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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by rjlockhart98 on August 21, 2005, at 11:26:26
About 1 year ago i had a rage on Zoloft 150mg, i knocked my dresser half across the room, shartered my window with a barbel. And was about to kill myself.
SSRI at that time made me agitated, becuase i felt that something wasnt stimulated. I was sedated back and I got angry and responded with anger.
Can too much serotonin have these effects, or trigger a manic attack.
Posted by Empathy on August 21, 2005, at 13:45:24
In reply to Being Violent with too much serotonin, posted by rjlockhart98 on August 21, 2005, at 11:26:26
I don't know the exact reason, but I do believe that for some people certain SSRIs can cause rage.
I can only take Prozac - I need the long half life of it, perhaps because I am quick to break down medicines.
I cycled on Paxil, Zoloft and Effexor - up and down - brain zapping - the whole works. I think it was Paxil that made me feel enraged and I am not an angry sort of person.
Posted by linkadge on August 21, 2005, at 17:01:23
In reply to Re: Being Violent with too much serotonin, posted by Empathy on August 21, 2005, at 13:45:24
Yes, SSRi's can definately invoke rage sometimes. Activation of the 5-ht2c receptor can sometimes cause agression by inhibiting activity in the frontal cortex.
MAO-A knockout mice (basically mice with no MAO-A to eat up serotonin and norepinephrine) haver higher levels of serotonin and norepinephrine and are particularly agressive.
There is a link but it is not clearly established.
Linkadge
Posted by bart on August 22, 2005, at 10:43:07
In reply to Being Violent with too much serotonin, posted by rjlockhart98 on August 21, 2005, at 11:26:26
yeah, serotonin syndrome can cause extreme agitation
This is the end of the thread.
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