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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by TheOutsider on October 21, 2004, at 6:08:46
I know that MAOIs can be taken with a non serotagenic TCA like Desipramine (unfortunatly desipramine is not available in UK).
I suffer from Inattentive ADD and social anxiety so I was thinking this might be a good combo, but is it feasable?
I also wondered if anyone has found Strattera helpful for motivation?
Any opinions or experience please!
Posted by Kristel on October 21, 2004, at 7:21:40
In reply to Strattera with an MAOI? Any experiences?, posted by TheOutsider on October 21, 2004, at 6:08:46
I tried Reboxetine which is also a noradrenaline reuptake inhibitor. And I find it helpful for motivation, energy, interest and focus. Works fast.
Posted by ed_uk on October 21, 2004, at 11:27:17
In reply to Re: Strattera with an MAOI? Any experiences?, posted by Kristel on October 21, 2004, at 7:21:40
True, desipramine hasn't been available in the UK for about 10 years(approx.) Lofepramine(Gamanil) is available however. Like desipramine, it is also a noradrenaline(norepinephrine) re-uptake inhibitor. Desipramine is the major metabolite of lofepramine. Lofepramine is one of the most popular TCAs in the uk because of its good safety record. It is much less toxic than other TCAs in overdose, which is one of the main reasons for its popularity. It rarely causes sedation and has minimal anticholinergic side effects. Hope this helps...
Ed
Posted by TheOutsider on October 21, 2004, at 11:42:43
In reply to Re: Strattera with an MAOI? Any experiences?, posted by ed_uk on October 21, 2004, at 11:27:17
> True, desipramine hasn't been available in the UK for about 10 years(approx.) Lofepramine(Gamanil) is available however. Like desipramine, it is also a noradrenaline(norepinephrine) re-uptake inhibitor. Desipramine is the major metabolite of lofepramine. Lofepramine is one of the most popular TCAs in the uk because of its good safety record. It is much less toxic than other TCAs in overdose, which is one of the main reasons for its popularity. It rarely causes sedation and has minimal anticholinergic side effects. Hope this helps...
> EdI know that in theory Lofepramine is similar to desipramine....
However I've never heard anyone say its as helpfull as desipramine for energy and motivation, but then its hard to find infomation about lofepramine beyond the basics.
Posted by ed_uk on October 21, 2004, at 12:35:43
In reply to Re: Strattera with an MAOI? Any experiences?, posted by TheOutsider on October 21, 2004, at 11:42:43
True, since lofepramime isn't on the market in the US there aren't many reports of it's use on psychobabble. Even so, from a pharmacological point of view its effects would be expected to resemble desipramine. You could always ask your pharmacy to import some desipramine if your doc was willing to prescribe it.
Ed
Posted by Ilene on October 22, 2004, at 11:30:03
In reply to Re: Strattera with an MAOI? Any experiences?, posted by ed_uk on October 21, 2004, at 12:35:43
> True, since lofepramime isn't on the market in the US there aren't many reports of it's use on psychobabble. Even so, from a pharmacological point of view its effects would be expected to resemble desipramine. You could always ask your pharmacy to import some desipramine if your doc was willing to prescribe it.
> EdDesipramine and MAOIs don't mix. You would have to be very cautious with this combination.
Posted by ed_uk on October 23, 2004, at 17:49:21
In reply to Re: Strattera with an MAOI? Any experiences?, posted by Ilene on October 22, 2004, at 11:30:03
The data sheet for all MAOIs states that they should not be used with tricyclics,including desipramine. Nevertheless, desipramine would be expected to be safer to combine with MAOIs than most other TCAs because it is a selective noradrenaline reuptake inhibitor. The most serious effect of combining an MAOI with a TCA is the serotonin syndrome-but since desipramine has no significant effect on serotonin reuptake this would be very unlikely with desipramine. Even so, combining almost any antidepresants has the potential to be dangerous, serotonin syndrome is not the only risk eg. seizures have been reported when people have recieved AD combinations.
Ed
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