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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by zuzu80 on June 25, 2004, at 17:30:04
Hello,
To all people who used either Provogil (modafinil) or Adrafinil, does it take them days/weeks to start working?
Thanks,
Christine
Posted by Maxime on June 26, 2004, at 19:30:17
In reply to Provogil/Adrafinil - Take long to start working ?, posted by zuzu80 on June 25, 2004, at 17:30:04
What is Adrafinil?
Maxime
> Hello,
>
> To all people who used either Provogil (modafinil) or Adrafinil, does it take them days/weeks to start working?
>
> Thanks,
> Christine
Posted by Rick on June 26, 2004, at 19:42:10
In reply to Provogil/Adrafinil - Take long to start working ?, posted by zuzu80 on June 25, 2004, at 17:30:04
> Hello,
>
> To all people who used either Provogil (modafinil) or Adrafinil, does it take them days/weeks to start working?
>
> Thanks,
> Christine100 mg Provigil started working for me within an hour of my first dose. While everyone's different, if it's going to work for you I'd think you should see an effect at least within a few days. If not, you may need a higher dose. If it still doesn't work, then you're a nonresponder (or are possibly taking something else that can have a metabolic reaction with Provigil, like Celexa).
Rick
Posted by mike0012 on June 27, 2004, at 10:22:54
In reply to Re: Provogil/Adrafinil - Take long to start working ? » zuzu80, posted by Rick on June 26, 2004, at 19:42:10
I just started taking adrafinil a couple weeks ago. I have been taking it on and off. I notice usually the second day I have more interests in things (like chatting online or going out of the apartment), and my mood is better. My ideal dose right now seems to be 600 mg once in the morning. 300mg doesn't give me as good of a benefit, and when i split up the dose i don't think it works as well and makes it hard to fall asleep at night. I haven't tried more than 600mg in one day.
Posted by Dreyfus on June 27, 2004, at 11:24:38
In reply to Re: Provogil/Adrafinil - Take long to start working ?, posted by mike0012 on June 27, 2004, at 10:22:54
Is it ok to take Provigil with Parnate?
Posted by zuzu80 on June 27, 2004, at 12:06:33
In reply to Re: Provogil/Adrafinil - Take long to start working ?, posted by Dreyfus on June 27, 2004, at 11:24:38
Not sure if it's fine to take them together. Adrafinil has direct effect on noradrenergic system and indirect one on dopamine. Might happen that taken together they can produce psychosis (eg hallucinations)
Just a thought, not sure, have no experience....but together they can increase the activity of dopamine even further and therefor the psychotic effects.
Posted by Rick on June 27, 2004, at 18:44:21
In reply to Re: Provogil/Adrafinil - Take long to start working ?, posted by Dreyfus on June 27, 2004, at 11:24:38
> Is it ok to take Provigil with Parnate?
While there is no specific contraindication to taking the two together, the "Interactions" section of the Provigil monograph suggests "caution" using Provigil with MAOI's for the simple reason that there have been no studies of the combination.
At one point I took a very small (2.5 mg) dose of deprenyl/selegiline together with Provigil and Serzone with no problems. Actually, I felt a bit more nervous about the selegiline+Serzone part of the combo than the selegline+Provigil part.
Rick
Posted by Rick on June 27, 2004, at 19:08:22
In reply to Re: Provogil/Adrafinil - Take long to start working ?, posted by zuzu80 on June 27, 2004, at 12:06:33
> Not sure if it's fine to take them together. Adrafinil has direct effect on noradrenergic system and indirect one on dopamine.
Not sure about adrafinil, but here is what the most current Provigil monograph says about its dopminergic and adrenergic activity (or lack thereof):
Modafinil is not a direct- or indirect-acting dopamine receptor agonist and is inactive in several in vivo preclinical models capable of detecting enhanced dopaminergic activity. In vitro, modafinil binds to the dopamine reuptake site and causes an increase in extracellular dopamine, but no increase in dopamine release. In a preclinical model, the wakefulness induced by amphetamine, but not modafinil, is antagonized by the dopamine receptor antagonist haloperidol.
Modafinil does not appear to be a direct or indirect alpha-adrenergic agonist. Although modafinil-induced wakefulness can be attenuated by the a1pha-adrenergic receptor antagonist, prazosin, in assay systems known to be responsive to a1pha-adrenergic agonists, modafinil has no activity.
I think the early view that Provigil acts primarily as an adrenergic agonist is still widely cited even though it has apparently been shown to be untrue.
Rick
Posted by zeugma on June 27, 2004, at 23:08:50
In reply to Re: Provogil/Adrafinil - Take long to start working ? » zuzu80, posted by Rick on June 27, 2004, at 19:08:22
For what it's worth, provigil definitely feels akin to the other stimulants I've taken. It's understandable that the makers of provigil would do their best to obscure Provigil's actual mechanism of action in order to keep its C-IV status intact. That's not to say that Provigil is identical to the other stimulants, but Cephalon cites studies that show that prazosin blocks its stimulant effect on their monograph, but neglects to mention that DAT knockout mice do not get a wakefulness effect either (the study was published in 2001 and i put in a link to it further down the page).
Posted by Rick on June 28, 2004, at 0:38:49
In reply to Re: Provogil/Adrafinil - Take long to start working ? » Rick, posted by zeugma on June 27, 2004, at 23:08:50
> For what it's worth, provigil definitely feels akin to the other stimulants I've taken.
Regardless of mechanism of action, my reaction to Provigil is like night and day vs. Ritalin -- or vs. selegeline, for that matter (which partially metabolizes to methamphetamine). I can't even begin to describe how much gentler Provigil is for me while still keeping me "up". It's hard for me to relate to how it needs to be a controlled substance at all. I've dropped it cold turkey for weeks at a time with no withdrawal effect...just loss of the benefits it brings for my social anxiety, plus of course diminished wakefulness. I love the way I can mentally control the stuff: If I want to take a nap in early afternoon, no problem. But if I want to be wide awake, I am. Maybe it would be different if I weren't taking Klonopin at the same time, but then again, I was on Klonopin when I was taking the other stims, too.
I guess the marked difference between your reaction to Provigil and mine just goes to show for the zillionth time how very differently different folks can react to the same psychoactive meds -- regardless of mechanism of action. Maybe dosage and concomitant meds are a big factor too
Posted by zeugma on June 30, 2004, at 23:46:47
In reply to Re: Provogil/Adrafinil - Take long to start working ? » zeugma, posted by Rick on June 28, 2004, at 0:38:49
> > For what it's worth, provigil definitely feels akin to the other stimulants I've taken.
>
> Regardless of mechanism of action, my reaction to Provigil is like night and day vs. Ritalin -- or vs. selegeline, for that matter (which partially metabolizes to methamphetamine). I can't even begin to describe how much gentler Provigil is for me while still keeping me "up". It's hard for me to relate to how it needs to be a controlled substance at all. I've dropped it cold turkey for weeks at a time with no withdrawal effect...just loss of the benefits it brings for my social anxiety, plus of course diminished wakefulness. I love the way I can mentally control the stuff: If I want to take a nap in early afternoon, no problem. But if I want to be wide awake, I am. Maybe it would be different if I weren't taking Klonopin at the same time, but then again, I was on Klonopin when I was taking the other stims, too.
>
> I guess the marked difference between your reaction to Provigil and mine just goes to show for the zillionth time how very differently different folks can react to the same psychoactive meds -- regardless of mechanism of action. Maybe dosage and concomitant meds are a big factor too
i take 100 mg provigil am, plus clonazepam .5 mg bid, nortriptyline 75 mg pm.i got a free starter pack of provigil, but my pdoc told me that my insurance may not cover it. if not i'm going to start ritalin.
provigil has caused some insomnia, which is a classic stim s/e. I think a lot of the reason for our differing responses to stimulants is that i have severe ADD, and people with ADD often respond to stimulants by being calmed.
i would be happy to stay on provigil, but i actually think that any stimulant would help my condition.
at 100 mg i feel no benefit in wakefulness, so maybe older would be better anyway.
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