Shown: posts 1 to 24 of 24. This is the beginning of the thread.
Posted by tenarc on February 19, 2005, at 22:32:01
I'm just letting you all know that 2 months ago, for the first time in my life I can find relief from my life destroying depression and anxiety. I have been on paxil and then cymbalta, both I hated, while cymbalta made me even more suicidal. two months ago, a friend have 200 caps of hydro codiene. I have been take 3 or 4 per day and I feel wonderful, I am more productive, I love talking to people now, and I love life. Unfortunately I'm going run out, and in desperation I have order perduretas, from europe, which have 30mg of codiene in them. I pray they arrive and not get stolen by customs. Anyways, if you want to buy opieates theres many places online, search perduretas on google and you will find them, and then research on drugbuyers.com to see if they are legitimate.
Posted by SadDoggie on February 20, 2005, at 1:51:33
In reply to opiates, my cure for depression, posted by tenarc on February 19, 2005, at 22:32:01
Everyone knows the euphoria or "well-being" from opiates runs out after awhile and you have to keep raising the dose. So how are you achieving this sustained well-being? If you really wanted to achieve this the only way might be by trying an nmda antagonist like memantine or amantadine with it.
SadDoggie> I'm just letting you all know that 2 months ago, for the first time in my life I can find relief from my life destroying depression and anxiety. I have been on paxil and then cymbalta, both I hated, while cymbalta made me even more suicidal. two months ago, a friend have 200 caps of hydro codiene. I have been take 3 or 4 per day and I feel wonderful, I am more productive, I love talking to people now, and I love life. Unfortunately I'm going run out, and in desperation I have order perduretas, from europe, which have 30mg of codiene in them. I pray they arrive and not get stolen by customs. Anyways, if you want to buy opieates theres many places online, search perduretas on google and you will find them, and then research on drugbuyers.com to see if they are legitimate.
Posted by jerrympls on February 20, 2005, at 2:29:35
In reply to Re: opiates, my cure for depression, posted by SadDoggie on February 20, 2005, at 1:51:33
> Everyone knows the euphoria or "well-being" from opiates runs out after awhile and you have to keep raising the dose. So how are you achieving this sustained well-being? If you really wanted to achieve this the only way might be by trying an nmda antagonist like memantine or amantadine with it.
>
>
> SadDoggie
>
> > I'm just letting you all know that 2 months ago, for the first time in my life I can find relief from my life destroying depression and anxiety. I have been on paxil and then cymbalta, both I hated, while cymbalta made me even more suicidal. two months ago, a friend have 200 caps of hydro codiene. I have been take 3 or 4 per day and I feel wonderful, I am more productive, I love talking to people now, and I love life. Unfortunately I'm going run out, and in desperation I have order perduretas, from europe, which have 30mg of codiene in them. I pray they arrive and not get stolen by customs. Anyways, if you want to buy opieates theres many places online, search perduretas on google and you will find them, and then research on drugbuyers.com to see if they are legitimate.
>
>I have been prescribed opiates for my treatment-resistant depression by my psychiatrist. I've been on various treatments for 13 years. Finally, after showing him research and after HIM doing his own research, he said ok. I don't feel a high when I take them - I just feel normal - not depressed. They're not a miracle cure by any means - I still have a chronic low-grade depression that I'm working on through therapy. I also still have good days and bad days - I'm not always happy. I count my blessings that I have a doctor willing to try this. So far, I am feeling great - not many major downs.
I have been posting my progress with this treatment under the title "The Opiate Trials." I'll post in another couple weeks unless someone asks for more info.
Thanks!
Jerry
Posted by gromit on February 20, 2005, at 5:23:02
In reply to Re: opiates, my cure for depression » SadDoggie, posted by jerrympls on February 20, 2005, at 2:29:35
I am already convinced of the AD effect of opiates. How do you address the tolerance issues though?
Posted by linkadge on February 20, 2005, at 9:50:55
In reply to Re: opiates, my cure for depression » jerrympls, posted by gromit on February 20, 2005, at 5:23:02
Opiates will surely cure depression. They are perhaps the final common molecular destination to pleasure in all sentiant life.
Unfortunately, I have not met anyone who has not *completely* adapted to the effects of opiates.
I'd stay away from them, just in the sence that I just can't see how it would last. Ask Mathew Perry ("Friends") He went through excrutiating rehab after slowly increasing his vicodin prescription to treat depression.
I could be completely wrong, but I don't think opiates are a long term answer by any means.Plus I don't think that an antitolerance meds really work. GLutamate blockers might block the tollerance to the drugs but they can also block the subjective effects of the drugs, by blocking glutamate activity in the Neucleus Accumbens and at the medium spiny neurons.
The only reason I am so adiment is because a little while back I treated my depression with Codiene 30mg tabs. I titrated up to 120mg/day.
After a week (somtimes less) of any dose increase, I would feel no effect. To make things worse, opiate withdrawl caused the *most* profound depression I can even discribe.
You become *hypersensitive* to all pain, physical and emotional.
I'm not trying to bum you out, but I just don't want you to experience what I did.
Linkadge
Posted by ed_uk on February 20, 2005, at 11:01:20
In reply to Re: opiates, my cure for depression » SadDoggie, posted by jerrympls on February 20, 2005, at 2:29:35
Hi Jerry,
I'm really glad to hear that you're doing well :-)
What dose of hydrocodone are you on now? How does it compare to oxycodone?
Ed.
Posted by SadDoggie on February 20, 2005, at 13:14:55
In reply to Re: JERRY........., posted by ed_uk on February 20, 2005, at 11:01:20
Well I'm glad it's helping some of you. I plan to try it soon with memantine or amantadine. I will not go to any high doses, that's just a bad idea. Ed, oxycodone is more potent than hydrocodone and usually on the internet you won't find it, but you can find hydrocodone. Beware of the tylenol that comes with it, it's bad for your liver in large amounts. Plus I'm wary of the more potent ones because I feel like I could get addicted. Better to stick with hydrocodone.
SadDoggie
> Hi Jerry,
>
> I'm really glad to hear that you're doing well :-)
>
> What dose of hydrocodone are you on now? How does it compare to oxycodone?
>
> Ed.
Posted by lunesta on February 20, 2005, at 15:39:26
In reply to opiates, my cure for depression, posted by tenarc on February 19, 2005, at 22:32:01
low-dose naltrexone can do this also, it is quite a cool idea invented for autoimmune diseases, mostly MS.
basically, naltrexone (revia) normally blocks opiate receptors if you overdose or if you must go on extended withdrawl. Using low dose naltrexone at night, you block your own opiate recptors, only at night, and by morning your bodys natural endorphhins floods the receptors creating a similar but natural feeling of opiate from your natural endorphins (like a runners high 24/7 etc..)
Posted by gromit on February 20, 2005, at 20:14:15
In reply to low dose naltrexone also, posted by lunesta on February 20, 2005, at 15:39:26
Thank you for posting about low dose naltrexone, I lost my all my links awhile ago and had forgotten about it. http://www.lowdosenaltrexone.org/
Posted by FredPotter on February 22, 2005, at 13:39:27
In reply to low dose naltrexone also, posted by lunesta on February 20, 2005, at 15:39:26
Lunesta I too have had a cool effect from Naltrexone. It was unexpected too. My problem is where to get it as it's expensive. Also how to get it in tiny doses as this is difficult for a layperson to do
Thanks
Fred
Posted by jerrympls on February 22, 2005, at 18:04:53
In reply to Re: opiates, my cure for depression » jerrympls, posted by gromit on February 20, 2005, at 5:23:02
> I am already convinced of the AD effect of opiates. How do you address the tolerance issues though?
>
>I haven't had any problems with tolerance - and I hope not too. However, I am going to bring up the use of memantine - an NMDA (?) antagonist that is supposed to prevent and/or reverse opiate tolerance.
Posted by jerrympls on February 22, 2005, at 18:09:06
In reply to Re: opiates, my cure for depression, posted by linkadge on February 20, 2005, at 9:50:55
> Opiates will surely cure depression. They are perhaps the final common molecular destination to pleasure in all sentiant life.
>
> Unfortunately, I have not met anyone who has not *completely* adapted to the effects of opiates.
>
> I'd stay away from them, just in the sence that I just can't see how it would last. Ask Mathew Perry ("Friends") He went through excrutiating rehab after slowly increasing his vicodin prescription to treat depression.
>
>
> I could be completely wrong, but I don't think opiates are a long term answer by any means.
>
> Plus I don't think that an antitolerance meds really work. GLutamate blockers might block the tollerance to the drugs but they can also block the subjective effects of the drugs, by blocking glutamate activity in the Neucleus Accumbens and at the medium spiny neurons.
>
> The only reason I am so adiment is because a little while back I treated my depression with Codiene 30mg tabs. I titrated up to 120mg/day.
>
> After a week (somtimes less) of any dose increase, I would feel no effect. To make things worse, opiate withdrawl caused the *most* profound depression I can even discribe.
>
> You become *hypersensitive* to all pain, physical and emotional.
>
> I'm not trying to bum you out, but I just don't want you to experience what I did.
>
>
>
> Linkadge
>
>
>Hi Link-
I agree with your post - and these are the things that my doc and I went over. We agreed the benefits outweighed the risks of tolerance & dependance. I don't think it will be a long-term treatment option - but stranger things have happened.
So far, it's been 2 months on opiates - and no need for increase in dosage. I don't feel them when I take them - they just keep the floor from falling out from under somehow. Yes, I am scared of the depression that follows opiate withdrawl and I guess I'll have to cross that bridge when or if I ever get to it.
Thanks
Jerry
Posted by jerrympls on February 22, 2005, at 18:12:03
In reply to Re: JERRY........., posted by ed_uk on February 20, 2005, at 11:01:20
> Hi Jerry,
>
> I'm really glad to hear that you're doing well :-)
>
> What dose of hydrocodone are you on now? How does it compare to oxycodone?
>
> Ed.Hi Ed!
I'm taking 5mg of hydrocodone 4x daily. Compared to the 10mg of Oxycontin, it has a more stimulating effect for me and has MUCH less mental clouding than oxycodone. Even though I take it 4x daily, it's pretty smooth acting and I don't have many ups & downs. I'm NOT constantly high either - I really don't notice it when I take it.
Jerry ;-)
P.S. Remember I am on Lexapro and Dexedrine as well - so I am sure those are helping as well. Just a reminder that I'm not solely on opiates.
Posted by jerrympls on February 22, 2005, at 18:15:04
In reply to Re: JERRY........., posted by SadDoggie on February 20, 2005, at 13:14:55
> Well I'm glad it's helping some of you. I plan to try it soon with memantine or amantadine. I will not go to any high doses, that's just a bad idea. Ed, oxycodone is more potent than hydrocodone and usually on the internet you won't find it, but you can find hydrocodone. Beware of the tylenol that comes with it, it's bad for your liver in large amounts. Plus I'm wary of the more potent ones because I feel like I could get addicted. Better to stick with hydrocodone.
>
> SadDoggie
>
>
> > Hi Jerry,
> >
> > I'm really glad to hear that you're doing well :-)
> >
> > What dose of hydrocodone are you on now? How does it compare to oxycodone?
> >
> > Ed.
>
>
There is a preparation of hydrocodone without the acetaminophen called HYCODAN. It contains 5mg hydrocodone and 1.5 mg homatropine - an anti-cholinergic (sub-therapeutic level). This is what I am taking.
Posted by jerrympls on February 22, 2005, at 18:17:28
In reply to low dose naltrexone also, posted by lunesta on February 20, 2005, at 15:39:26
> low-dose naltrexone can do this also, it is quite a cool idea invented for autoimmune diseases, mostly MS.
>
> basically, naltrexone (revia) normally blocks opiate receptors if you overdose or if you must go on extended withdrawl. Using low dose naltrexone at night, you block your own opiate recptors, only at night, and by morning your bodys natural endorphhins floods the receptors creating a similar but natural feeling of opiate from your natural endorphins (like a runners high 24/7 etc..)
>
>Hmm...interesting. Thanks lunesta!
Posted by gromit on February 22, 2005, at 19:41:06
In reply to Re: low dose naltrexone also, posted by FredPotter on February 22, 2005, at 13:39:27
> Lunesta I too have had a cool effect from Naltrexone. It was unexpected too. My problem is where to get it as it's expensive. Also how to get it in tiny doses as this is difficult for a layperson to do
http://www.lowdosenaltrexone.org/ has info on compounding pharmacies that will prepare low doses.
Posted by reefer on February 22, 2005, at 19:42:39
In reply to opiates, my cure for depression, posted by tenarc on February 19, 2005, at 22:32:01
I hope i understand you wrong. But what i think you are saying is that you have been taking hydrocodone. And then that you have ordered codeine. Notice that hydrocodone and codeine aren't the same drug. Codeine isn't nearly as potent as hydrocodone. Just wanted to make sure you got to know this, unless i'm getting you wrong.
Posted by Spriggy on February 23, 2005, at 20:32:06
In reply to Re: opiates, my cure for depression, posted by reefer on February 22, 2005, at 19:42:39
Okay, well this explains to me why throughout this horrible depressed state I've been in, when I got a nasty sinus infection/cough, my dr. prescribed some type of liquid cough med with codeine and I felt WONDERFUL...
The whole week I took it (at night before bed), the depression completely ceased.
But isn't it illegal to order that stuff? I would be terribly afraid of getting addicted.
Posted by Iansf on February 27, 2005, at 1:12:05
In reply to Re: opiates, my cure for depression, posted by Spriggy on February 23, 2005, at 20:32:06
What about Suboxone, a combination of bupenorphine and naloxone? It supposedly has low abuse potential. Might it also be effective? (I'm guessing from the name naloxone is related somehow to naltrexone?)
Posted by jerrympls on February 28, 2005, at 19:24:26
In reply to Re: opiates, my cure for depression, posted by Iansf on February 27, 2005, at 1:12:05
> What about Suboxone, a combination of bupenorphine and naloxone? It supposedly has low abuse potential. Might it also be effective? (I'm guessing from the name naloxone is related somehow to naltrexone?)
That was another choice - but so far I'm sticking with the hydrocdone. Tomorrow I see my pdoc - I'll keep you all posted.Jerry
Posted by tenarc on September 12, 2005, at 1:17:57
In reply to opiates, my cure for depression, posted by tenarc on February 19, 2005, at 22:32:01
I'm giving you all an update on my method of using hydrocodone for fighting my depression. I've been on this stuff for about 7 months now and am now going back to college, getting A's, and sleeping wonderful at night. Yes there is a tolerence problem and I have to go cold turky for about 5 days before I begine again, about twice a month I do this. It is aweful and I want to die but I know after 5 days how blissful it will be when i take them again. I take about 10 caps of 10/325 norcos and about 3 at once when i go to bed for a long hard dreamy night of sleep. i hope im not destroying my liver, sometimes i get pain in my uper right abdominal where the liver is ;(.. but if I knew one day i could no longer get anymore norcos because of bush's war on drugs, i would litteraly kill myself. not worth living without feeling sedated and good, not for me... when I detox sometimes I go the full week to be completely back to normal, I just cant believe how much of a reality shift it is, in that i cant even remember what its like to be on hydrocodone and how awful everything is now. maybe someday i can find a heroin dealer, its probably cheaper than spending $400+ a month on pills. so thats my two cents worth, and i pray to the potential of internet pharmacies to continue sending them to me with no records.. although i do have other legitmit pain in my joints and tendonitis which OTC doesn't help. bah im a wreck
Posted by Chairman_MAO on September 13, 2005, at 9:06:33
In reply to Re: opiates, my cure for depression, posted by tenarc on September 12, 2005, at 1:17:57
PLEASE go get yourself a prescription for Suboxone (buprenorphine/noloxone sublingual tabs). A dose of 16mg/day is optimal for most patients. It will provide you with the antidepressant/anxiolytic effect you seek, except you will not feel drugged at all, and there is no tolerance/withdrawal problems. Some people complain of withdrawal symptoms, but I have not experienced them.
You NEED this medication. Please trust me, I know what I'm talking about. Others on this board will vouch for me.
Posted by Declan on September 13, 2005, at 23:46:36
In reply to Re: opiates, my cure for depression » tenarc, posted by Chairman_MAO on September 13, 2005, at 9:06:33
Don't you think hydocodone's a bit special? Better than oxycodone, I think. Never tried bupe.
Declan
Posted by Chairman_MAO on September 16, 2005, at 10:25:53
In reply to Re: opiates, my cure for depression, posted by Declan on September 13, 2005, at 23:46:36
I always liked oxycodone better, although I could see how hydrocodone's stimulant nature could prove better for some people. Frankly, I've tried a lot of opioids (not fentanyl though) and nothing beat heroin. I have heard oxymorphone is generally the best.
Buprenorphine is honestly the best given our current sociopolitical situation re: opioids. Also, it is a kappa antagonist, which confers antipsychotic (and I think additional antidepressant/antimanic properties). It is also advantageous as it does not induce hypogonadism with long-term administration as most full agonists do. See:
http://jcem.endojournals.org/cgi/content/abstract/90/1/203
This is the end of the thread.
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