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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by denise190466 on September 15, 2005, at 8:15:55
Hi,
Do I really need to wait two weeks after stopping Nardil and going onto 60mg of Seroxat? If so why?
I'm desparate to start something soon.
Thanks.....Denise
Posted by Racer on September 15, 2005, at 12:58:01
In reply to Nardil - Do I really need to wait 2 weeks?, posted by denise190466 on September 15, 2005, at 8:15:55
> Hi,
>
> Do I really need to wait two weeks after stopping Nardil and going onto 60mg of Seroxat? If so why?
>
> I'm desparate to start something soon.
>
>
> Thanks.....DeniseYes. You really do have to wait until the Nardil washes out of your system. You want the monoamine oxydase to build back up in your system. You also don't want to risk elevated SE levels that might lead to Serotonin Syndrome.
Sorry, I know how frustrating that is. Best luck to you.
Posted by linkadge on September 15, 2005, at 16:17:05
In reply to Re: Nardil - Do I really need to wait 2 weeks? » denise190466, posted by Racer on September 15, 2005, at 12:58:01
I rushed onto citalopram after parnate. Bad idea.
Linkadge
Posted by Declan on September 15, 2005, at 19:02:55
In reply to Re: Nardil - Do I really need to wait 2 weeks?, posted by linkadge on September 15, 2005, at 16:17:05
What happened when you did that Linkadge?
Declan
Posted by tecknohed on September 16, 2005, at 0:18:28
In reply to Re: Nardil - Do I really need to wait 2 weeks?, posted by Toonice on September 15, 2005, at 21:27:23
> Its a deep rooted question,depending on where your going next.
>
> Maoi to ssri absolutly,maoi to maoi,well i cant recomend you do so,BUT many many people actualy have taken both at the same time!I switched from isocarboxazid (marplan) back to Nardil recently. I had a 10 day gap and when I restarted the Nardil I had what I can only describe as 'excess Serotonin' for about 3 days. Had I started sooner I think I may have had full blown Serotonin Syndrome, or worse.
Though from what I've read on here, Parnate seems more tolerable combined with other MAOIs.
As for SSRIs, my doc told me he added Sertraline to one of his patients Nardil regiem, and that it "effected him badly", despite there being text and studies on this combo. Luckily his patient was wise enough to stop in time.
Posted by SLS on September 16, 2005, at 8:36:02
In reply to Nardil - Do I really need to wait 2 weeks?, posted by denise190466 on September 15, 2005, at 8:15:55
> Hi,
>
> Do I really need to wait two weeks after stopping Nardil and going onto 60mg of Seroxat?Yes, unfortunately.
> If so why?
Nardil works by permanently shutting-down the factories (MAO enzyme) that are used to break apart excess serotonin in the neuron (nerve cell). The problem is permanence - the factories are essentially destroyed. Even after the last of the Nardil has disappeared from the body, the neurons must still rebuild a supply of factories. This rebuilding process can take two weeks. In the meantime, levels of serotonin begin to build up. When a SSRI or SRI drug is introduced before the factories have been rebuilt and operational, there is a high risk of a dangerous excess of serotonin that accumulates in the synapse (gap between neurons) that can result in a sometimes fatal reaction called serotonin syndrome.
- Scott
>
> I'm desparate to start something soon.
>
>
> Thanks.....Denise
Posted by Chairman_MAO on September 16, 2005, at 10:17:11
In reply to Nardil - Do I really need to wait 2 weeks?, posted by denise190466 on September 15, 2005, at 8:15:55
I'm all for sane washout periods, but in this case unfortunately the washout period is necessary. Nardil is an irreversible MAO, and it takes around two weeks for de novo protein synthesis to make enough MAO to allow you to safely take an SSRI.
Posted by denise1966 on September 18, 2005, at 6:41:33
In reply to Re: Nardil - Do I really need to wait 2 weeks? » denise190466, posted by Chairman_MAO on September 16, 2005, at 10:17:11
Thanks for the responses.
Ok, I'll wait a bit longer, I've got 3 days to go.
Denise
This is the end of the thread.
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