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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by linkadge on July 4, 2005, at 18:52:01
Linkadge
Posted by iforgotmypassword on July 4, 2005, at 19:06:34
In reply to HIgh MAO-A in depression, posted by linkadge on July 4, 2005, at 18:52:01
wow! so this is a cause suspected to be more common in males? i've definately heard some limited suggestion of certain treatment options being more ideal for a specific sex. more research should go into this, it might lead to effective treatment for otherwise entirely treatment-resistant cases.
Posted by linkadge on July 4, 2005, at 20:19:45
In reply to Re: HIgh MAO-A in depression, posted by iforgotmypassword on July 4, 2005, at 19:06:34
Actually, If I'm not mistaken, there are more links to MAO abnormailities in mood disorders than ther are of the SERT transporter.
Maybe end target is low neurotransmitter, but is one form of increasing it more effective for depression than another ?
Linkadge
Posted by linkadge on July 4, 2005, at 20:27:59
In reply to Re: HIgh MAO-A in depression, posted by linkadge on July 4, 2005, at 20:19:45
http://www.actioncns.com/psychsource/News/Anxiety/article860.htm
Linkadge
Posted by linkadge on July 4, 2005, at 20:37:50
In reply to Re: HIgh MAO-A in depression, posted by linkadge on July 4, 2005, at 20:27:59
Not sure what to make of this....
http://www.ithyroid.com/mao_and_maoi.htm
Quite a few studies have been done on rats showing the effects of manganese on MAO. One study showed that prolonged exposure to low levels of manganese caused MAO to be decreased significantly. Another study showed that manganese given to rats at high levels showed significant reduction in both MAO-A and MAO-B. Another study showed that manganese in rat drinking water decreased dopamine beta-hydoxylase. A study showed manganese-exposed human workers in a ferro-alloy manufacturing plant had lower MAO-B activity. Since manganese is copper and iron antagonist, it appears that the effects of manganese on MAO are mediated by decreasing copper and iron levels.
Posted by linkadge on July 4, 2005, at 20:40:23
In reply to Re: HIgh MAO-A in depression, posted by linkadge on July 4, 2005, at 20:27:59
Not sure what to make of this too. From the same link.
An interesting study showed that there is a Dutch family which has a genetic defect which causes a deficiency of MAO-A (which degrades serotonin and norepi). Norepi increases anger, while serotonin suppresses fear. The men in this family had double the normal levels of norepi and nine times the normal levels of serotonin. The high norepi made them get angry easily and the high serotonin almost completely eliminated any feelings of fear. The result: high aggression and violent behavior. They get angry and have no fear of the consequences of attacking those who make them angry.
Linkadge
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