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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by iforgotmypassword on May 5, 2005, at 15:13:29
when do the sedative effects wear off completely? i am particularly prone to them from other meds. (ie. rememron, risperdal, and seroquel knock me out!) how long does it take for the anti-amotivation/anti-rumination effects to start up and at what dose would it be best to take?
im also concerned about the distinct pharmacology of the drug. at low doses does it only target dopamine AUTOreceptors? what other receptors does it target? is it anticholoinergic or anything else wacky as well?
Posted by bark2323 on May 6, 2005, at 16:21:38
In reply to zyprexa pharmac., sedation, AD fx, 5ht** antag. fx, posted by iforgotmypassword on May 5, 2005, at 15:13:29
The sedation wears off after a few weeks in my experience, but I dont experience heavy sedation from it to begin with.
For me, the lowest effective dose was 7.5mg, but that is probably very individual. I take it at 15mg now, which I find very effective. Keep in mind I am a relatively heavy smoker, which results in a significant drop in blood levels of the drug. Im not sure if at low doses it targets mainly autoreceptors, or if that is a special property of only certain APs. I do know that dopamine agonists in general are skewed towards the autoreceptor, but I dont know if that is relevant for antagonists. As for other receptors it antagonizes; D1-4, 5HT-2,3,6, H1, alpha-1, and muscarinic receptors (so it is a bit anticholinergic in theory, but in practice that doesnt seem to be a major problem).
matt
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