isn't it amazing what Scott knows? Fondly, Phillipa
Posted by SLS on October 22, 2005, at 21:53:44
In reply to Do you think this might be worth me looking into? » SLS, posted by Racer on October 22, 2005, at 19:22:54
Hi Racer.
> I always gotta ask when it's NE related, since that seems to be key for me.
As of today, how would you rate your degree of recovery from depression? What is missing? What is there too much of?
> Whatcha know about this one, Scotty MeLad?
>
> xoxo
Viloxazine has been around for a long time in France. I know virtually nothing about it other than it being touted as being a selective norepinephrine (NE) reuptake inhibitor. It has been my impression that it never became very popular, but that it is probably more effective than reboxetine, another NE reuptake inhibitor. Perhaps viloxaxine is not as "clean" and selective as was once thought. It has not been investigated as intensively over the last ten years and subject to the newer investigative techniques.I'm going to check Medline and Google a bit. I think its indication as an orphan drug in the U.S. is for nacolepsy and cataplexy. Like most of the tricyclic drugs, it suppresses REM sleep.
- Scott
Posted by SLS on October 22, 2005, at 22:21:58
In reply to Re: Do you think this might be worth me looking into? » Racer, posted by Phillipa on October 22, 2005, at 21:00:56
> Racer isn't it amazing what Scott knows? Fondly, Phillipa
Dear Phillipa,
Of course, I am flattererd by your remark, but in reality, there are people who have frequented Psycho-Babble whom I hold in much higher regard for the depth and scope of knowledge and understanding they possess. It is all I can do but to just keep up.
One of the blessings of a forum like Psycho-Babble is that it attracts people possessing varying strengths in specific areas of knowledge. I look to a great many people here to aid in the expansion of my own. Learning is a painstaking endeavor for me because my reading comprehension is so poor. However, I can usually count on people here to put me on the right track.
Bottom line: There are people here who blow me away!
I would also like to add that it is of great value that people should simply share their experiences with their treatments. The anecdotes available here have often supplanted academic contentions when it comes to accuracy and validity.
One last point, if I may. I see EVERYONE here learning and growing as a result of their participation on Psycho-Babble. We learn from each other. It is self-evident that a lack of education or specific knowledge does not equate to a lack of intelligence. I can't tell you how many times the thoughts and theories of a "layman" (which is all that I am, by the way), have struck me as being brilliant. Everyone's thoughts and feelings are important. There is hope in the belief that everyone's combined efforts here yield successes every day.
- Scott
Posted by Racer on October 23, 2005, at 0:44:50
In reply to Re: Do you think this might be worth me looking into? » Racer, posted by SLS on October 22, 2005, at 21:53:44
>
> As of today, how would you rate your degree of recovery from depression? What is missing? What is there too much of?
Well, let's see... I've stopped Lamictal, and am feeling much better for it, and am now reducing Cymbalta to 40mg from 60mg, to see if that will help me get a bit of movement going in my life. I still need a nap daily, which is not very happy making for me, but it's better. I've actually managed to do something pretty much every day for most of the past week, which is a major improvement. So, there's definite progress.Right now, my depression is pretty well controlled. I do get waves of despair, mostly related to my weight and my age, but that sort of thing is in waves now, not constant. (Although those waves are *intense* when they hit. They're mostly related to my weight, though, when they're that bad.) I'm kind of at the point of saying that if I can get to the point of being functional again, I don't care if I'm still somewhat depressed.
What's still a problem, and getting to be more of a problem, is the anxiety. I'm at the point now where I really have to start doing something with my life. It won't be tomorrow, but once my husband's car is running again, I need to have something lined up, to get me out of the house. Being so shut in is not helping me. Problem is, what I know I need to do is terrifying me, and I need to find some way to get that fear under control. Again, if I didn't get those physical symptoms, I could handle any psychological pressure. It's the paralysing fear that stops me.
As much as anything else, I like to have some ideas for what to look at next, for if -- OK, for *when* -- the drugs I'm on now poop out.
Thanks, as always, Scott. You's a good guy.
One last question, if you don't mind:
>> Like most of the tricyclic drugs, it suppresses REM sleep.
I don't know much about sleep phases. What are the results of suppressing REM sleep? And do you know anywhere to start reading up on the subject? REM for Ignoramuses, maybe? ;-D
Posted by SLS on October 23, 2005, at 7:09:17
In reply to Thanks » SLS, posted by Racer on October 23, 2005, at 0:44:50
Hi Racer.
I'm sure you've been told that propranalol can, but not always, produce some depression. However, it sounds like you have found an important place for it in your treatment regime.
R.E.M. = rapid eye movement
There are actually 5 stages of sleep, each having its own unique composition of brain activity:
Stage I
Stage II
Stage III
Stage IV
R.E.M. (Stage V)How the brain cycles through these different phases represents sleep architecture. Each stage can be identified by the brain waves produced. It is during R.E.M. that most, but not all, dreaming occurs. During this stage, the eyes are in constant movement, darting around under the eyelids. In addition, the body goes into a state of cataplexy during R.E.M. It is literally paralyzed such that the body movements you dream of acting out do not translate into actual physical body movement. It is my guess that when dreaming occurs in any of the other phases of sleep, that people actually act out in physical body movements what they are dreaming about.
Sleep is a necessary biological function for survival. It helps to consolidate memories and facilitates learning through long-term potentiation. Sleep is also physically restorative. Some people develop a rare condition that prevents them from sleeping, despite medical intervention. It is fatal.
I found this on the Net. It is not difficult reading - thankfully.
http://serendip.brynmawr.edu/bb/neuro/neuro98/202s98-paper1/Miller.html
Please remind me of some of the drugs you've tried for anxiety:
Klonopin?
Neurontin?
Depakote?
Seroquel?
Abilify?I think it makes sense to lower the dosage of Cymbalta as you have, yet remain on it. It might be that it is this drug that eases the more psychological components of anxiety.
- Scott
Posted by Tom Twilight on October 23, 2005, at 10:50:40
In reply to attn: SLS: viloxazine is available in the US!, posted by Chairman_MAO on October 22, 2005, at 14:30:04
Nice going Chairman
Viloxazine is an AD that I have been interested in for quite a while.
Despite having some similarities with Reboxetine in theory, it sounds quite different in reallity.Viloxazine is one of the few Pro-sexual ADs out there.
Does anyone know of anyway of getting it inported to the UK?
Take care all
Posted by Chairman_MAO on October 25, 2005, at 12:01:06
In reply to Re: attn: SLS: viloxazine is available in the US! » Chairman_MAO, posted by SLS on October 22, 2005, at 17:28:12
There *HAS* to be someting different. Look in the literature or on biopsychiatry.com; it has a distinct pro-sexual effect that NE uptake inhibitors do not have.
Posted by Declan on October 25, 2005, at 15:53:45
In reply to attn: SLS: viloxazine is available in the US!, posted by Chairman_MAO on October 22, 2005, at 14:30:04
Hey, CM, do you think you'd be interested in trying viloxazine? Not with Nardil, I guess.
Declan
This is the end of the thread.
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