Psycho-Babble Medication Thread 257611

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

Matt DDS

Posted by Budgie on September 6, 2003, at 15:06:20

Hey Matt,

It's been a while. How's everything going for you? Still having success?

I just bumped up the Parnate to 40mg. Have you had a hard time when you increase the dosage? My body's having a rough time getting used to it, but I realize that it eventually will. I also realize that the physical reactions I'm having- sedation, muscle stiffness, general crappy feeling- are eactly the same as I had for the first week that I started. So I think you (and cubbybear?) were right- it never was any kind of hypertensive reaction, just my body getting used it the med. Actually, I can tell now, too, that's it's really hyPOtension that I'm feeling.

So I guess ham is back in!

All in all, this med is doing wonders for me. I'm thinking 40mg will be a good dose for a while.

Talk to you soon,
Chris

 

Parnate and spontaneous hypertensive episodes :( » Budgie

Posted by mattdds on September 6, 2003, at 15:53:09

In reply to Matt DDS, posted by Budgie on September 6, 2003, at 15:06:20

Hey Chris,

I had the lamest thing happen with Parnate this week. Just when I felt it was starting to work (and it became pretty obvious it was), I started getting spontaneous hypertension. This was not diet related, as I was strictly obeying the diet, and I would sometimes get these while fasting. But my BP would get up to around 170/105, which was pretty scary. It took a few hours to go down each night, and I would be taking my pressure every 1/2 hour to monitor it. It seemed to stabilize at that, so I never went to the ER or took nifedipine (although I do have some). Each time, it would go down without treatment. I wouldn't call these "crises", but perhaps "urgencies".
Others that used to post here, I believe, have had similar experiences. It seems more common with Parnate than Nardil. It's really too bad, because it's a damn good med! It's not common for this reaction to happen, but not unheard of either. Some people think Parnate (or one of its metabolites) has an innate pressor effect. This would make sense, because the structure is very similar to that of amphetamine (although it does NOT get converted to amphetamine in the body).

So I decided to scale down to 20mg and then to 10mg. I go to the doc on Tuesday to see what to do. Right now, I'm just taking one in the morning, as opposed to the four divided doses. Perhaps I ramped up too fast?

I am really bummed. Parnate seemed to really be doing the job, but had that unfortunate, and somewhat alarming effect of spiking my BP.

I hear Nardil is less likely to do this. So maybe I can get my doc to let me try it. Or even better, he may have some solutions to the BP problem with Parnate.

Another weird note. Yes, HYPOtension is more common with this, and generally my BP would run significantly lower, especially the diastolic. But consistently for a couple hours each night, it would shoot up!

I'm glad you're having success with it. On 40mg I was really starting to see a difference. I doubt you'll get the same reaction I did, it's rather rare. Consider yourself lucky!

Best of luck!

Matt

 

Re: spontaneous hypertensive episodes

Posted by Questionmark on September 7, 2003, at 22:55:02

In reply to Parnate and spontaneous hypertensive episodes :( » Budgie, posted by mattdds on September 6, 2003, at 15:53:09

It's possible you "ramped up too fast." Not sure.
Yeah Nardil definitely seems much less likely to cause spontaneous hypertension than Parnate. So definitely don't give up hope on Nardil before you try it-- if you find the Parnate too difficult. good luck.

 

Re: spontaneous hypertensive episodes » Questionmark

Posted by mattdds on September 7, 2003, at 23:45:55

In reply to Re: spontaneous hypertensive episodes, posted by Questionmark on September 7, 2003, at 22:55:02

Hi,

Thanks, I'm not too worried.

Another thing I've read regarding Nardil, is that it's less likely to create food-induced hypertensive crises than Parnate (i.e. it takes more mg of tyramine to induce a response when on Nardil than on Parnate, in one study I read). Do you know anything about this?

I thought I was through with AD's before Parnate. SSRI's and TCA's of all flavors were HELL. But my response to Parnate was so good that I definitely will discuss Nardil with my doc on Tuesday (or see what he says about Parnate and the BP thingy).

I really will miss Parnate's lack of sexual side effects. Actually, it was a bit *prosexual*, at least for me.

Benzos have been so good for me. Perhaps Nardil will be good for me too with the whole GABA transaminase inhibition, as well as the MAO inhibition.

Is Nardil another Paxil (am I going to have a heart attack before I finally have an orgasm)? Or Are the sexual SE's not quite so bad? I've heard Nardil is not as bad as the SSRI's.

Thanks for your response!

Matt

 

Re: Parnate and spontaneous hypertensive episodes :(

Posted by Budgie on September 8, 2003, at 10:08:01

In reply to Parnate and spontaneous hypertensive episodes :( » Budgie, posted by mattdds on September 6, 2003, at 15:53:09

Matt,

That truly sucks, especially when it was doing you so much good. Maybe it'll just be a dosing issue- you've been taking too much at once or too close together. I definitely notice something (and to be honest, I don't know whether my BP is up or down. I really have to get a monitor) when I take my doses too close together. My heart starts beating really hard (not so much fast), I feel super light-headed, and I just lose all strength in my muscles. Walking up the hill to my house can be exhausting! Is this at all like what you experienced? I've only had these effects A. when I first started the med, and B. when I just increased the dose last week.

Would you still take the Klonopin with the Nardil? Do you think that would be really sedating? I think the thing I would miss about this med more than anything is the increased cognitive effects, the mental energy- it's why I was reluctant to try Nardil in the first place.

I really hope you get it all straightened out. It really bummed me when I read your message.

Good luck, though, and keep us posted.

Chris

Oh yeah, what is a "pressor" effect?

> Hey Chris,
>
> I had the lamest thing happen with Parnate this week. Just when I felt it was starting to work (and it became pretty obvious it was), I started getting spontaneous hypertension. This was not diet related, as I was strictly obeying the diet, and I would sometimes get these while fasting. But my BP would get up to around 170/105, which was pretty scary. It took a few hours to go down each night, and I would be taking my pressure every 1/2 hour to monitor it. It seemed to stabilize at that, so I never went to the ER or took nifedipine (although I do have some). Each time, it would go down without treatment. I wouldn't call these "crises", but perhaps "urgencies".
> Others that used to post here, I believe, have had similar experiences. It seems more common with Parnate than Nardil. It's really too bad, because it's a damn good med! It's not common for this reaction to happen, but not unheard of either. Some people think Parnate (or one of its metabolites) has an innate pressor effect. This would make sense, because the structure is very similar to that of amphetamine (although it does NOT get converted to amphetamine in the body).
>
> So I decided to scale down to 20mg and then to 10mg. I go to the doc on Tuesday to see what to do. Right now, I'm just taking one in the morning, as opposed to the four divided doses. Perhaps I ramped up too fast?
>
> I am really bummed. Parnate seemed to really be doing the job, but had that unfortunate, and somewhat alarming effect of spiking my BP.
>
> I hear Nardil is less likely to do this. So maybe I can get my doc to let me try it. Or even better, he may have some solutions to the BP problem with Parnate.
>
> Another weird note. Yes, HYPOtension is more common with this, and generally my BP would run significantly lower, especially the diastolic. But consistently for a couple hours each night, it would shoot up!
>
> I'm glad you're having success with it. On 40mg I was really starting to see a difference. I doubt you'll get the same reaction I did, it's rather rare. Consider yourself lucky!
>
> Best of luck!
>
> Matt
>

 

Re: spontaneous hypertensive episodes

Posted by Questionmark on September 9, 2003, at 20:21:48

In reply to Re: spontaneous hypertensive episodes » Questionmark, posted by mattdds on September 7, 2003, at 23:45:55

> Hi,
>
> Thanks, I'm not too worried.
>
> Another thing I've read regarding Nardil, is that it's less likely to create food-induced hypertensive crises than Parnate (i.e. it takes more mg of tyramine to induce a response when on Nardil than on Parnate, in one study I read). Do you know anything about this?
>
> I thought I was through with AD's before Parnate. SSRI's and TCA's of all flavors were HELL. But my response to Parnate was so good that I definitely will discuss Nardil with my doc on Tuesday (or see what he says about Parnate and the BP thingy).
>
> I really will miss Parnate's lack of sexual side effects. Actually, it was a bit *prosexual*, at least for me.
>
> Benzos have been so good for me. Perhaps Nardil will be good for me too with the whole GABA transaminase inhibition, as well as the MAO inhibition.
>
> Is Nardil another Paxil (am I going to have a heart attack before I finally have an orgasm)? Or Are the sexual SE's not quite so bad? I've heard Nardil is not as bad as the SSRI's.
>
> Thanks for your response!
>
> Matt

i don't think Nardil is as bad as the SSRIs in that respect. But it's still pretty bad-- though not for everyone.


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.