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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by jparsell82 on February 9, 2004, at 18:14:14
Anyone know of a med that blocks norepinephrine without having affinity for serotonin or dopamine?
Posted by Chairman_MAO on February 9, 2004, at 18:27:30
In reply to NE blocker or reuptake accelerator??, posted by jparsell82 on February 9, 2004, at 18:14:14
Atomoxetine, Reboxetine, desipramine, maprotiline
Posted by Sad Panda on February 9, 2004, at 23:25:23
In reply to NE blocker or reuptake accelerator??, posted by jparsell82 on February 9, 2004, at 18:14:14
> Anyone know of a med that blocks norepinephrine without having affinity for serotonin or dopamine?
>Doxepin too. Nortriptyline is a weak Serotoin reuptake inhibitor.
Cheers,
Panda.
Posted by linkadge on February 10, 2004, at 8:57:04
In reply to Re: NE blocker or reuptake accelerator?? » jparsell82, posted by Sad Panda on February 9, 2004, at 23:25:23
by reputake accellerator I assume you want something similar to tianeptine, in the norepinephrine rhelm. Ie something that ?lowers? norepinephrine.
Clondine does this fairly selectively.
Linkadge
Posted by jparsell82 on February 10, 2004, at 19:01:49
In reply to Re: NE blocker or reuptake accelerator??, posted by linkadge on February 10, 2004, at 8:57:04
Yeah, I meant accelerator not inhibitor. I recently ordered some Clonidine. I'd like to see what it does. Reason being, recently I gave Remeron a trial(at bedtime). When I awoke in the mornings I was manic... dysphorically. I was extremely irritated, agitated, angry at people, unhappy, etc. I'm like this normally, but Remeron seemed to double this effect. Remeron antagonizes the alpha2-adrenergic receptors doesn't it? Clonidine does the opposite?
Posted by Shawn. T. on February 10, 2004, at 22:07:51
In reply to Re: NE blocker or reuptake accelerator??, posted by jparsell82 on February 10, 2004, at 19:01:49
Clonidine is a partial agonist at norepinephrine alpha-2 receptors and an agonist at imidazoline I1 receptors. It has also been shown to exhibit weak agonist activity at norepinephrine alpha-1 receptors.
Shawn
This is the end of the thread.
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