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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 26. This is the beginning of the thread.
Posted by linkadge on June 5, 2005, at 1:21:11
I know that depression can affect your cognition, but so can these medications. Of all the SSRI's you have taken, which have affected your cognition the least ??
Even though effexor should (in theory at least) affect cognition the least I found it made me extrodinarily foggy ??
Linkadge
Posted by SLS on June 5, 2005, at 10:43:22
In reply to least dumming AD's, posted by linkadge on June 5, 2005, at 1:21:11
> I know that depression can affect your cognition, but so can these medications. Of all the SSRI's you have taken, which have affected your cognition the least ??
>
> Even though effexor should (in theory at least) affect cognition the least I found it made me extrodinarily foggy ??What about Prozac?
I have not tried Luvox nor Celexa. Effexor did make me feel numb and foggy in the beginning, but it dissipated after a few months while taking 300mg. I guess I was lucky.
Zoloft seemed to be OK. I don't remember having trouble with Prozac, although it has been some time since I have tried it. I might not have been as tuned-in to my cognition then as I am now.
Everyone is different in the way they react to medication - trite, I know - but it has become something of a mantra here. However, I believe you will find trends in the way a particular drug affects people. This was a good question to ask. I look forward to reading the responses.
As an aside, I am surprised by how many people have so far answered my question in a negative manner regarding their feelings towards Effexor, despite discounting its potential for producing a withdrawal syndrome upon discontinuation.
If you ever decide to lean in the direction of TCAs, I suffer absolutely no negative effects on cognition with nortriptyline. Imipramine made me dumber than I already am. Desipramine seems to be neutral, as does trimipramine. That's me.
- Scott
Posted by linkadge on June 5, 2005, at 15:35:26
In reply to Re: least dumming AD's, posted by SLS on June 5, 2005, at 10:43:22
What about protryptaline ??, you don't hear much about that one.
Linkadge
Posted by Phillipa on June 5, 2005, at 18:30:17
In reply to Re: least dumming AD's, posted by linkadge on June 5, 2005, at 15:35:26
Luvox was the only one I ever took in therapeutic doses. And I didn't notice any side effects at all. Fondly, Phillipa
Posted by SLS on June 5, 2005, at 19:15:06
In reply to Re: least dumming AD's, posted by linkadge on June 5, 2005, at 15:35:26
> What about protryptaline ??, you don't hear much about that one.
>
>
> Linkadge
Protriptyline and I never got along. I had the most intense anti-cholinergic/pro-noradrenergic side effects of any drug I have ever taken. It also exacerbated my depression severely.
- Scott
Posted by MM on June 5, 2005, at 22:39:33
In reply to Re: least dumming AD's, posted by SLS on June 5, 2005, at 19:15:06
Prozac was the worst for me. I think Paxil was the least dumming for me, maybe Zoloft wasn't too bad. Weird, considering they're pretty closely related I guess.
Posted by SLS on June 6, 2005, at 4:58:39
In reply to Re: least dumming AD's, posted by MM on June 5, 2005, at 22:39:33
> Prozac was the worst for me. I think Paxil was the least dumming for me, maybe Zoloft wasn't too bad. Weird, considering they're pretty closely related I guess.
Paxil was pretty good for me too.
- Scott
Posted by linkadge on June 6, 2005, at 6:30:49
In reply to Re: least dumming AD's, posted by SLS on June 6, 2005, at 4:58:39
Strange, I did thought paxil made me a retard where prozac I was fairly sharp on.
Strange how they affect different people.
Linkadge
Posted by ed_uk on June 6, 2005, at 12:16:38
In reply to Re: least dumming AD's, posted by linkadge on June 6, 2005, at 6:30:49
Hi Link,
Paxil made me very drowsy. It helped my anxiety but I would fall asleep in class.
Ed.
Posted by Phillipa on June 6, 2005, at 16:57:54
In reply to Re: least dumming AD's » linkadge, posted by ed_uk on June 6, 2005, at 12:16:38
Ed, How many mg's of paxil were you on? Fondly,PJ O
Posted by ed_uk on June 7, 2005, at 8:37:28
In reply to Re: least dumming AD's » ed_uk, posted by Phillipa on June 6, 2005, at 16:57:54
Hi PJ,
I tried 20mg, 30mg, 40mg and 60mg. 40mg seemed to work ok for anxiety.
Ed xxx
Posted by Mr.Scott on June 8, 2005, at 1:21:48
In reply to least dumming AD's, posted by linkadge on June 5, 2005, at 1:21:11
Before the neurological problems, Prozac was for me the best.
Scott
Posted by theo on June 8, 2005, at 9:32:53
In reply to Re: least dumming AD's » linkadge, posted by Mr.Scott on June 8, 2005, at 1:21:48
> Before the neurological problems, Prozac was for me the best.
>
> ScottWhat kind of neurological problems did you have on Prozac?
Posted by 4WD on June 8, 2005, at 22:57:57
In reply to Re: least dumming AD's, posted by SLS on June 5, 2005, at 10:43:22
> > I know that depression can affect your cognition, but so can these medications. Of all the SSRI's you have taken, which have affected your cognition the least ??
> >
> > Even though effexor should (in theory at least) affect cognition the least I found it made me extrodinarily foggy ??
>
> What about Prozac?
>
> I have not tried Luvox nor Celexa. Effexor did make me feel numb and foggy in the beginning, but it dissipated after a few months while taking 300mg. I guess I was lucky.
>
> Zoloft seemed to be OK. I don't remember having trouble with Prozac, although it has been some time since I have tried it. I might not have been as tuned-in to my cognition then as I am now.
>
> Everyone is different in the way they react to medication - trite, I know - but it has become something of a mantra here. However, I believe you will find trends in the way a particular drug affects people. This was a good question to ask. I look forward to reading the responses.
>
> As an aside, I am surprised by how many people have so far answered my question in a negative manner regarding their feelings towards Effexor, despite discounting its potential for producing a withdrawal syndrome upon discontinuation.
>
> If you ever decide to lean in the direction of TCAs, I suffer absolutely no negative effects on cognition with nortriptyline. Imipramine made me dumber than I already am. Desipramine seems to be neutral, as does trimipramine. That's me.
>
>
> - Scott
>Nortriptyline made me forgetful. DRiving down the road to a particular place, for example, I'd drive right by the turnoff, go blithely along for a couple miles before it would occur to me where I'd been going. No problems with imipramine that I can remember but that was 20 years ago. None with Celexa or Prozac. Emotional but not cognitive blunting with Effexor. Dumb as a post on Sinequan.
Marsha
Posted by Mr.Scott on June 8, 2005, at 23:17:08
In reply to Re: least dumming AD's » Mr.Scott, posted by theo on June 8, 2005, at 9:32:53
Actually they developed on Zoloft, but now I can't take any of them. Thats okay though I found better alternatives anyways, but fo many years they were a life-saver.
Myoclonus, dystonia, akathisia, apathy, fatigue, and other parkinson's like stuff. Gone though since I stopped taking the drugs, but they re-appear now even at tiny doses. For A while I was in BAD shape!
Scott
Posted by theo on June 9, 2005, at 10:07:10
In reply to Re: least dumming AD's » theo, posted by Mr.Scott on June 8, 2005, at 23:17:08
>
>
> Actually they developed on Zoloft, but now I can't take any of them. Thats okay though I found better alternatives anyways, but fo many years they were a life-saver.
>
> Myoclonus, dystonia, akathisia, apathy, fatigue, and other parkinson's like stuff. Gone though since I stopped taking the drugs, but they re-appear now even at tiny doses. For A while I was in BAD shape!
>
> ScottSo what are your better alternatives?
Posted by Mr.Scott on June 10, 2005, at 2:39:58
In reply to Re: least dumming AD's » Mr.Scott, posted by theo on June 9, 2005, at 10:07:10
Currently I take
.25mg Clonazepam 3x daily
30-50mg Adderall XR
200mg Neurontin at bed time
unilateral ECT once every 1-2 monthsLots of Fish oil.
Works well for me right now. Been on Adderall XR for 6 mos without any tolerance.
Scott
Scott
Posted by theo on June 12, 2005, at 17:15:34
In reply to Re: least dumming AD's » theo, posted by Mr.Scott on June 10, 2005, at 2:39:58
> Currently I take
>
> .25mg Clonazepam 3x daily
> 30-50mg Adderall XR
> 200mg Neurontin at bed time
> unilateral ECT once every 1-2 months
>
> Lots of Fish oil.
>
> Works well for me right now. Been on Adderall XR for 6 mos without any tolerance.
>
> Scott
How's the weight loss with Adderall XR? I've been considering trying it but I DON'T need to lose weight.
Posted by Maxime on June 13, 2005, at 1:42:00
In reply to Re: least dumming AD's » Mr.Scott, posted by theo on June 12, 2005, at 17:15:34
Hi when I was on it, it did lessen my appetite at first but that went away rather quickly. Just make yourself eat. It's the best stim I have taken because I didn't crash on it. I only crashed when they decided to remove it from Canada! LOL!
> How's the weight loss with Adderall XR? I've been considering trying it but I DON'T need to lose weight.
>
Posted by Sarah T. on June 13, 2005, at 3:53:49
In reply to Re: least dumming AD's » theo, posted by Maxime on June 13, 2005, at 1:42:00
Maxime,
Did you say that you didn't crash on Adderall XR or immediate release Adderall? I'm interested to hear that you are having that crashing problem on Dexedrine. That's the opposite of what I experienced (i.e., I didn't crash much on Dexedrine but I crashed terribly on Adderall). Is the Dexedrine you take the name brand or generic? Is it immediate release or sustained release?
Posted by Maxime on June 13, 2005, at 9:07:31
In reply to Re: least dumming AD's » Maxime, posted by Sarah T. on June 13, 2005, at 3:53:49
I didn't crash on 30 mg of Adderall XR. We never had the immediate release tablets.
I use immediate release tablets of Dexedrine, but the generic form. I might have better luck with the spansules, but I might just go straight to Provigil. Oh I should call my doctor now that you have reminded me ...
Maxime
> Maxime,
> Did you say that you didn't crash on Adderall XR or immediate release Adderall? I'm interested to hear that you are having that crashing problem on Dexedrine. That's the opposite of what I experienced (i.e., I didn't crash much on Dexedrine but I crashed terribly on Adderall). Is the Dexedrine you take the name brand or generic? Is it immediate release or sustained release?
Posted by pulse on June 13, 2005, at 15:10:39
In reply to Re: least dumming AD's, posted by Maxime on June 13, 2005, at 9:07:31
another BIG yes vote for prozac as the least dumming.
Posted by Sarah T. on June 13, 2005, at 20:01:24
In reply to Re: least dumming AD's, posted by Maxime on June 13, 2005, at 9:07:31
Hi Maxime.
I think it's worth asking your doctor for a prescription for proprietary or name-brand Dexedrine. I found a huge difference between it and the generic form. Actually, I'm uncertain whether the "generic" one I took was technically "generic." It was called Dextrostat. It washed out much faster than the name-brand for me. I'd suggest giving the name-brand a try before switching to Provigil.
Posted by Sarah T. on June 13, 2005, at 20:27:37
In reply to Re: least dumming AD's, posted by Maxime on June 13, 2005, at 9:07:31
Maxime,
I was wondering why immediate release Adderall was never available in Canada? Do you know why? Someone told me that the immediate release was not available in Canada because it was considered more "abusable" than the sustained release. I find that hard to believe. If abusers are that intent on abusing, I'm sure they'll find a way.Another thing I wanted to mention is that, although I haven't read up on the details of the withdrawal in Canada, I did hear that some children (was it 12 or 14 children?) had died while on Adderall XR. I may be completely wrong, but I suspect that when a thorough investigation is completed, they will find that those deaths were not necessarily caused by Adderall alone. They were probably caused by risky drug combinations that the patients were unable to tolerate due to genetic polymorphisms in liver enzymes and/or the patients had underlying, congenital cardiovascular abnormalities or other predisposing factors for cardiovascular "events."
Posted by Maxime on June 13, 2005, at 22:45:29
In reply to Maxime - question about Adderall, posted by Sarah T. on June 13, 2005, at 20:27:37
I know about the deaths, and that is why Health Canada pulled the med. There were some who had strokes as well.
Who knows why the immediate release tablets were not available. We only had the XR a short time before they pulled it.
:( Can you tell I am not happy about the whole thing?
Maxime
> Maxime,
> I was wondering why immediate release Adderall was never available in Canada? Do you know why? Someone told me that the immediate release was not available in Canada because it was considered more "abusable" than the sustained release. I find that hard to believe. If abusers are that intent on abusing, I'm sure they'll find a way.
>
> Another thing I wanted to mention is that, although I haven't read up on the details of the withdrawal in Canada, I did hear that some children (was it 12 or 14 children?) had died while on Adderall XR. I may be completely wrong, but I suspect that when a thorough investigation is completed, they will find that those deaths were not necessarily caused by Adderall alone. They were probably caused by risky drug combinations that the patients were unable to tolerate due to genetic polymorphisms in liver enzymes and/or the patients had underlying, congenital cardiovascular abnormalities or other predisposing factors for cardiovascular "events."
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