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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by linkadge on September 23, 2003, at 20:15:20
I've heard many people around here say things like Effexor is an SSRI in small doses, and then is an SNRI at higher doses.
This makes no sence at all. Effexor blocks the reputake of serotonin and norepinephrine in a certain ratio, dose dependantly.
Even if you only take 37.5 mg of Effexor, you are still getting a certain reputake of serotonin and a certain reputake of norepinephrine. Effexor is an SNRI at all doses.
The issue comes when describing the effects of Effexor. For me, and some others, Effexor is quite stimulating even at 37.5mg. For others (who may have a lower norepinephrine to begin with) they may need higher doses to achieve adequate norepinephrine reputake inhibition.
But saying things like Effexor has no effect on Norephinephrine until 225mg's makes no sence. If the molecue has affinity for norepinephrine reputake sites then it will increase norepinephrine levels dose dependantly.
I agree the effects of the drug are dependant on the person. Some say it makes them drowsy, but I couldn't keep still on the stuff.
Linkadge
Posted by Ramon Paz on September 23, 2003, at 20:31:12
In reply to Effexor SSRI/SNRI nonsense, posted by linkadge on September 23, 2003, at 20:15:20
> I've heard many people around here say things like Effexor is an SSRI in small doses, and then is an SNRI at higher doses.
>
> This makes no sence at all. Effexor blocks the reputake of serotonin and norepinephrine in a certain ratio, dose dependantly.
>
> Even if you only take 37.5 mg of Effexor, you are still getting a certain reputake of serotonin and a certain reputake of norepinephrine. Effexor is an SNRI at all doses.
>
> The issue comes when describing the effects of Effexor. For me, and some others, Effexor is quite stimulating even at 37.5mg. For others (who may have a lower norepinephrine to begin with) they may need higher doses to achieve adequate norepinephrine reputake inhibition.
>
> But saying things like Effexor has no effect on Norephinephrine until 225mg's makes no sence. If the molecue has affinity for norepinephrine reputake sites then it will increase norepinephrine levels dose dependantly.
>
> I agree the effects of the drug are dependant on the person. Some say it makes them drowsy, but I couldn't keep still on the stuff.
>
> LinkadgeEffexor is classificated as SNRI, so it is SNRI.
What you said about noradrenergic and even dopaminergic effects is right. But if you're tanking 75mg you wont fell norad effecs so the designation used. Did I say a bullshit?
I read(just read) the proportion is 10:5:1 seroton,norad,and dopaminergic. (milnacilpran is 1:1)
Posted by linkadge on September 24, 2003, at 7:59:13
In reply to Re: Effexor SSRI/SNRI nonsense, posted by Ramon Paz on September 23, 2003, at 20:31:12
But even that is not *necessarily* true.
I felt the noradrenic effects even at
37.5 my heart was racing (someting that
no ssri did). There was another who had
a similar experience (was it cybercafe?)Anyhow what I meant to say was that
for some, the noradrenic effect is
existant even at 37.5Linkadge
Posted by Kacy on September 24, 2003, at 19:20:54
In reply to Re: Effexor SSRI/SNRI nonsense, posted by linkadge on September 24, 2003, at 7:59:13
I went up to 225 mg of Effexor and never felt anything that I could think was norepinephrine. It's not energizing for me—zero, zip, nada. There's no comparison at all to Strattera. Different dopes for different folks.
Posted by DSCH on September 26, 2003, at 14:32:29
In reply to Effexor SSRI/SNRI nonsense, posted by linkadge on September 23, 2003, at 20:15:20
There are confusions in terminology...
to some people, SNRI = selective norepinepherine reuptake inhibitior (ala SSRI)
to others (Dr. Preskorn being one of them IIRC), SNRI = serotonin and norepinepherine reuptake inhibitor (thus tricyclics fall in here as well)
Velafaxine is supposed to, in the case of the "typical human", inhibit reuptake starting with serotonin at low dose and gradually taking in norepinepherine and finally dopamine as well at the highest theraeutic dose. Of course, YMMV!
This is the end of the thread.
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