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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by krybrahaha78 on February 26, 2005, at 1:38:10
has anyone experienced complete tiredness on ssri's? I have been takin this paxil cr and i am just tired and yawning all day long. Im anxious and tired if that makes any sense. Luvox never made me tired. I have a doc appt on monday and im gonna try to get back on it, but ill have to pay 35 dollars a month for a generic because my new insurance considers it non formulary for some unknown reason, but its worth it.
Posted by stresser on February 26, 2005, at 10:47:27
In reply to SSRI and tiredness, posted by krybrahaha78 on February 26, 2005, at 1:38:10
My daughter took Paxil for a short time but had to discontinue it because it made her very tired. She was falling asleep in class at school. -L
Posted by ed_uk on February 26, 2005, at 13:12:02
In reply to Re: SSRI and tiredness » krybrahaha78, posted by stresser on February 26, 2005, at 10:47:27
Yes, I was absolutely exhausted on Paxil. I slept at the time.
Ed.
Posted by Spriggy on February 26, 2005, at 13:50:08
In reply to Re: SSRI and tiredness » stresser, posted by ed_uk on February 26, 2005, at 13:12:02
Yes. I can't be on SSRI's. They make me tired and yet restless internally at the same time.
It's like my body isn't sure if it's on edge or worn out.
It's not a good feeling.
Posted by meg7 on February 26, 2005, at 14:20:03
In reply to SSRI and tiredness, posted by krybrahaha78 on February 26, 2005, at 1:38:10
How long have you been on paxil? Sometimes it takes a while to get used to a new ssri, and
yet it may not be the right one for you.
Posted by banga on February 26, 2005, at 16:42:15
In reply to Re: SSRI and tiredness, posted by meg7 on February 26, 2005, at 14:20:03
We are all so different. Paxil did not make me tired....it's a good point, if you have only recently started it may be start-up side effects that fade.
Luvox for these first days is making me tired, I am assuming it will subside.
Posted by Phillipa on February 27, 2005, at 0:01:32
In reply to SSRI and tiredness, posted by krybrahaha78 on February 26, 2005, at 1:38:10
Post back on Monday evening. I'm going to ask my Pdoc on Monday also for Luvox. Fondly, Phillipa
Posted by drbill on February 27, 2005, at 12:11:50
In reply to SSRI and tiredness, posted by krybrahaha78 on February 26, 2005, at 1:38:10
Yes, most of them make me sleepy all day long. Never tried Paxil, but Zoloft and Prozac both made me sleepy, Lexapro too at 20 mg. Effexor and Lexapro 10 mg were less sedating. I'm currently trying Cymbalta and have high hopes that it will not be sedating due to its norepinephrine effects and because it "shows minimal affinity for the histamine and cholinergic muscarinic receptors," which I think are the ones that make you sleepy(?).
I pulled together the info on somnolence from the prescribing information for different drugs. My experience hasn't exactly followed the statistics, but it's not too far off. I combined the data for depression and anxiety trials, where available (ie for Lexapro, somnolence was 6% for depression, 12% for anxiety, for an average of 9%). The first number is % of somnolence and the second, in brackets, is abnormal ejaculation, also a major problem with these drugs.
Ranked from least to most sedating:
Wellbutrin 2% [none?]
Cymbalta 7% [3%]
Lexapro 9% [12%]
Prozac 12% [no good data]
Zoloft 13% [14%]
Effexor XR 15.5% [14%]
Luvox 23% [8%]
Paxil CR 23% [13%]
Posted by FredPotter on February 27, 2005, at 13:50:50
In reply to Re: SSRI and tiredness, posted by Spriggy on February 26, 2005, at 13:50:08
Spriggy that's exactly my experience on Cipramil (Celexa). My solution was to supplement with L-Tyrosine 1.5g twice a day 20 minutes before meals. I think SSRIs may deplete Norepinephrine and/or dopamine. That tired/restless feeling is very bad. Good luck Spriggy
Fred
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