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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by linkadge on February 7, 2004, at 19:57:25
Are there any amino acid precursors to the endorphens. Other than exercise, are there any ways to increase body endorphen leveles.
Linkadge
Posted by rod on February 8, 2004, at 5:09:14
In reply to endorphin precursors, posted by linkadge on February 7, 2004, at 19:57:25
The first thing that comes into my mind is Amantadine. I dont know anything about endorphine precursors.
"Possible use of amantadine in depression."
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10333162&dopt=Abstract"... and seems to raise beta-endorphin/beta-lipotropin levels ..."
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Possible use of amantadine in depression.Huber TJ, Dietrich DE, Emrich HM.
Department of Clinical Psychiatry, Medical School of Hanover, Germany.
Amantadine, originally used in the treatment and prophylaxis of influenza infection, has also proved beneficial in drug-induced Parkinsonism, Parkinson's disease, traumatic head injury, dementia, multiple sclerosis and cocaine withdrawal. Amantadine appears to act through several pharmacological mechanisms, none of which has been identified as the one chief mode of action. It is a dopaminergic, noradrenergic and serotonergic substance, blocks monoaminoxidase A and NMDA receptors, and seems to raise beta-endorphin/beta-lipotropin levels. However, it is still uncertain which of these actions are relevant in therapeutic doses. One new aspect is the antiviral effect of amantadine on Borna disease virus, which it is suspected may possibly play a role in affective disorders. All of these actions could constitute an antidepressant property, and it is suggested that amantadine might work as an antidepressant not through one, but through several mechanisms thought to be related to antidepressant activity. Effects of amantadine on symptoms of affective disorders have been demonstrated in several trials administering it for varying purposes. Additionally, animal studies as well as clinical trials in humans have hinted at an antidepressant activity of amantadine. We present here an overview of the current data. However, only a limited body of evidence is available, and further studies are needed to investigate the efficacy of amantadine as well as its modes of action in depression.
Roland
Posted by Chairman_MAO on February 8, 2004, at 9:56:56
In reply to endorphin precursors, posted by linkadge on February 7, 2004, at 19:57:25
D-phenylalanine has an effect on the endorphin system, AFAIK, although I think it might be an enkephalinase inhibitor, not a precursor.
Posted by djmmm on February 8, 2004, at 17:21:20
In reply to endorphin precursors, posted by linkadge on February 7, 2004, at 19:57:25
> Are there any amino acid precursors to the endorphens. Other than exercise, are there any ways to increase body endorphen leveles.
>
>
>
> LinkadgeLow doses of TCA's raise endorphin levels
DLPA raises endorphin leves..FWIW, Nardil raises levels of phenylalanine, and most antidepressant raise endorphins (thus their use in chronic pain syndromes)simple things like Fat (from food), accupunture, deep tissue massage, falling in love, listening to music...all raise endorphin levels...
as far as a "precursor"...I would stick with something like DLPA
Posted by omegon on February 9, 2004, at 18:19:43
In reply to Re: endorphin precursors, posted by djmmm on February 8, 2004, at 17:21:20
> simple things like ... falling in love, listening to music... all raise endorphin levels...
Very simple! Thanks, I must try these!
Posted by Dr. Bob on February 9, 2004, at 22:10:10
In reply to endorphin precursors, posted by linkadge on February 7, 2004, at 19:57:25
> Are there any amino acid precursors to the endorphens.
I'd like to redirect this thread to Psycho-Babble Alternative. Here's a link:
http://www.dr-bob.org/babble/alter/20040110/msgs/311493.html
Thanks,
Bob
This is the end of the thread.
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