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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by ed_uk on December 21, 2004, at 11:21:28
Has anyone ever (perhaps very unwisely) taken methylphenidate and dextroamphetamine together?
Has anyone actually been prescribed this combination?
If so, what happened? eg. anxiety, auditory hallucinations, paranoia, hyperthermia, convulsions, hypertension, arrhythmias, excessive stimulation etc.
Ed.
Posted by 3 Beer Effect on December 21, 2004, at 18:06:12
In reply to Methylphenidate + Dextroamphetamine, posted by ed_uk on December 21, 2004, at 11:21:28
I used to snort a combination of 20-40 mg Adderall with 40 mg Ritalin & I must say out of all the drugs i´ve tried, that combo causes a high greater than street methamphetamine. When you mix those two it seems as if 1 + 1 = like 4 instead of 2. It was awesome! You could study for finals for 3 days straight on that combo. (I call this combo a "googleyball". It does cause visual hallucinations (atleast when snorting it) because your pupils are rapidly dialating & then getting smaller over & over. I had an animal house poster on my wall & after snorting that the characters in the poster would move around & look like they were talking. The high was even better if you are drunk at the same time. Interestingly enough, I once mixed street meth with coke to see if it would have the same (additive) effect but to my dissapointment those two actually cancel each other out.
Alas, those were my speed freak/drunken days back in college, lots of fun, but now I work in a respectable office & so must stick to a combo of generic prozac 20 mg + 5 mg selegeline which seems to work well without the downsides of speed addiction (like losing 20+ pounds when you are already a skinny guy).3 Beer Effect
Posted by alohashirt on December 22, 2004, at 0:10:26
I take Concerta on a daily basis and have tried to take Adderall in place but hypertension prevents me (go from 120/74 to 138/88) When I next see my physician I would like to explore exactly the mix you describe. Of course increasing one means decreasing the other. The goal would be to see if he greater efficacy of Adderall could be achieved w/o the hypertension.
> Has anyone ever (perhaps very unwisely) taken methylphenidate and dextroamphetamine together?
>
> Has anyone actually been prescribed this combination?
>
> If so, what happened? eg. anxiety, auditory hallucinations, paranoia, hyperthermia, convulsions, hypertension, arrhythmias, excessive stimulation etc.
>
> Ed.
Posted by lars1 on December 22, 2004, at 3:40:56
In reply to Methylphenidate + Dextroamphetamine, posted by ed_uk on December 21, 2004, at 11:21:28
> Has anyone ever (perhaps very unwisely) taken methylphenidate and dextroamphetamine together?
I haven't, but rats have. Here is a study showing that methylphenidate may actually be neuroprotective against the damage that high-dose amphetamines can otherwise produce. Strange, no?
Lars
J Pharmacol Exp Ther. 2003 Mar;304(3):1181-7.
Methylphenidate alters vesicular monoamine transport and prevents methamphetamine-induced dopaminergic deficits.Sandoval V, Riddle EL, Hanson GR, Fleckenstein AE.
Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
It has been hypothesized that high-dose methamphetamine treatment rapidly redistributes cytoplasmic dopamine within nerve terminals, leading to intraneuronal reactive oxygen species formation and well characterized persistent dopamine deficits. We and others have reported that in addition to this persistent damage, methamphetamine treatment rapidly decreases vesicular dopamine uptake, as assessed in purified vesicles prepared from treated rats; a phenomenon that may contribute to aberrant intraneuronal dopamine redistribution proposedly caused by the stimulant. Interestingly, post-treatment with dopamine transporter inhibitors protect against the persistent dopamine deficits caused by methamphetamine; however, mechanisms underlying this phenomenon have not been elucidated. Also of interest are findings that dopamine transporter inhibitors, including methylphenidate, rapidly increase 1) vesicular dopamine uptake, 2) vesicular monoamine transporter-2 (VMAT-2) ligand binding, and 3) VMAT-2 immunoreactivity in a vesicular subcellular fraction prepared from treated rats. Therefore, we hypothesized that methylphenidate post-treatment might protect against the persistent striatal dopamine deficits caused by methamphetamine by rapidly affecting VMAT-2 and vesicular dopamine content. Results reveal that methylphenidate post-treatment both prevents the persistent dopamine deficits and reverses the acute decreases in vesicular dopamine uptake and VMAT-2 ligand binding caused by methamphetamine treatment. In addition, methylphenidate post-treatment reverses the acute decreases in vesicular dopamine content caused by methamphetamine treatment. Taken together, these findings suggest that methylphenidate prevents persistent methamphetamine-induced dopamine deficits by redistributing vesicles and the associated VMAT-2 protein and presumably affecting dopamine sequestration. These findings not only provide insight into the neurotoxic effects of methamphetamine but also mechanisms underlying dopamine neurodegenerative disorders, including Parkinson's disease.
Free full text at http://jpet.aspetjournals.org/cgi/content/full/304/3/1181
Posted by Dave001 on December 23, 2004, at 21:13:42
In reply to Methylphenidate + Dextroamphetamine, posted by ed_uk on December 21, 2004, at 11:21:28
> Has anyone ever (perhaps very unwisely) taken methylphenidate and dextroamphetamine together?
>Yes. The effects just feel additive.
Posted by Dave001 on December 24, 2004, at 17:46:44
In reply to ritalin + amphetamine, posted by alohashirt on December 22, 2004, at 0:10:26
> I take Concerta on a daily basis and have tried to take Adderall in place but hypertension prevents me (go from 120/74 to 138/88) When I next see my physician I would like to explore exactly the mix you describe. Of course increasing one means decreasing the other. The goal would be to see if he greater efficacy of Adderall could be achieved w/o the hypertension.
What is the total daily amount of methylphenidate (Concerta) that you take? Since you have taken BP readings while on Adderall, I'm assuming you have done so on Concerta as well. If 120/74 is your baseline BP, how much is affected by Concerta (if at all)? Finally, what was the dose of Adderall you were taking, and was it IR or XR?
Dave
Posted by alohashirt on December 25, 2004, at 20:16:18
In reply to Re: ritalin + amphetamine » alohashirt, posted by Dave001 on December 24, 2004, at 17:46:44
Dave,
I typically take 72mg Concerta at 7.00am and
further 10-20mg methylphenidate around 3.00pm.
I see no measurable BP affect from this. I tried
replacing the Concerta with 30mg Adderall XR
for one week and
my BP was all over the place (138/88 135/92 124/110 130/90) but higher.The Concerta does a great job with distraction and impuslivity. At the same time my judgement sometimes seems cloudy and slower, and I can find it harder to context switch. "Robotic" would be an exageration but it's a bit like that.
With Adderall I subjectively felt sharper, and did work of a better quality. At the same time, my distraction was worse and it seemed like too small a dose.
Strattera has been less effective than methylphenidate.
What would you suggest?
> > I take Concerta on a daily basis and have tried to take Adderall in place but hypertension prevents me (go from 120/74 to 138/88) When I next see my physician I would like to explore exactly the mix you describe. Of course increasing one means decreasing the other. The goal would be to see if he greater efficacy of Adderall could be achieved w/o the hypertension.
>
> What is the total daily amount of methylphenidate (Concerta) that you take? Since you have taken BP readings while on Adderall, I'm assuming you have done so on Concerta as well. If 120/74 is your baseline BP, how much is affected by Concerta (if at all)? Finally, what was the dose of Adderall you were taking, and was it IR or XR?
>
> Dave
>
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