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Dr. Bob is Robert Hsiung, MD,
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Posted by BekkaH on March 11, 2003, at 23:29:38
In reply to Re: Cymbalta/Duloxetine--Something's Up » SLS, posted by Ritch on March 11, 2003, at 23:12:55
Ritch, Lexapro is made by Forest Labs. Lilly makes Cymbalta and Strattera, etc.
Posted by Ritch on March 12, 2003, at 9:56:51
In reply to Lexapro is not from Lilly - Ritch, posted by BekkaH on March 11, 2003, at 23:29:38
> Ritch, Lexapro is made by Forest Labs. Lilly makes Cymbalta and Strattera, etc.
>Hi Bekka, yes that is *precisely* why I mentioned that. I didn't explain my reasoning very well. I know Lilly is losing *some* money short term by having mfg. problems and delaying the introduction. But I was wondering about the *timing* of the introduction perhaps being more important for Lilly. They are aware that Forest has released Lexapro and many are being switched to it and trying it for the first time. As with many other AD's it is going to poopout for a significant minority of folks on it or after a few months not seem to be as efficacious for others. That's when they will be ready to juggle meds again. I just wonder if some delay could benefit the introduction of Cymbalta because Lexapro will have been tried enough and docs will be more willing to make a switch *from* Lexapro to Cymbalta if the docs have had more experience with Lexapro beforehand.
Posted by jrbecker on March 12, 2003, at 20:38:48
In reply to Re: Cymbalta/Duloxetine--Something's Up » SLS, posted by Ritch on March 11, 2003, at 23:12:55
I have just heard from a very reputable source that the tentative timeline for duloxetine's release is four months from now. Whether that means 'final approval' or 'time to market,' I'm not entirely sure. Although I can't reveal my source, I can tell you that he is on the Lilly advisory board for the drug.
If any of you are day traders, I want a cut of your shares if you actually buy low and sell high that week.
Posted by BekkaH on March 12, 2003, at 21:33:40
In reply to Re: Lexapro is not from Lilly - Ritch, posted by Ritch on March 12, 2003, at 9:56:51
> > > Hi Bekka, yes that is *precisely* why I mentioned that.
Oh, now I see what you mean. Thanks for the explanation.
Posted by Ritch on March 12, 2003, at 23:17:01
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on March 12, 2003, at 20:38:48
Posted by hok on March 13, 2003, at 14:19:14
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on March 12, 2003, at 20:38:48
Posted by hok on March 14, 2003, at 11:03:23
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on March 12, 2003, at 20:38:48
so we can assume that means a mid-summer release, somewhere around July?
Posted by Jack Smith on March 14, 2003, at 12:23:20
In reply to Re: Cymbalta/Duloxetine timing, posted by hok on March 14, 2003, at 11:03:23
> so we can assume that means a mid-summer release, somewhere around July?
We can't assume anything with this. Selegiline Patch. Reboxetine. Ring any bells.
Posted by hok on March 14, 2003, at 12:46:53
In reply to Re: Cymbalta/Duloxetine timing, posted by Jack Smith on March 14, 2003, at 12:23:20
pessimmism ain't good for the mind Jack. Think positive my friend. Plus, basing Cymbalta's progress on the past woes of Selegiline patch and reboxetine isn't really logical. We can only go with the info we've been given thus far, and right now it points to a summer release.
> > so we can assume that means a mid-summer release, somewhere around July?
>
> We can't assume anything with this. Selegiline Patch. Reboxetine. Ring any bells.
Posted by jrbecker on March 14, 2003, at 15:51:03
In reply to Re: Cymbalta/Duloxetine timing, posted by hok on March 14, 2003, at 12:46:53
Some of you mentioned that you are interested in being involved in a duloxetine trial. Unfortuantely, the big trial that's listed on the clinicaltrials.gov site is still not open yet. In talking to my doc, who has been involved in the Phase III trials, he mentioned that the best way to go about it is have your psychiatrist call in to the Lilly research line for you. There are supposedly trials going on that are not listed on websites. Just one more way you might be able to uncover a trial in your area.
-JRB
Posted by SLS on March 14, 2003, at 18:49:27
In reply to Re: Cymbalta/Duloxetine trials, posted by jrbecker on March 14, 2003, at 15:51:03
What about http://www.lillytrials.com/neuroscience/neuro_trials.shtml ?
Posted by hok on March 14, 2003, at 21:13:32
In reply to Re: Cymbalta/Duloxetine trials, posted by SLS on March 14, 2003, at 18:49:27
Thanks for posting this Scott. I think JRB is referring to an even larger study that has been posted on clinicaltrials.gov that has more sites than the one you listed. It includes a few more major cities and states...
Posted by jrbecker on April 8, 2003, at 19:55:31
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on March 12, 2003, at 20:38:48
The latest I've heard from the Lilly camp...August will be the month that duloxetine gets to market. Their manufacturing hold-ups are being resolved in the interim. All is going smoothly now supposedly. That's all I know, but the news is as recent as last Friday, April 4th.
JB
Posted by lansolut on April 14, 2003, at 19:03:55
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on April 8, 2003, at 19:55:31
It would be great to be able to believe the August release date. Just curious, how does one get reliable information from Lilly?
Posted by juanantoniod on April 15, 2003, at 22:13:00
In reply to Re: Cymbalta/Duloxetine timing, posted by lansolut on April 14, 2003, at 19:03:55
All you have to do is call them. Unfortunately, all they will give you is definite information. No probablies, no maybes, nothing. Which, as I write this I realize is smart on their part, but I think we planners hope for some anticipated date.
> It would be great to be able to believe the August release date. Just curious, how does one get reliable information from Lilly?
Posted by val1224 on May 14, 2003, at 14:25:44
In reply to Re: Cymbalta/Duloxetine timing, posted by lansolut on April 14, 2003, at 19:03:55
CNS Neuroscience Institute was doing at least one of the duloxetine clinical trials for Lilly. Also, I participate in the Harris Poll surveys online and about 6-8 weeks ago received a survey from them which was all about Cymbalta. It was marketing-type questions. So, it looks like they are lining up their marketing for it.
Posted by Jack Smith on May 14, 2003, at 16:10:03
In reply to Re: Cymbalta/Duloxetine timing, posted by val1224 on May 14, 2003, at 14:25:44
> CNS Neuroscience Institute was doing at least one of the duloxetine clinical trials for Lilly. Also, I participate in the Harris Poll surveys online and about 6-8 weeks ago received a survey from them which was all about Cymbalta. It was marketing-type questions. So, it looks like they are lining up their marketing for it.
I didn't quite understand your post. What are the Harris Poll surveys? Also what does the clinical trials have to do with marketing it. Thanks in advance.
JACK
Posted by johnj on May 19, 2003, at 8:35:22
In reply to Re: Cymbalta/Duloxetine timing » val1224, posted by Jack Smith on May 14, 2003, at 16:10:03
end of the 4th quarter.
Hope the link works.
Appears it won't be until end of the year....Anybody seen a more recent update on the web or by phone?
Posted by Ben Bivens on June 15, 2003, at 18:34:56
In reply to Cymbalta/Duloxetine timing appears to be, posted by johnj on May 19, 2003, at 8:35:22
> end of the 4th quarter.
> Hope the link works.
> Appears it won't be until end of the year....Anybody seen a more recent update on the web or by phone?
>
> http://biz.yahoo.com/rc/030422/health_lilly_outlook_1.htmlGuys,
I have been interviewed by Innovex who apparently has made a 5 year deal with Lilly to help them represent Duloxetine. They said marketing and sales training would begin in mid and late june 2003, but he also said that we would not begin marketing right away, just training in Indianapolis. I'm leaning toward the end of summer release. Get ready to move some assets... Don't know if that helps but I'm looking forward to communicating on this posting site if all works out for me, and establishing a base of knowledge from you all.
Posted by sarah8 on July 2, 2003, at 9:04:26
In reply to Re: Cymbalta/Duloxetine timing » lansolut, posted by juanantoniod on April 15, 2003, at 22:13:00
I recently spoke with Lilly UK who informed that duloxetine will be out end of Q4 2003 .. so November/December time.
I followed up with BI and they said the same thing!!
Does anyone know if BI will call duloxetine something other than Cymbalta?
Posted by fendleywood on July 19, 2003, at 11:59:42
In reply to Re: Cymbalta/Duloxetine timing, posted by jrbecker on March 12, 2003, at 20:38:48
> I have just heard from a very reputable source that the tentative timeline for duloxetine's release is four months from now. Whether that means 'final approval' or 'time to market,' I'm not entirely sure. Although I can't reveal my source, I can tell you that he is on the Lilly advisory board for the drug.
>
> If any of you are day traders, I want a cut of your shares if you actually buy low and sell high that week.
>
> I lasted only two weeks in a reserach study using duloxetine for fibromyalgia. I never felt worse in my life...lethargy, confusion, aches/pains, depression like I never knew before. Obviously, I was not on the placebo.
Posted by JLM on July 21, 2003, at 1:49:52
In reply to Re: Cymbalta/Duloxetine timing, posted by fendleywood on July 19, 2003, at 11:59:42
What's with all the excitement over Cymbalta? After all, its just another dual uptake inhibitor, ala Effexor.
Here were are, after 60 years of progress in neuroscience, and we're still just manipulating SE and NE.
My prediction: Cymbalta will be no more effective than any other AD on the market.
Posted by SLS on July 21, 2003, at 7:01:33
In reply to Re: Cymbalta/Duloxetine timing, posted by JLM on July 21, 2003, at 1:49:52
> My prediction: Cymbalta will be no more effective than any other AD on the market.
Maybe, but it might be more effective for YOU or ME. That is what I care about. If you know of a single person who failed to respond to one SSRI and went on to respond to another, than you will have justified the second's existence. The more tools, the better. For every new drug that becomes available, a certain percentage of previously treatment-resistant people will respond to it. That is fact.I predict that Cymbalta will be a great addition to our arsenal - at least that is my hope.
- Scott
Posted by pseudonym on July 21, 2003, at 13:44:22
In reply to Re: Cymbalta/Duloxetine timing, posted by JLM on July 21, 2003, at 1:49:52
Manipulating SE and NE is such a broad and diverse area of research. Your dismissive statement of "just manipulating SE and NE" seems to conclude that any research into these two neurotransmitters is a failed avenue of research. Wrong.
For one, duloxetine has much lower K(i) values, which indicates it prevents re-uptake much more potently than Effexor, in vivo. Furthermore, it takes a lot less of it to do so, as indicated by much lower ED-50 values. Finally, it prevents re-uptake of NE at much lower dosage levels than Effexor. The clincal trial data is also promising, but I'm not going to reiterate that here. My prediction: You're going to come back with a mea culpa in 6-9 months, and be happy to do so.
Posted by John O'Connor on October 21, 2003, at 6:03:46
In reply to Re: Cymbalta/Duloxetine timing, posted by fendleywood on July 19, 2003, at 11:59:42
> > I lasted only two weeks in a reserach study using duloxetine for fibromyalgia. I never felt worse in my life...lethargy, confusion, aches/pains, depression like I never knew before. Obviously, I was not on the placebo.
>Hey Fendleywood,
I wasn't aware that duloxetine was going to be available for any other indications besides depression and stress-urinary incontinence. I certainly hadn't heard of any potential for its use in the treatment of fibromyalgia. Who ran this study? Any idea where I'd find details/results etc.?
Cheers,
John
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