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Dr. Bob is Robert Hsiung, MD,
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Posted by jaby on June 2, 2004, at 16:44:31
I have trouble with cogniton (not terrible, but troubling) using klonopin and can't seem to reduce my dose any more than I'm at 1.5mg/day. I take other AED's which likely don't help, but klonopin is definitely the culprit. I take wellbutrin SR as well, but that doesn't cut through the dumbness. I'm wondering if a stim might have that capability.
Posted by Chairman_MAO on June 2, 2004, at 19:22:18
In reply to Stim to counter benzo cognition problems?, posted by jaby on June 2, 2004, at 16:44:31
I recommend galantamine (Reminyl, Nivalin), not a stimulant. It has been demonstrated effective against benzodiazepine and ketamine induced dementia. Look in the US patent database for entries including "galantamine" and "clonazepam". You'll see that in the former USSR, they'd do things like use 15mg Klonopin/day + galantamine to treat psychosis. They'd use the galantamine to prevent sedation and cognitive dulling from the whopping dose of Klonopin. Give it a try; I highly doubt you will be disappointed. After all, I tried it on myself when I was taking Klonopin, heh. The only thing you have to watch for is worsening of depression, but if you're stable and you keep the dose minimal, that shouldn't be too much of a problem.
The original galantamine brand, Nivalin, may be ordered directly from Sopharma, AD Bulgaria at www.nivalin.com. I am not affiliated with them in any way; they simply provide a high-quality, reasonably priced alternative to prescription Reminyl in the US.
Posted by Chairman_MAO on June 2, 2004, at 19:30:50
In reply to Re: Stim to counter benzo cognition problems? » jaby, posted by Chairman_MAO on June 2, 2004, at 19:22:18
I believe that benzodiazepines decrease acetylcholine release. Acetylcholine, for the uninitiated, is vital for cognition. The galantamine helps compensate for decreased cholinergic activity.
Akush Ginekol (Sofiia). 1987;26(3):28-31.
[Attempt to eliminate residual somnolence and disorientation with nivaline after anesthesia with ketalar and diazepam for minor obstetrical and gynecologic surgery]
[Article in Bulgarian]
Chakalova E, Marinova M, Srebreva M, Anastasov D, Ploskov K.
PIP: Effectiveness of the anticholinergic agent nivaline to prevent side-effects of anesthetics ketalar and diazepam was studied in 40 pregnant women (15-40 years old) undergoing induced abortion during the 1st trimester. The patients were divided into two groups. Group 1 included 20 patients who received anesthesia with diazepam (10 mg) and ketalar (50-70 mg) alone. Group 2 included 20 patients undergoing anesthesia under diazepam-ketalar in combination with nivaline (10 mg, iv) during an early postoperative period. The degree of somnolence and disorientation was assessed immediately after anesthesia, and 5, 10, 15, 30 and 60 min after surgery using a scale of 1 to 4 (from response to verbal commands and pain stimulus to complete absence of response). The patients in group 2 were more alert than the patients in group 1 only 5, 10 and 15 min after surgery.
Neurosci Lett. 1989 Oct 23;105(1-2):195-9. Related Articles,Links
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