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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by deak on April 3, 2003, at 18:21:18
zyprexa goof for ocd with maoi or any tca i think at low dose. plese tel me u think if so.
Posted by linkadge on April 3, 2003, at 19:21:37
In reply to zyprexa good for ocd? i think it so.., posted by deak on April 3, 2003, at 18:21:18
OCD is characterized with low serotonin depression-like symptoms. But, many belive
the obsessions themselves are initiated by
dopamine circuits. Much like in mania, the high
dopamine-low serotonin combination makes it very hard to let things go.I would believe that zypreza alone or a zyprexa
AD combo would work well.Linkadge
Posted by McPac on April 3, 2003, at 23:17:42
In reply to OCD two sided coin, posted by linkadge on April 3, 2003, at 19:21:37
"But, many believe
the obsessions themselves are initiated by
dopamine circuits."Link, if true, would that mean that someone with ocd would want to stay away from meds that increase dopamine levels?
Thanks!
Posted by linkadge on April 4, 2003, at 7:53:23
In reply to Link, Re: OCD two sided coin, posted by McPac on April 3, 2003, at 23:17:42
Yes, depending on the med itself.
For instance, fish oil seemed to help the
compulsive feelings, but not the obsessions
themselves. St. Johns wort helped the compulsive
aspect but again, not the obsessions.Serotonin by itself helps to controll the
compulsive feelings but no the obsessions.
But - ssri's also tend to lower dopamine
over time. This is why they are effective
for OCD cause they raise Serotonin and lower
dopamine.So yes, I would personally avoid dopamine
enhancing meds, unless you think this chemical
has become unusually low for you.
Linkadge
Posted by Dinah on April 4, 2003, at 8:03:53
In reply to OCD two sided coin, posted by linkadge on April 3, 2003, at 19:21:37
That is very interesting information. I definitely want to do some research in the area.
Luvox worked beautifully on my OCD, even the obsessions (my compulsions are minimal and obsessions always predominated). But I always thought it worked through the mechanism of apathy.
I'll have to look into the dopamine connection.
Posted by linkadge on April 4, 2003, at 15:32:02
In reply to Re: OCD two sided coin » linkadge, posted by Dinah on April 4, 2003, at 8:03:53
Dopamine plays a much more complex role in the brain. Those who take dopaminergic drugs like
cocaine and or amphetamine often notice there is a greater intensity to emotion. Dopamine spices up the emotions, makes things seem interesting, but can also create powerful desires and strange drives.When in the middle of an OC episode did something like coffee intensify your expereinece ??
Linkadge
Posted by Dinah on April 4, 2003, at 16:53:23
In reply to Re: OCD two sided coin, posted by linkadge on April 4, 2003, at 15:32:02
I don't think so. Hmmm. I think they're more related to stress and sleep. With some of that unpredictability that is just part and parcel of the cyclothymia. In fact the obsessions seem to be a part of my mood cycles, and I'm starting to be able to almost predict when they might come. Well sometimes anyway.
But the rest of it really doesn't sound like me. Except for meltdowns caused by my cyclothymia, I'm pretty flat, uninteresting, and completely without spice. :) In a nervous, high strung way. Doesn't sound like I've got too much dopamine.
Posted by linkadge on April 5, 2003, at 10:21:32
In reply to Re: OCD two sided coin » linkadge, posted by Dinah on April 4, 2003, at 16:53:23
You'll find a ballence for you
Good Luck
Linkadge
This is the end of the thread.
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