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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by jparsell82` on December 28, 2004, at 2:04:50
Anyone here tried a combination of Milnacipran or Cymbalta with Dostinex or Mirapex? I think Mirapex might have more success combined with Cymbalta or Milnacipran... Mirapex alone decreases bp(for me atleast) and makes me tired.
Here's 2 case reports of the Milnacipran/Cabergoline(Dostinex combo...
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14520161Also, here's an abstract on the this type of combination:
"It is possible that duloxetine (Cymbalta), due to be FDA-licensed in 2005, and milnacipran (Ixel), available in Europe, may be more effective than venlafaxine for a segment of the population that can benefit from dual serotonin-noradrenaline reuptake inhibition. Pain-ridden and melancholic depressives in particular may respond well to this class of drug. Once again, dopaminergic augmentation may be beneficial for the naturally lethargic. Unlike venlafaxine, duloxetine exerts its more balanced serotonin and noradrenaline reuptake inhibition throughout the dosage range. Duloxetine also weakly inhibits the reuptake of dopamine, and shows minimal affinity for the histamine and cholinergic muscarinic receptors. But it takes time to separate genuine therapeutic advance from drug company hype, typically not until the patent expires."It sounds somewhat interesting to me, Duloxetine it says also weakly inhibits reuptake of dopamine... I'm not sure if Milnacipran does. Milnacipran is a little bit stronger of norepinephrine inhibitor though. Anyone tried either of these meds?
Posted by Elroy on January 12, 2005, at 19:45:22
In reply to Milnacipran(Ixel) or Cymbalta + D2/D3 agonist???, posted by jparsell82` on December 28, 2004, at 2:04:50
My psych doc is looking at adding Cymbalta to my current Xanax XR. Have a primary problem with anxiety and secondary with depression. Only have hesitation in some of side effects noted in other postings (sexual and nausea). Would be interested in any type of positive feedback on use of Cymbalta or various combos including Cymbalta. Also, how similar is Cymbalta to Milnacipran?
> Anyone here tried a combination of Milnacipran or Cymbalta with Dostinex or Mirapex? I think Mirapex might have more success combined with Cymbalta or Milnacipran... Mirapex alone decreases bp(for me atleast) and makes me tired.
>
> Here's 2 case reports of the Milnacipran/Cabergoline(Dostinex combo...
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14520161
>
> Also, here's an abstract on the this type of combination:
> "It is possible that duloxetine (Cymbalta), due to be FDA-licensed in 2005, and milnacipran (Ixel), available in Europe, may be more effective than venlafaxine for a segment of the population that can benefit from dual serotonin-noradrenaline reuptake inhibition. Pain-ridden and melancholic depressives in particular may respond well to this class of drug. Once again, dopaminergic augmentation may be beneficial for the naturally lethargic. Unlike venlafaxine, duloxetine exerts its more balanced serotonin and noradrenaline reuptake inhibition throughout the dosage range. Duloxetine also weakly inhibits the reuptake of dopamine, and shows minimal affinity for the histamine and cholinergic muscarinic receptors. But it takes time to separate genuine therapeutic advance from drug company hype, typically not until the patent expires."
>
> It sounds somewhat interesting to me, Duloxetine it says also weakly inhibits reuptake of dopamine... I'm not sure if Milnacipran does. Milnacipran is a little bit stronger of norepinephrine inhibitor though. Anyone tried either of these meds?
Posted by marianna7777 on March 21, 2007, at 20:53:19
In reply to Re: Cymbalta » jparsell82`, posted by Elroy on January 12, 2005, at 19:45:22
I see no answer to the question posted earlier so I decided to post my own and see if I can get any help. What is the difference with Cymbalta and MILNACIPRAN? I was told that Cymbalta did not buy the rights to advertise as a medication for fibromyalgia. Is that correct? Milnacipran/ixel is not yet allowed in the USA but I can order it from the net. Any information that can help me, PLEASE...
> My psych doc is looking at adding Cymbalta to my current Xanax XR. Have a primary problem with anxiety and secondary with depression. Only have hesitation in some of side effects noted in other postings (sexual and nausea). Would be interested in any type of positive feedback on use of Cymbalta or various combos including Cymbalta. Also, how similar is Cymbalta to Milnacipran?
>
>
> > Anyone here tried a combination of Milnacipran or Cymbalta with Dostinex or Mirapex? I think Mirapex might have more success combined with Cymbalta or Milnacipran... Mirapex alone decreases bp(for me atleast) and makes me tired.
> >
> > Here's 2 case reports of the Milnacipran/Cabergoline(Dostinex combo...
> > http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14520161
> >
> > Also, here's an abstract on the this type of combination:
> > "It is possible that duloxetine (Cymbalta), due to be FDA-licensed in 2005, and milnacipran (Ixel), available in Europe, may be more effective than venlafaxine for a segment of the population that can benefit from dual serotonin-noradrenaline reuptake inhibition. Pain-ridden and melancholic depressives in particular may respond well to this class of drug. Once again, dopaminergic augmentation may be beneficial for the naturally lethargic. Unlike venlafaxine, duloxetine exerts its more balanced serotonin and noradrenaline reuptake inhibition throughout the dosage range. Duloxetine also weakly inhibits the reuptake of dopamine, and shows minimal affinity for the histamine and cholinergic muscarinic receptors. But it takes time to separate genuine therapeutic advance from drug company hype, typically not until the patent expires."
> >
> > It sounds somewhat interesting to me, Duloxetine it says also weakly inhibits reuptake of dopamine... I'm not sure if Milnacipran does. Milnacipran is a little bit stronger of norepinephrine inhibitor though. Anyone tried either of these meds?
>
>
Posted by tessellated on March 24, 2007, at 16:22:09
In reply to Cymbalta or MILNACIPRAN » Elroy, posted by marianna7777 on March 21, 2007, at 20:53:19
milnacipran has something closer to a one to one or a one to three ratio of NE to 5HT, whereas cybalta is similar to effexor with a much greater ratio of serotonin to norepinephrine reuptake inhibition.
i don't know why milnacipran isn't in the states, it's very popular in japan due to its lack of sexual side effects. its also thought that it has a lessened "discontinuation syndrome".
its fast acting, and quite safe, and has applications for neuropathic pain, why we have to order over seas is due to FDA or patent approval/cost/profit margin.
most people i've heard prefer milnacipran; cymbalta seems to have more side effects.
Posted by Honore on March 27, 2007, at 21:24:30
In reply to Re: Cymbalta or MILNACIPRAN, posted by tessellated on March 24, 2007, at 16:22:09
At one point, I had heard they were going to introduce it. Then I heard nothing further. My pdoc seemed iffy on it-- who knows why.
I did ask him to prescribe it, so I could get it filled at a European pharmacy, but he didn't trust the European trials, so he demurred. I didn't push it.
Don't know what happened to it, though.
Honore
This is the end of the thread.
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