Psycho-Babble Medication Thread 423864

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Truly Expert Advice Needed! (MAOI Parnate)

Posted by cubbybear on December 3, 2004, at 10:38:47

While researching the proven disease-inhibiting qualities of the MANGOSTEEN (tropical fruit) rind derivatives, I came upon a technical abstract concluding that Mangosteen (extract from the rind) is, among other things, a SEROTONERGIC RECEPTOR BLOCKING AGENT.

Could anyone elaborate on this and whether-- there'd be any dangerous interaction with MAOI Parnate?
Thanks for the help.

 

Re: Truly Expert Advice Needed! (MAOI Parnate)

Posted by ed_uk on December 3, 2004, at 10:54:25

In reply to Truly Expert Advice Needed! (MAOI Parnate), posted by cubbybear on December 3, 2004, at 10:38:47

Was it this.......

Planta Med. 1996 Oct;62(5):471-2. Related Articles, Links


Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.

Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y.

A crude methanolic extract of the fruit hull of Mangosteen, Garcinia mangostana L. inhibited the contractions of isolated thoracic rabbit aorta induced by histamine and serotonin. The extract of the fruit hull has been fractionated by silica gel chromatography, monitoring the pharmacological activity to give alpha- and gamma-mangostin. On the basis of pharmacological data, it is suggested that alpha-mangostin and gamma-mangostin are a histaminergic and a serotonergic receptor blocking agent, respectively.

Ed.

 

Re: Truly Expert Advice Needed! (MAOI Parnate)

Posted by djmmm on December 3, 2004, at 20:37:36

In reply to Truly Expert Advice Needed! (MAOI Parnate), posted by cubbybear on December 3, 2004, at 10:38:47

5-hydroxy-tryptamine2A receptor gene is relevant to schizophrenia, tardive dyskinesia, major depression, suicidality, anorexia nervosa and obsessive-compulsive disorder (Psychiatric disorders)

Br J Pharmacol 1998 Mar;123(5):855-62

Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice.

Chairungsrilerd N, Furukawa K, Tadano T, Kisara K, Ohizumi Y. Department of Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

1. Intracerebronventricular (i.c.v.) injection of gamma-mangostin (10-40 nmol/mouse), a major compound of the fruit hull of Garcinia mangostana Lin., like ketanserin (10, 20 nmol/mouse, i.c.v.) inhibited 5-fluoro-alpha-methyltryptamine (5-FMT) (45 mg kg(-1), i.p.)-induced head-twitch response in mice in the presence or absence of citalopram (a 5-hydroxytryptamine (5-HT)-uptake inhibitor). 2. Neither the 5-FMT- nor the 8-hydroxy-2-(di-n-propylamino)tetralin (5-HT1A-agonist)-induced 5-HT syndrome (head weaving and hindlimb abduction) was affected by gamma-mangostin or ketanserin. 3. The locomotor activity stimulated by 5-FMT through the activation of alpha1-adrenoceptors did not alter in the presence of gamma-mangostin. 4. 5-HT-induced inositol phosphates accumulation in mouse brain slices was abolished by ketanserin. Gamma-mangostin caused a concentration-dependent inhibition of the inositol phosphates accumulation. 5. Gamma-mangostin caused a concentration-dependent inhibition of the binding of [3H]-spiperone, a specific 5-HT2A receptor antagonist, to mouse brain membranes. 6. Kinetic analysis of the [3H]-spiperone binding revealed that gamma-mangostin increased the Kd value without affecting the Bmax value, indicating the mode of the competitive nature of the inhibition by gamma-mangostin. 7. These results suggest that gamma-mangostin inhibits 5-FMT-induced head-twitch response in mice by blocking 5-HT2A receptors not by blocking the release of 5-HT from the central neurone. Gamma-mangostin is a promising 5-HT2A receptor antagonist in the central nervous system.

 

It Sure Was (nm) ยป ed_uk

Posted by cubbybear on December 4, 2004, at 7:56:24

In reply to Re: Truly Expert Advice Needed! (MAOI Parnate), posted by ed_uk on December 3, 2004, at 10:54:25


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