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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by tecknohed on September 15, 2005, at 22:51:14
Hi everyone.
Haven't posted for a while. Been feelin better on Nardil but its not without its problems. I felt pretty good for a week or two but its settled down now to 'barely enough'. I'm on 60mg/day. Will go to 75 soon.
Basically I feel unmotivated. And still a bit over shy (I have SP). I'm hoping that with time it'll do its thing PROPERLY.
What I'd like to know is what good augmentation strategies work with Nardil? I feel a mild stimulating/activating med like Modafinil would help alot but I cant see my doc going for that. What about Lithium or Thyroid meds? Or of course ANY others. Any suggestions would be great and especially personal experiences.
If you could rack you brains for a few minutes I'd be most gratefull.
Kind regards, tecknohed.
Posted by Chairman_MAO on September 16, 2005, at 10:59:51
In reply to Nardil Augmentation? (again), posted by tecknohed on September 15, 2005, at 22:51:14
Like I always say, don't bother with augmentation until you've reached 1mg phenelzine per kg bodyweight.
That said, adding an NE uptake inhibitor is probably one of the msot common first-line MAOI augmentation strategies.
Posted by tecknohed on September 16, 2005, at 20:04:16
In reply to Re: Nardil Augmentation? (again) » tecknohed, posted by Chairman_MAO on September 16, 2005, at 10:59:51
Thanx for replies!
Thing I forgot to mention is that I was on 90mg Nardil before I had a temporary switch to Marplan (bad idea). I switched because of the same problem I'm having now - lack of motivation so I've basically returned to where I left off. Though its still the only thing that even 'touches' my SP so seems like I'm better off with it than without it.
I think an amphetamine related drug would be a bad Idea for me cause I've a history of stimulant abuse, plus my doc would NEVER go for it. Though the other meds mentioned (thanx med empowered!) gives me something to look into!
Regards
Posted by Jedi on September 21, 2005, at 3:01:19
In reply to Nardil Augmentation? (again), posted by tecknohed on September 15, 2005, at 22:51:14
>
> Basically I feel unmotivated. And still a bit over shy (I have SP). I'm hoping that with time it'll do its thing PROPERLY.
>
Hey technohed,
I add 1mg of clonazepam to 90mg of Nardil and this seems to help with the social anxiety. I would like to try taking the clonazepam up to 3mg and lower the Nardil to 60mg. This would be an attempt to lessen the sexual and weight gain side effects of Nardil without adding more meds. There is some newer research on using clonazepam augmentation for treatment resistant depression.
Take care,
JediNihon Shinkei Seishin Yakurigaku Zasshi. 2004 Apr;24(2):75-8.
[Clonazepam as a therapeutic adjunct to improve the management of depression]
Morishita S.
Depression Prevent Medical Center, Jujo Hospital, 32 Hattandacho, Kishoin, Minami-ku, Kyoto, 601-8325 Japan.
Clonazepam, which is a benzodiazepine structurally related to chlordiazepoxide hydrochloride, diazepam and nitrazepam, has been available for the treatment of seizure disorders in the USA since 1976 and in Japan since 1981. Increasingly, clonazepam has been used in the treatment of a variety of psychiatric disorders. The effect of clonazepam on depression was first reported by Jones and Chouinard in 1985. Since their report, many investigators have reported on the antidepressive properties of clonazepam. A daily dose of at least 3.0 mg clonazepam in augmentation of ongoing antidepressant treatment should be considered in depression. Regarding clonazepam augmentation therapy, if a patient does not show improvement by the end of four weeks, the treatment regimen should be altered. Age at onset of the first depressive episode and a history of family psychiatric illness should be considered the predictor of prognosis. The author discusses specific guidelines for the use of clonazepam in depression.
Posted by tecknohed on September 21, 2005, at 23:36:35
In reply to Re: Nardil Augmentation? (again) » tecknohed, posted by Jedi on September 21, 2005, at 3:01:19
Yeah, if only! But my UK based pdoc would never give me clonazepam long term, especially haveing a history of acohol/drug addiction. Probably for the best.
It sucks really!
Posted by bigcat on September 23, 2005, at 13:55:29
In reply to Re: Nardil Augmentation? (again) » tecknohed, posted by Jedi on September 21, 2005, at 3:01:19
Tech- I've been in the same exact pickle. Our symptoms and reactions to meds are thoroughly consistant. Dexedrine with Nardil worked brilliantly for a short period, but you're history and the chances for long-term efficacy of this combo seem to sizzle out that avenue. I'm honestly berginning to think I need 150 mgs of Nardil, and I'm neither daring, foolish, or inexperienced. Anyway, I'd appreciate a link to Medempowered's augmentaion recommendations if you or anyone else can post it. Nardil has been an intoxicating, though devastating tease for me.
-matt-
Posted by tecknohed on September 24, 2005, at 6:00:29
In reply to Re: Nardil Augmentation? (again), posted by bigcat on September 23, 2005, at 13:55:29
Hi Bigcat!
Yes it certainly is a TEASE! When you've felt that 'feeling' it gives, you cant help but want it back. I never really ever liked myself much until I took Nardil. Now I wonder whether my success with it was all a dream!?
I would also like to push the dose right up but I've not been back on it for long so I wouldn't want to encourage too many side effects. My pdocs actually looking into a couple of meds for me. He likes the idea of adding respiridone and I've asked him to also look into adding modafinil, which he says his supervisor uses often. Fingers crossed!
As for med_empowered's post, I cant find it anywhere! It seems to have dissappeared from the post/links. If I see it I'll add it to this post strait away.
Take care mate.
Posted by bigcat on September 26, 2005, at 11:09:05
In reply to Re: Nardil Augmentation? (again) » bigcat, posted by tecknohed on September 24, 2005, at 6:00:29
Please elaborate on the Modafinil if you could, teck. I've seen it mentioned often as an augmenting agent, but never learned what it was or when and how it's used effectively. Thanks.
-matt-
Posted by tecknohed on September 26, 2005, at 13:41:39
In reply to Re: Nardil Augmentation? (again), posted by bigcat on September 26, 2005, at 11:09:05
> Please elaborate on the Modafinil if you could, teck. I've seen it mentioned often as an augmenting agent, but never learned what it was or when and how it's used effectively. Thanks.
>
> -matt-
>
>
>
>
I dont know a great deal about it but here is a typical google search result on Modafinil:And of augmentaion:
http://www.modafinil.com/augment-antidepressant.html
And even with an MAOI! (Nardil):
http://ajp.psychiatryonline.org/cgi/content/full/161/9/1716-a
I'm sure you'll find much more through a google search and on here too.
Regards, Kev.
Posted by Muad' Dib on November 11, 2005, at 4:44:24
In reply to Re: Nardil Augmentation? (again) » tecknohed, posted by Chairman_MAO on September 16, 2005, at 10:59:51
> Like I always say, don't bother with augmentation until you've reached 1mg phenelzine per kg bodyweight.
>
> That said, adding an NE uptake inhibitor is probably one of the msot common first-line MAOI augmentation strategies.
Like Reboxetine for example?
Like Reboxetine for example?
This is the end of the thread.
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