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Dr. Bob is Robert Hsiung, MD,
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Posted by krybrahaha on June 4, 2004, at 5:02:14
But how exactly does neurontin work? That’s still largely a mystery to researchers.
“I don’t think we have a full understanding of how it works in the brain at this time,” Dr. Garofalo said. “We believe that it works in the brain and the spinal cord, and we know that it binds to a novel receptor associated with the calcium channels, but we don’t understand the full scientific meaning of that.
“It certainly affects GABA levels, increasing GABA levels in the epilepsy patients who are treated with neurontin. It binds to this receptor that’s called the alpha-2-delta receptor on calcium channels and it reduces polysynaptic neuronal activation. It decreases neuradrenaline and dopamine release, decreases glutamate synthesis and increases the 5-HT concentration in the serotonergic systems.”
In lay terms, neurontin modulates or evens out the nerve messages in the brain and helps the brain respond to impulses at a steady rate.
heres the website:
http://www.immunesupport.com/library/showarticle.cfm/ID/965/T/CFIDS_FM/searchtext/neurontin
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