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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by linkadge on October 30, 2004, at 11:29:31
I think a very good antidepressant would combine a dopaminergic plus potent 5-ht1a agonism.
Linkadge
Posted by SLS on October 30, 2004, at 13:32:03
In reply to dopaminergic + 5-ht1a agonism, posted by linkadge on October 30, 2004, at 11:29:31
> I think a very good antidepressant would combine a dopaminergic plus potent 5-ht1a agonism.
>
> Linkadge
>What about combining:
Wellbutrin or selegiline
+
Buspar or Geodon or AbilifyJust thinking (or not thinking) out loud...
- Scott
Posted by linkadge on October 30, 2004, at 16:01:01
In reply to Re: dopaminergic + 5-ht1a agonism, posted by SLS on October 30, 2004, at 13:32:03
Some interesting combination I have thought of would be the following.
1. RU-486 followed by BDNF injections.
2. Buspar + Selegeline + Xanax (to replicate kava)
3. Buspar + Pindolol (post synaptic agonism +
presynaptic antagonism)4. Buspar + Mirapex + Adrafanil
(5-ht agonist) (da-agonist) (NE-agonist)
Oh if Only I was the one who wrote the perscriptions.............(I might be in a
lot worse shape than what I'm in now !!!!)
Linkadge
Posted by SLS on November 2, 2004, at 16:48:14
In reply to Re: dopaminergic + 5-ht1a agonism, posted by linkadge on October 30, 2004, at 16:01:01
> Some interesting combination I have thought of would be the following.
>
> 1. RU-486 followed by BDNF injections.
>
> 2. Buspar + Selegeline + Xanax (to replicate kava)
>
> 3. Buspar + Pindolol (post synaptic agonism +
> presynaptic antagonism)
>
> 4. Buspar + Mirapex + Adrafanil
> (5-ht agonist) (da-agonist) (NE-agonist)
Very interesting ideas...
> Oh if Only I was the one who wrote the perscriptions.............(I might be in a
> lot worse shape than what I'm in now !!!!)LOL
:-)
- Scott
Posted by banga on November 3, 2004, at 11:57:50
In reply to Re: dopaminergic + 5-ht1a agonism, posted by SLS on November 2, 2004, at 16:48:14
> 4. Buspar + Mirapex + Adrafanil
> (5-ht agonist) (da-agonist) (NE-agonist)
Wait, Adrafanil is an NE agonist, that's its primary action??
Posted by linkadge on November 4, 2004, at 7:39:13
In reply to Re: dopaminergic + 5-ht1a agonism, posted by banga on November 3, 2004, at 11:57:50
It seems to cause a release of glutamate.
Some propose this is related to noradrenic agonistic properties.
Taken from: http://adrafinil.com/adrafinil.html
"Most adrafinil-induced effects (increase in locomotor activity, reduction of immobility duration in the forced swimming test) may correspond to a central alpha 1-adrenergic stimulation"Linkadge
This is the end of the thread.
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