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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by btnd on September 29, 2003, at 2:34:16
Both Risperdal and Amisulpride are D2 antagonists. Amisulpride at lower doses (25-100mg) increases presynaptic dopamine. But what is the mechanism of action of Risperdal?
The reason I'm asking is because Amisulpride has been simply wonderful for my anxiety/social phobia, and my brother, who shows pretty much same symptoms as me, has been prescribed Risperdal. Would it help his social phobia/anxiety/slight dysthymia?
Posted by jonh kimble on September 29, 2003, at 16:10:44
In reply to Is Risperdal dopaminergic like Amisulpride?, posted by btnd on September 29, 2003, at 2:34:16
I dont think risperdal has the selective presynaptic blockage at low doses that the benzimides do (amisulpride). but please dont just listen to me, i could be wrong
Posted by btnd on September 30, 2003, at 8:21:33
In reply to Re: Is Risperdal dopaminergic like Amisulpride?, posted by jonh kimble on September 29, 2003, at 16:10:44
> I dont think risperdal has the selective presynaptic blockage at low doses that the benzimides do (amisulpride). but please dont just listen to me, i could be wrong
Here are some old posts from this site:(Risperidone=D2 antagonist + 5HT2 antagonist)
"I can't comment on Serzone, as I don't have much of a feel for this drug. It may be the one serotonergic drug that yields an immediate increase in dopaminergic neurotransmission by acting as a 5-HT2 antagonist. 5-HT2 antagonists seem to promote an increase in the activity (dopamine release) within the prefrontal cortex, a region considered important for the perception of mood and motivation. Disturbances in this area often produces apathy. The atypical neuroleptics also potently block 5-HT2 receptors, and this action is thought to be responsible for their ability to improve the negative vegetative symptoms (depression-like) of schizophrenia."
and the study:Some behavioural effects of risperidone
in rats: comparison with haloperidolABSTRACT
Risperidone is a dopaminergic as well as a 5-HT2 antagonist. The drug was found to exert beneficial effects on both positive and negative symptoms of schizophrenia. Since recently, schizophrenia is regarded as a composite of not only positive and negative but also affective and cognitive symptoms, in this study the effects of risperidone compared with typical neuroleptic haloperidol, on affective and cognitive functions were investigated in rats (anxiolytic, antidepressive and memory tests). We found, that in contrast to haloperidol, risperidone had antidepressive, anxiolytic and memory enhancing effects. The results obtained correspond with favourable effects of risperidone on mood disturbances and cognitive functions of schizophrenic patients observed under clinical conditions.
This is the end of the thread.
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