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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by linkadge on December 31, 2004, at 14:58:05
how is anafranil for anticholinergic side effects?
Linkadge
Posted by ed_uk on December 31, 2004, at 15:13:25
In reply to how is anafranil for anticholinergic side effects?, posted by linkadge on December 31, 2004, at 14:58:05
> how is anafranil for anticholinergic side effects?
Pretty bad apparantly- although not as bad as amitriptyline,
Ed.
Posted by RetiredYoung on December 31, 2004, at 15:20:15
In reply to how is anafranil for anticholinergic side effects?, posted by linkadge on December 31, 2004, at 14:58:05
Here's some direct experience. I was taking clomipramine (generic Anafranil) at 150mg twice per day (i.e. total daily does = 300mg) for several months. I'm currently transitioning off this and on to Cymbalta, precisely because the side effects were overwhelming. For me the s.e.'s included: Heart/cardio (>100 bpm pulse), constipation, shaky hands, **very** dry mouth, urinary hesitation, word slurring/finding (cognitive impairment), exercise (in)tolerance, dizzy when stand up, heartburn, slow weight gain.
I must say though, that clomipramine *did* work well on my core depression/anxiety. I also suffer from frequent headaches, but got no relief from clomipramine in that department.
Please feel free to shoot any other questions about this drug my way...
Jim
Posted by ed_uk on December 31, 2004, at 15:27:37
In reply to Re: how is anafranil for anticholinergic side effects? » linkadge, posted by RetiredYoung on December 31, 2004, at 15:20:15
Studies in vitro showed antidepressant affinities for human muscarinic acetylcholine receptors and therefore the likelihood of antimuscarinic effects to be, in descending order:
amitriptyline
protriptyline
*clomipramine (Anafranil)
trimipramine
doxepin
imipramine
nortriptyline
desipramine
amoxapine
maprotiline
trazodone
Posted by blanding on December 31, 2004, at 18:53:18
In reply to how is anafranil for anticholinergic side effects?, posted by linkadge on December 31, 2004, at 14:58:05
I suffered an extremely dry mouth and therefore discontinued clomipramine.
Posted by francesco on January 27, 2005, at 8:03:26
In reply to Re: how is anafranil for anticholinergic side effe, posted by blanding on December 31, 2004, at 18:53:18
It's quite good for me but I'm taking just 30 mg.
This is the end of the thread.
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