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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by Racer on March 27, 2004, at 23:27:54
Just curious, since I can see how stress affects my body. I can't seem to find any references to drugs to reduce cortisol, but I'm betting there's something out there. Anyone know what it might be?
Thanks
Posted by snapper on March 27, 2004, at 23:39:41
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
Racer I too have recently been onto that exact same idea and I know that there must be an answer, although it may not neccessarily be a 'drug' I am searching for answers> let me know if you find any validating info!
Thanks
snapper
Posted by Survector on March 28, 2004, at 0:11:19
In reply to Re: Any drugs reduce cortisol?, posted by snapper on March 27, 2004, at 23:39:41
Stablon (tianeptine) reduces cortisol output from the HPA axis. You can do a search for it on google.
Posted by PsychoSage on March 28, 2004, at 0:28:03
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
> Just curious, since I can see how stress affects my body. I can't seem to find any references to drugs to reduce cortisol, but I'm betting there's something out there. Anyone know what it might be?
>
> Thanks
I think there is a free one called meditation.Try the classic: _The Relaxation Response_ Herbert Benson
It's short and sweet. My pdoc suggested it, and my student health doc did too many years ago.
You've just gave me motivation to get it back from my sister with hypertension.
Posted by rod on March 28, 2004, at 4:35:40
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
Well, a word about Tianeptine. Know the famous study with the tree shrews and their hippocampal volume? Tianeptine actually *increased* cortisol in this study:
"Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine"
http://www.pnas.org/cgi/content/full/98/22/12796"...Stress-Induced Activation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis. Psychosocial stress induced a sustained activation of the HPA axis, as indicated by the nonadapting elevation of urinary cortisol excretion in the two stress groups (Table 2). No statistical differences between the Stress and Stress + Tianeptine group were found, except on week 4 yielding significantly *higher* cortisol excretion (P < 0.02) in stressed animals treated with tianeptine. Despite the daily treatment of subordinate animals with tianeptine (Stress + Tianeptine), cortisol did not return to basal levels (Table 2). This finding is in line with one study in rats showing that stress-elicited elevations in plasma corticosterone were *not* reduced by tianeptine treatment (39). Other studies, however, demonstrated that tianeptine clearly reduces HPA response to stress (40). No effects on urinary cortisol excretion were observed in animals of the two control groups (Control; Control + Tianeptine)..."
The numbers: http://www.pnas.org/cgi/content-nw/full/98/22/12796/T2
So you can see that there are some studies which demonstate a reduction while others demonstated no effect or even an increase in cortisol.
Other drugs that really (as far as I know ;-) ) decrease cortisol are:
Imipramine
Remeron
TrimipramineI guess there are some more.
Roland
Posted by Survector on March 28, 2004, at 8:05:53
In reply to Re: Any drugs reduce cortisol?, posted by rod on March 28, 2004, at 4:35:40
As a current user of tianeptine, I can say that it calms me down and relieves my anxiety in a way that most other antidepressants have not. From my experience, it does indeed appear to reduce cortisol levels (though it doesn't do much else aside from that - it is a weak 'atypical' antidepressant).
Posted by SLS on March 28, 2004, at 13:18:06
In reply to Re: Any drugs reduce cortisol?, posted by Survector on March 28, 2004, at 8:05:53
The first two to come to mind are:
ketaconozole
mifepristone
- Scott
Posted by zero on March 28, 2004, at 21:54:26
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
Posted by jparsell82 on March 29, 2004, at 13:10:23
In reply to Phosphatidylserine (nm), posted by zero on March 28, 2004, at 21:54:26
I think Dilantin reduces cortisol. Plus you can find it pretty cheap.
Posted by LynneDa on March 29, 2004, at 15:42:08
In reply to Any drugs reduce cortisol?, posted by Racer on March 27, 2004, at 23:27:54
I just read something in a magazine called "First for Women" about Cortitrol, a medicine that stabilizes cortisol levels. Not a scientific journal by any means, but you never know where your next good idea will come from!
It allowed the woman in the article to regain her energy levels and lose weight. They quoted it as being about $35 a bottle, I think. The article gave a very nice explanation of stress, our adrenal function and the role of cortisol.
Hope this helps. I intend on looking into it!
~ Lynne
>>>>>>>>>>>>>>>>>>>>>
Just curious, since I can see how stress affects my body. I can't seem to find any references to drugs to reduce cortisol, but I'm betting there's something out there. Anyone know what it might be?
>
> Thanks
Posted by sukarno on April 14, 2005, at 6:51:24
In reply to Re: Any drugs reduce cortisol? » Racer, posted by LynneDa on March 29, 2004, at 15:42:08
Tianeptine (Stablon) reduces cortisol. It's also good for asthma and depression. Works well for me but makes me a bit nervous at the recommended dose, so I had to lower it.
Posted by rod on April 14, 2005, at 8:16:40
In reply to Re: Any drugs reduce cortisol?, posted by sukarno on April 14, 2005, at 6:51:24
> Tianeptine (Stablon) reduces cortisol. It's also good for asthma and depression. Works well for me but makes me a bit nervous at the recommended dose, so I had to lower it.
Well, look at my post earlier at this thread.
http://www.dr-bob.org/babble/20040325/msgs/329357.htmlthe tianeptine - cortisol stuff isnt clear at all..
Roland
Posted by Paulbwell on April 14, 2005, at 10:04:20
In reply to Re: Any drugs reduce cortisol? » sukarno, posted by rod on April 14, 2005, at 8:16:40
Posted by rod on April 14, 2005, at 21:11:17
In reply to Nicotine does, smoking or gum (nm) » rod, posted by Paulbwell on April 14, 2005, at 10:04:20
Posted by Declan on April 14, 2005, at 23:01:28
In reply to Re: Any drugs reduce cortisol?, posted by sukarno on April 14, 2005, at 6:51:24
GH3/KH3?
Posted by TamaraJ on April 14, 2005, at 23:24:11
In reply to Nicotine does, smoking or gum (nm) » rod, posted by Paulbwell on April 14, 2005, at 10:04:20
perhaps better to avoid smoking and use the patch, lozenges or inhaler for nicotine.
Brain monoamine oxidase A inhibition in cigarette smokers
by Fowler JS, Volkow ND, Wang GJ, Pappas N, Logan J, Shea C, Alexoff D, MacGregor RR,
Schlyer DJ, Zezulkova I, Wolf AP
Chemistry Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA.
fowler@simbrain.chm.bnl.gov
J Addict Dis 1998; 17(1):23-34ABSTRACT
Several studies have documented a strong association between smoking and depression. Because cigarette smoke has been reported to inhibit monoamine oxidase (MAO) A in vitro and in animals and because MAO A inhibitors are effective antidepressants, we tested the hypothesis that MAO A would be reduced in the brain of cigarette smokers. We compared brain MAO A in 15 nonsmokers and 16 current smokers with [11C]clorgyline and positron emission tomography (PET). Four of the nonsmokers were also treated with the antidepressant MAO inhibitor drug, tranylcypromine (10 mg/day for 3 days) after the baseline PET scan and then rescanned to assess the sensitivity of [11C]clorgyline binding to MAO inhibition. MAO A levels were quantified by using the model term lambda k3 which is a function of brain MAO A concentration. Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%). The mean lambda k3 values for the whole brain were 0.18 +/- 0.04 and 0.13 +/- 0.03 ccbrain (mlplasma)-1 min-1 for nonsmokers and smokers, respectively; P < 0.0003). Tranyl-cypromine treatment reduced lambda k3 by an average of 58% for the different brain regions. Our results show that tobacco smoke exposure is associated with a marked reduction in brain MAO A, and this reduction is about half of that produced by a brief treatment with tranylcypromine. This suggests that MAO A inhibition needs to be considered as a potential contributing variable in the high rate of smoking in depression and in the development of more effective strategies for smoking cessation.----------------
Inhibition of monoamine oxidase B
in the brains of smokers
by Fowler JS, Volkow ND, Wang GJ, Pappas N,
Logan J, MacGregor R, Alexoff D, Shea C, Schlyer D, Wolf AP, Warner D, Zezulkova I, Cilento R
Brookhaven National Laboratory, Upton, New York 11973, USA. Nature 1996 Feb 22; 379(6567):733-6ABSTRACT
The massive health problem associated with cigarette smoking is exacerbated by the addictive properties of tobacco smoke and the limited success of current approaches to cessation of smoking. Yet little is known about the neuropharmacological actions of cigarette smoke that contribute to smoking behaviour, or why smoking is so prevalent in psychiatric disorders and is associated with a decreased risk of Parkinson's disease. Here we report that brains of living smokers show a 40% decrease in the level of monoamine oxidase B (MAO B; EC 1.4.3.4) relative to non-smokers or former smokers. MAO B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviours as well as movement. MAO B inhibition is therefore associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species. We propose that reduction of MAO B activity may synergize with nicotine to produce the diverse behavioural and epidemiological effects of smoking.------------------------------
Tamara
Posted by Paulbwell on April 14, 2005, at 23:33:36
In reply to Re: Nicotine does, smoking or gum - Actually . . . » Paulbwell, posted by TamaraJ on April 14, 2005, at 23:24:11
> perhaps better to avoid smoking and use the patch, lozenges or inhaler for nicotine.
>
>Yes save ya lungs and use other Nicotine products for reduced Mao b inhibition benefitsAgreed
Smoking-Freebasing Nicotine, works instantly, BUT smells, and can't be used in most indoors places now anyways.
Posted by sukarno on April 15, 2005, at 0:48:45
In reply to Re: Nicotine does, smoking or gum - Actually . . . » TamaraJ, posted by Paulbwell on April 14, 2005, at 23:33:36
Nicotine raises cortisol as far as I know.
http://www.google.com/search?sourceid=mozclient&ie=utf-8&oe=utf-8&q=nicotine+raises+cortisolAbout tianeptine: I was reading yesterday some abstracts that scared me. It says that tianeptine and amineptine are metabolised the same way...into reactive metabolites that can kill lymphocytes and damage the liver in people who are sensitive. It is thought there is some genetic predisposition involved and it is some sort of immunoallergic response.
Survector (amineptine) was pulled off the market because of hepatotoxicity (toxic to the liver). I have read cases of people developing hepatitis after taking tianeptine for 8 weeks. Apparently it can cause other liver problems too, but I am not sure how rare or common this is.
Is tianeptine really any safer than Survector (amineptine)? I suppose I could have regular liver function tests done for peace of mind. This is the only antidepressant I've been able to tolerate and it doesn't have any sexual side effects.
Posted by SLS on April 16, 2005, at 17:43:00
In reply to Re: Any drugs reduce cortisol? » sukarno, posted by rod on April 14, 2005, at 8:16:40
Mifepristone
Ketoconazole
Metyrapone
Aminoglutethimide
Posted by Festus on April 17, 2005, at 0:13:45
In reply to Re: Any drugs reduce cortisol?, posted by SLS on April 16, 2005, at 17:43:00
The most popular and probably safest thing would be a combonation of:
Phosphadyslerine caps
clean air(use filter in home)
a basic Paleolithic Diet with a lot of raw,fibrous foods(scrubbed clean)
30-45 min. of vigorous exercise 5-6 days a week
This ain,t meant to be no joke.It,s a fact,Jack! Festus
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