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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by jodeye on June 30, 2004, at 21:22:38
Hi Chemist,
My Dr. said he is now willing to prescribe anything as long as there is at least a small rationale for doing so (for social phobia and hypersomnia).
Several babblers have reported success preventing Adderall tolerance by adding an NMDA antagonist such as memantine, acamprosate, or dextromethorphan.
I am a non-responder to Adderall up to 40mg, except for negative peripheral effects. I have read preclinical statements that memantine can prevent stimulant sensitization, but nothing about tolerance. I have also read that sensitization is often considered to be related to the negative effects, and tolerance related to the positive effects. Maybe my negative response to Adderall could be considered as a preexisting sensitization?
Is the above in agreement with what you know about amphetamines?
Are you able to find anything in the literature that could be considered a rationale for combining amphetamine and an NMDA antagonist?
Thank you.
--Jay
Posted by btnd on July 3, 2004, at 11:00:41
In reply to Question for Chemist re: Adderall tolerance, posted by jodeye on June 30, 2004, at 21:22:38
> Are you able to find anything in the literature that could be considered a rationale for combining amphetamine and an NMDA antagonist?
Search for AmeSansVie posts on amphetamine/adderall tolerance - he had some good references/links.
Here's one abstract:
Psychopharmacology (Berl). 2002 Dec;164(4):376-84. Epub 2002 Oct 05. Related Articles, Links
Effects of the NMDA antagonist memantine on human methamphetamine discrimination.
Hart CL, Haney M, Foltin RW, Fischman MW.New York State Psychiatric Institute, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. clh42@columbia.edu
RATIONALE: The discriminative stimulus effects of N-methyl- D-aspartate (NMDA) antagonists have been assessed in laboratory animals. To date, no published study has assessed their ability to alter methamphetamine-related discriminative stimulus effects in humans. OBJECTIVE: This study investigated the discriminative stimulus, subjective (e.g. "Good Drug Effect"), psychomotor performance, and cardiovascular effects (e.g. blood pressure) of oral methamphetamine following acute oral memantine (a non-competitive NMDA antagonist) in humans.METHODS: Initially, participants were trained to discriminate 10 mg methamphetamine from placebo using a standard two-response procedure (drug versus placebo). Then, the effects of memantine (0, 40 mg) on methamphetamine discrimination were examined across several methamphetamine doses (0, 5, 10, 20 mg) using a novel-response procedure (drug versus placebo versus novel).
RESULTS: Following placebo pretreatment, 10 mg methamphetamine produced 99% methamphetamine-appropriate responding and placebo produced 75% placebo-appropriate responding. Following memantine pretreatment, participants responded as if they had been given a novel compound, although memantine did not significantly alter most subjective-effects ratings following methamphetamine. Memantine alone produced "positive" subjective effects and novel drug-appropriate responding.
CONCLUSION: These data indicate that the memantine-methamphetamine combination produced novel discriminative stimulus effects and that memantine produced some stimulant-like subjective effects.
Posted by jodeye on July 4, 2004, at 2:23:57
In reply to Re: Question for Chemist re: Adderall tolerance » jodeye, posted by btnd on July 3, 2004, at 11:00:41
Thanks,
I've read many of Ames posts, but must have missed some of the references.
I am planning on presenting AndrewBs, Ricks and Ames testimonials, along with whatever medical evidence I can find. Maybe the abstract you provided will be enough :)
--Jay
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