![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by SLS on July 11, 2005, at 7:50:51
Some people advocate the use of dopamine receptor agonists to treat depression. However, many people end up abandoning them once somnolence develops.
Any comments regarding the use of Mirapex (pramipexole) versus Requip (ropinerole) versus Dostinex (cabergoline) for bipolar depression?
I responded for about 3 days to the addition of bromocriptine to Parnate + desipramine about 10 years ago.
I hate this illness.
>:-<
- Scott
Posted by Declan on July 11, 2005, at 15:07:25
In reply to Mirapex vs Requip vs Donstinex ?, posted by SLS on July 11, 2005, at 7:50:51
Hi Scott
The only dopaminergic agonists I've taken are bromocriptine and Dostinex. Neither made me sleepy, or tired. Dostinex was better because it didn't block up my sinuses. Both made me feel tingly and nice, but I only took them occasionally.
Why do they (those other 2, anyway) cause somnolence?
Declan
Posted by SLS on July 11, 2005, at 21:17:06
In reply to Re: Mirapex vs Requip vs Donstinex ?, posted by Declan on July 11, 2005, at 15:07:25
Hi Declan.
Thanks for replying.
> Why do they (those other 2, anyway) cause somnolence?
The first thought that comes to mind is that postsynaptic receptors are downregulated and made less sensitive while presynaptic autoreceptors remain activated, preventing dopamine synthesis and release.
I really don't know. :-)
- Scott
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.