Shown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by linkadge on April 11, 2004, at 9:35:42
I have read that turmeric is a very potent MAO-A inhibitor, and it is cheap as anything. Does anyone know if I should follow the diet on this one ??
Linkadge
Posted by djmmm on April 11, 2004, at 15:02:22
In reply to Using turmeric as MAOI, diet needed ??, posted by linkadge on April 11, 2004, at 9:35:42
> I have read that turmeric is a very potent MAO-A inhibitor, and it is cheap as anything. Does anyone know if I should follow the diet on this one ??
>
>
> LinkadgeI've tried it (for 2 months) along with klonopin....didn't notice much of anything (but I had been on traditional MAOIs previously..kinda like going from Paxil to SJW)
Posted by linkadge on April 11, 2004, at 16:38:09
In reply to Re: Using turmeric as MAOI, diet needed ??, posted by djmmm on April 11, 2004, at 15:02:22
I'm sure noticing somthing but am wondering if a diet is needed.
Is it possible that a MAO inhibitor only affects brain MAO. I mean smoking inibtits MAOA by about 30% but no diet is needed.
Linkadge
Posted by Ame Sans Vie on April 11, 2004, at 18:49:38
In reply to Re: Using turmeric as MAOI, diet needed ??, posted by linkadge on April 11, 2004, at 16:38:09
Actually, smoking inhibits MAO-B. I'd assume the restrictions for turmeric would be the same as those for brofaromine, moclobemide, pargyline, etc.
Posted by mistermindmasta on April 11, 2004, at 21:41:18
In reply to Re: Using turmeric as MAOI, diet needed ?? » linkadge, posted by Ame Sans Vie on April 11, 2004, at 18:49:38
Is turmeric really potent enough to have positive effects on inhibiting MAO levels? I realise that it does have MAO inhibitors, but in concentrations that are useful?
I'm wondering b/c my depression is probably closest to a mix of atypical depression, and MOA's are the best for that.
Have you guys heard of anyone else using it? I'm curious and might consider trying it myself.
Posted by Dr. Bob on April 12, 2004, at 7:59:50
In reply to Using turmeric as MAOI, diet needed ??, posted by linkadge on April 11, 2004, at 9:35:42
> I have read that turmeric is a very potent MAO-A inhibitor...
I'd like to redirect this thread to Psycho-Babble Alternative. Here's a link:
http://www.dr-bob.org/babble/alter/20040225/msgs/335443.html
Thanks,
Bob
Posted by linkadge on April 12, 2004, at 8:08:22
In reply to Doing Better, posted by linkadge on April 12, 2004, at 8:06:11
http://biopsychiatry.com/smokmaoa.htm
Linkadge
Posted by noa on April 12, 2004, at 8:38:05
In reply to Smoking does inhibit MAOA too- study, posted by linkadge on April 12, 2004, at 8:08:22
>http://biopsychiatry.com/smokmaoa.htm
>Linkadge
Hey, that is interesting! Thanks for the link.
Posted by Sad Panda on April 12, 2004, at 20:50:24
In reply to Re: Smoking does inhibit MAOA too- study » linkadge, posted by noa on April 12, 2004, at 8:38:05
> >http://biopsychiatry.com/smokmaoa.htm
> >Linkadge
>
>
> Hey, that is interesting! Thanks for the link.
>
>I am pretty sure I spiralled in to depression after quitting smoking.
Cheers,
Panda.
Posted by SLS on April 13, 2004, at 8:07:23
In reply to Smoking does inhibit MAOA too- study, posted by linkadge on April 12, 2004, at 8:08:22
My guess is that any MAO inhibition produced by smoking is negligable. I think the important property of nicotine to focus in on is its ability to increase the release of dopamine in the limbic system.
- Scott
Posted by Sad Panda on April 13, 2004, at 8:29:30
In reply to Re: Smoking does inhibit MAOA too- study, posted by SLS on April 13, 2004, at 8:07:23
> My guess is that any MAO inhibition produced by smoking is negligable. I think the important property of nicotine to focus in on is its ability to increase the release of dopamine in the limbic system.
>
>
> - Scott
>
>"Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%)"
Surely 28% is more than negligable?
Posted by SLS on April 13, 2004, at 9:02:02
In reply to Re: Smoking does inhibit MAOA too- study » SLS, posted by Sad Panda on April 13, 2004, at 8:29:30
> > My guess is that any MAO inhibition produced by smoking is negligable. I think the important property of nicotine to focus in on is its ability to increase the release of dopamine in the limbic system.
> > "Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%)"
> Surely 28% is more than negligable?28% is certainly not negligible. I question the validity of the results and their interpretation, and I would want to see corroborative evidence offered by someone other that Fowler before embracing this notion as fact. I'll try to research the matter further if I have time today. For as long as I can remember, I have seen just about every drug declared to be an inhibitor of MAO at one point or another, including the tricyclics.
- Scott
Posted by Sad Panda on April 13, 2004, at 9:51:15
In reply to Re: Smoking does inhibit MAOA too- study, posted by SLS on April 13, 2004, at 9:02:02
> > > My guess is that any MAO inhibition produced by smoking is negligable. I think the important property of nicotine to focus in on is its ability to increase the release of dopamine in the limbic system.
>
> > > "Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%)"
>
> > Surely 28% is more than negligable?
>
> 28% is certainly not negligible. I question the validity of the results and their interpretation, and I would want to see corroborative evidence offered by someone other that Fowler before embracing this notion as fact. I'll try to research the matter further if I have time today. For as long as I can remember, I have seen just about every drug declared to be an inhibitor of MAO at one point or another, including the tricyclics.
>
>
> - Scott
>
>The experiment looks more scientific than the typical double blind study sponsored by the pill maker. If it was sponsored by Malboro I'd be more skeptical & I'm pretty sure my depression increased with giving up smoking.
Cheers,
Panda.
Posted by SLS on April 13, 2004, at 10:41:00
In reply to Re: Smoking does inhibit MAOA too- study » SLS, posted by Sad Panda on April 13, 2004, at 9:51:15
Here is an interesting citation relating to smoking cessation. I have found some others suggesting that substances other than nicotine are responsible for the reported MAO inhibition. However, I'm still skeptical as to how important this is relative to the contribution that nicotine has on increasing dopaminergic activity in the limbic system.
- Scott
Posted by SLS on April 13, 2004, at 10:42:23
In reply to Re: Smoking does inhibit MAOA too- study » Sad Panda, posted by SLS on April 13, 2004, at 10:41:00
> Here is an interesting citation relating to smoking cessation. I have found some others suggesting that substances other than nicotine are responsible for the reported MAO inhibition. However, I'm still skeptical as to how important this is relative to the contribution that nicotine has on increasing dopaminergic activity in the limbic system.
Oops. I forgot to post the URL.
Posted by linkadge on April 13, 2004, at 16:17:04
In reply to Re: Smoking does inhibit MAOA too- Oops., posted by SLS on April 13, 2004, at 10:42:23
Yes dopamine has it's place in depression, but serotonin also is key in depression.
Yes if you have apathy or atypical depression, a dopaminergic boost is perhaps what is needed.
But for many, it is the activity of serotonin (to inhibit nerve activity) which is theraputic.
To say that dopamine is the final destination of antidepressants is partially flawed. One major component of depression is anxiety, and amphetamine would do very little for my anxiety, however a MAOA inhibitor might do much more for my anxiety.
People tend to think that everybody thinks the same way they do. Just because one person gets relief from a dopaminergic, does not mean everybody will.
I've heard many people compain that they get major anxiety if they quit smoking. I would assume this is because of the drop in serotonin.
Linkadge
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