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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by jrbecker on June 20, 2003, at 11:06:42
I know some of you in the atypical camp have already tried chromium p (w/ mixed results), but this seemed interesting nonetheless...
New Study Finds Chromium Picolinate and Conjugated Linoleic Acid Combination Enhances Muscle Glycogen Production
Monday June 16, 1:47 pm ET
Results from University of Vermont Medical College/Nutrition 21 Study Presented at American Diabetes Association Scientific Sessions
NEW ORLEANS--(BUSINESS WIRE)--June 16, 2003-- (Nutrition 21, Inc. Nasdaq: NXXI) - The results of a new study found the novel combination of chromium picolinate and conjugated linoleic acid (CLA) increased muscle glycogen levels -- a measure of the body's ability to process stored glucose, which contributes to physical strength and endurance.
The findings were presented Saturday, June 14 at the American Diabetes Association (ADA) 63rd Scientific Sessions in New Orleans by Dr. Vijaya Juturu, Nutrition 21, Inc. researcher, who collaborated with the University of Vermont Medical College on the study.Chromium picolinate and CLA have independently shown benefits in improving glucose uptake in insulin-stimulated cells. The new study evaluated the effects of the nutrient combination on glycogen in human skeletal muscle cells. Researchers found that the combination of chromium picolinate and CLA significantly enhanced insulin-stimulated muscle glycogen production, more than when each was used alone.
"These results build upon previous studies showing that the combination of chromium picolinate and CLA has significant benefits in enhancing carbohydrate metabolism," states James Komorowski, MS, Vice President of Technical Services and Scientific Affairs, Nutrition 21, Inc. "Enhancement in muscle glycogen levels is important for endurance, body building, and muscle recovery."
The research was supported by an unrestricted grant to the University of Vermont Medical College from Nutrition 21, Inc. Nutrition 21's novel combination of Chromax® chromium picolinate and CLA, known as Zenergen®, was used in the study.
"This research is part of Nutrition 21's continued commitment to further validate the potential of chromium picolinate - individually and in novel ingredient combinations - as a nutritional supplement to enhance insulin function," said Gail Montgomery, president and CEO. "The potential of Zenergen shows promise as a safe and effective supplement for active, health-conscious Americans."
Chromium is an essential mineral that is a co-factor of insulin. Chromax chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism.
About Nutrition 21
Nutrition 21 is a leading developer and provider of nutritional products whose health benefits are substantiated by clinical research. The Company markets Chromax chromium picolinate, the leading brand of chromium, and holds 35 patents for nutrition products, 22 for chromium compounds and their uses. More information is available at www.nutrition21.com.
http://biz.yahoo.com/bw/030616/165785_1.html
Posted by samplemethod on June 20, 2003, at 13:12:10
In reply to Chromium Picolinate combo increases glycogen prod, posted by jrbecker on June 20, 2003, at 11:06:42
Im thinking of trying chromium. Myabe not the picolinate one which tests have shown to be bad for your cells in some way that I cant remember.
Whats this chromium gtf stuff... have u guys tried, wat ya think about it?
> I know some of you in the atypical camp have already tried chromium p (w/ mixed results), but this seemed interesting nonetheless...
>
> New Study Finds Chromium Picolinate and Conjugated Linoleic Acid Combination Enhances Muscle Glycogen Production
>
> Monday June 16, 1:47 pm ET
> Results from University of Vermont Medical College/Nutrition 21 Study Presented at American Diabetes Association Scientific Sessions
>
>
> NEW ORLEANS--(BUSINESS WIRE)--June 16, 2003-- (Nutrition 21, Inc. Nasdaq: NXXI) - The results of a new study found the novel combination of chromium picolinate and conjugated linoleic acid (CLA) increased muscle glycogen levels -- a measure of the body's ability to process stored glucose, which contributes to physical strength and endurance.
> The findings were presented Saturday, June 14 at the American Diabetes Association (ADA) 63rd Scientific Sessions in New Orleans by Dr. Vijaya Juturu, Nutrition 21, Inc. researcher, who collaborated with the University of Vermont Medical College on the study.
>
> Chromium picolinate and CLA have independently shown benefits in improving glucose uptake in insulin-stimulated cells. The new study evaluated the effects of the nutrient combination on glycogen in human skeletal muscle cells. Researchers found that the combination of chromium picolinate and CLA significantly enhanced insulin-stimulated muscle glycogen production, more than when each was used alone.
>
> "These results build upon previous studies showing that the combination of chromium picolinate and CLA has significant benefits in enhancing carbohydrate metabolism," states James Komorowski, MS, Vice President of Technical Services and Scientific Affairs, Nutrition 21, Inc. "Enhancement in muscle glycogen levels is important for endurance, body building, and muscle recovery."
>
> The research was supported by an unrestricted grant to the University of Vermont Medical College from Nutrition 21, Inc. Nutrition 21's novel combination of Chromax® chromium picolinate and CLA, known as Zenergen®, was used in the study.
>
> "This research is part of Nutrition 21's continued commitment to further validate the potential of chromium picolinate - individually and in novel ingredient combinations - as a nutritional supplement to enhance insulin function," said Gail Montgomery, president and CEO. "The potential of Zenergen shows promise as a safe and effective supplement for active, health-conscious Americans."
>
> Chromium is an essential mineral that is a co-factor of insulin. Chromax chromium picolinate is the most clinically tested brand of chromium with proven efficacy for support of glucose metabolism.
>
> About Nutrition 21
>
> Nutrition 21 is a leading developer and provider of nutritional products whose health benefits are substantiated by clinical research. The Company markets Chromax chromium picolinate, the leading brand of chromium, and holds 35 patents for nutrition products, 22 for chromium compounds and their uses. More information is available at www.nutrition21.com.
>
> http://biz.yahoo.com/bw/030616/165785_1.html
>
>
>
Posted by noa on June 20, 2003, at 19:48:21
In reply to Re: Chromium Picolinate combo increases glycogen prod, posted by samplemethod on June 20, 2003, at 13:12:10
I take chromium picolinate.
If you can locate the studies that show chromium picolinate to be bad for cells (or was it DNA someone posted about), please provide the link. I had mentioned to my pdoc that someone here had heard that from their pharmacist and he asked me to get the reference because he hadn't seen it.
Posted by Larry Hoover on June 20, 2003, at 20:31:58
In reply to Re: Chromium Picolinate combo increases glycogen prod, posted by noa on June 20, 2003, at 19:48:21
> I take chromium picolinate.
>
> If you can locate the studies that show chromium picolinate to be bad for cells (or was it DNA someone posted about), please provide the link. I had mentioned to my pdoc that someone here had heard that from their pharmacist and he asked me to get the reference because he hadn't seen it.Looks like chromium picolinate can have adverse effects not seen in other chromium(III) salts, like the nicotinate or chloride. I didn't know about this before.....I like these questions people ask.
Lar
Cytotoxicity and oxidative mechanisms of different forms of chromium.
Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG.
Department of Pharmacy Sciences, Creighton University School of Pharmacy and Health Professions, 2500 California Plaza, Omaha, NE 68178, USA. debsis@creighton.edu
Chromium exists mostly in two valence states in nature: hexavalent chromium [chromium(VI)] and trivalent chromium [chromium(III)]. Chromium(VI) is commonly used in industrial chrome plating, welding, painting, metal finishes, steel manufacturing, alloy, cast iron and wood treatment, and is a proven toxin, mutagen and carcinogen. The mechanistic cytotoxicity of chromium(VI) is not completely understood, however, a large number of studies demonstrated that chromium(VI) induces oxidative stress, DNA damage, apoptotic cell death and altered gene expression. Conversely, chromium(III) is essential for proper insulin function and is required for normal protein, fat and carbohydrate metabolism, and is acknowledged as a dietary supplement. In this paper, comparative concentration- and time-dependent effects of chromium(VI) and chromium(III) were demonstrated on increased production of reactive oxygen species (ROS) and lipid peroxidation, enhanced excretion of urinary lipid metabolites, DNA fragmentation and apoptotic cell death in both in vitro and in vivo models. Chromium(VI) demonstrated significantly higher toxicity as compared with chromium(III). To evaluate the role of p53 gene, the dose-dependent effects of chromium(VI) were assessed in female C57BL/6Ntac and p53-deficient C57BL/6TSG p53 mice on enhanced production of ROS, lipid peroxidation and DNA fragmentation in hepatic and brain tissues. Chromium(VI) induced more pronounced oxidative damage in multiple target organs in p53 deficient mice. Comparative studies of chromium(III) picolinate and niacin-bound chromium(III), two popular dietary supplements, reveal that chromium(III) picolinate produces significantly more oxidative stress and DNA damage. Studies have implicated the toxicity of chromium picolinate in renal impairment, skin blisters and pustules, anemia, hemolysis, tissue edema, liver dysfunction; neuronal cell injury, impaired cognitive, perceptual and motor activity; enhanced production of hydroxyl radicals, chromosomal aberration, depletion of antioxidant enzymes, and DNA damage. Recently, chromium picolinate has been shown to be mutagenic and picolinic acid moiety appears to be responsible as studies show that picolinic acid alone is clastogenic. Niacin-bound chromium(III) has been demonstrated to be more bioavailable and efficacious and no toxicity has been reported. In summary, these studies demonstrate that a cascade of cellular events including oxidative stress, genomic DNA damage and modulation of apoptotic regulatory gene p53 are involved in chromium(VI)-induced toxicity and carcinogenesis. The safety of chromium(III) is largely dependent on the ligand, and adequate clinical studies are warranted to demonstrate the safety and efficacy of chromium(III) for human consumption.
FASEB J. 1995 Dec;9(15):1643-8.
Chromium(III) picolinate produces chromosome damage in Chinese hamster ovary cells.
Stearns DM, Wise JP Sr, Patierno SR, Wetterhahn KE.
Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755-3564, USA.
Chromium(III) complexes currently being sold as dietary supplements were tested for their ability to cause chromosomal aberrations in Chinese hamster ovary cells. Complexes were tested in soluble and particulate forms. Chromium picolinate was found to produce chromosome damage 3-fold to 18-fold above control levels for soluble doses of 0.050, 0.10, 0.50, and 1.0 mM after 24 h treatment. Particulate chromium picolinate doses of 8.0 micrograms/cm2 (corresponding to a 0.10 mM solublized dose) and 40 micrograms/cm2 (0.50 mM) produced aberrations 4-fold and 16-fold above control levels, respectively. Toxicity was measured as a decrease in plating efficiency relative to controls. The above treatments produced > or = 86% survival for all doses except 1.0 mM chromium picolinate, which produced 69 +/- 10% survival. Chromium nicotinate, nicotinic acid, and chromium(III) chloride hexahydrate did not produce chromosome damage at equivalent nontoxic doses. Damage was inferred to be caused by the picolinate ligand because picolinic acid in the absence of chromium was clastogenic. Data are evaluated in terms of their relevance to human exposure based on pharmacokinetic modeling of tissue accumulation and are discussed in terms of literature reporting toxic effects of picolinic acid.
Posted by Larry Hoover on June 20, 2003, at 20:46:14
In reply to Re: Chromium Picolinate combo increases glycogen prod, posted by noa on June 20, 2003, at 19:48:21
Posted by HenryO on June 21, 2003, at 3:59:06
In reply to Re: Chromium Picolinate combo increases glycogen prod » noa, posted by Larry Hoover on June 20, 2003, at 20:31:58
So the short answer is??? Nix the chromium P and try the chromium N? and maybe add a bit of Niacin?
How do you find these references? Those are some pretty exhaustive studies. What's your secret?
Posted by Larry Hoover on June 21, 2003, at 7:34:53
In reply to Chromium nicotinate/ Larry Hoover, posted by HenryO on June 21, 2003, at 3:59:06
> So the short answer is??? Nix the chromium P and try the chromium N? and maybe add a bit of Niacin?
The added niacin isn't necessary, but yes, the short answer is nix the picolinate and go for e.g. the nicotinate.
> How do you find these references? Those are some pretty exhaustive studies. What's your secret?
Keywords. I have always been very good at research, and I think that starts with the right keywords. Plus patience, the willingness to take a thread "sideways" using "find similar pages" or "related subjects" switches (if the keywords haven't given me the selective info I was seeking).
I had those refs in less than 2 minutes, just for the record.
Lar
Posted by noa on June 21, 2003, at 10:38:12
In reply to Re: Chromium Picolinate combo increases glycogen prod » noa, posted by Larry Hoover on June 20, 2003, at 20:31:58
Thank you for the article abstracts. Could I also ask you to provide the URLs for these abstracts? Thanks.
Posted by noa on June 21, 2003, at 10:38:32
In reply to Re: Chromium nicotinate is readily available (nm) » noa, posted by Larry Hoover on June 20, 2003, at 20:46:14
Yes, I know--I've seen it as chromium polynicotinate. Thanks.
Posted by Larry Hoover on June 21, 2003, at 10:48:17
In reply to Re: Chromium Picolinate combo increases glycogen prod » Larry Hoover, posted by noa on June 21, 2003, at 10:38:12
> Thank you for the article abstracts. Could I also ask you to provide the URLs for these abstracts? Thanks.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8529845&dopt=Abstract
Welcome,
LarP.S. If you go to http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
all you need to enter is the abstract #, e.g. 8529845, and you'll get the abstract you want.It's easier that way if you have a list of abstracts to view.
Posted by noa on June 21, 2003, at 21:20:38
In reply to Re: abstract URLs » noa, posted by Larry Hoover on June 21, 2003, at 10:48:17
Posted by elleff on June 23, 2003, at 4:50:37
In reply to Re: abstract URLs--Thanks. (nm) » Larry Hoover, posted by noa on June 21, 2003, at 21:20:38
There are certainly reasons to be concerned about the potential mutagenicity and carcinogenicity of Chromium Picolinate. The UK Food Standards Agency recently called for Chromium Picolinate to be banned from usage as a food supplement, see http://www.foodstandards.gov.uk/news/pressreleases/vitsandminspress
It's a pity because I've heard of people having good responses to it. Chromium polynicotinate and yeast extract chromium ("GTF Chromium") may work just as well - any experience with these?
elleff
Posted by Larry Hoover on June 23, 2003, at 8:03:49
In reply to Re: Chromium Picolinate - Mutagenicity Concerns, posted by elleff on June 23, 2003, at 4:50:37
> There are certainly reasons to be concerned about the potential mutagenicity and carcinogenicity of Chromium Picolinate. The UK Food Standards Agency recently called for Chromium Picolinate to be banned from usage as a food supplement, see http://www.foodstandards.gov.uk/news/pressreleases/vitsandminspress
Thanks for the ref. The Brits are definitely well protected by their government agencies.
Did you see this link, further down the page, to a summary article about acceptable nutrient intakes....?
http://www.foodstandards.gov.uk/multimedia/pdfs/vitmin2003.pdf
Very nicely done. It's a big file, but it's on a high-speed server, so it downloads quite quickly.
>
> It's a pity because I've heard of people having good responses to it. Chromium polynicotinate and yeast extract chromium ("GTF Chromium") may work just as well - any experience with these?
>
> elleffScientific evidence is that other forms of chromium supps work just fine for control of blood sugar, etc. I'll be switching to the polynicotinate, myself.
Lar
Posted by elleff on June 23, 2003, at 17:36:04
In reply to Re: Chromium Picolinate - Mutagenicity Concerns » elleff, posted by Larry Hoover on June 23, 2003, at 8:03:49
> Thanks for the ref. The Brits are definitely well protected by their government agencies.
>
> Did you see this link, further down the page, to a summary article about acceptable nutrient intakes....?
>
> http://www.foodstandards.gov.uk/multimedia/pdfs/vitmin2003.pdf
>
> Very nicely done. It's a big file, but it's on a high-speed server, so it downloads quite quickly.Yes thanks, I downloaded this and agree that it's an excellent summary of the whole vitamin and mineral supplement area.
> Scientific evidence is that other forms of chromium supps work just fine for control of blood sugar, etc. I'll be switching to the polynicotinate, myself.
>
> LarI'd be interested in hearing whether you feel it has any mood improving effects.
elleff
Posted by noa on June 23, 2003, at 20:21:43
In reply to Re: Chromium Picolinate - Mutagenicity Concerns, posted by elleff on June 23, 2003, at 17:36:04
This is the end of the thread.
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