Psycho-Babble Medication Thread 134883

Shown: posts 1 to 5 of 5. This is the beginning of the thread.

 

abilify...why is it causing anxiety in some folks?

Posted by highanxiety on January 7, 2003, at 18:49:20

I am interested if someone knows why this new AP would be causing this...

 

Re: abilify...why is it causing anxiety in some folks?

Posted by neetie on January 8, 2003, at 23:10:22

In reply to abilify...why is it causing anxiety in some folks?, posted by highanxiety on January 7, 2003, at 18:49:20

It modulates rather than blocks dopamine, so it probably raises dopamine in some areas of the brain, like the mesolimbic pathway, which can cause anxiety. Dopamine enhancers regularly cause anxiety.

anita

 

thanks so much for the explanation..was wondering!

Posted by highanxiety on January 9, 2003, at 12:44:18

In reply to Re: abilify...why is it causing anxiety in some folks?, posted by neetie on January 8, 2003, at 23:10:22

eom:-)

 

Re: abilify...why is it causing anxiety in some folks?

Posted by Shawn. T. on January 14, 2003, at 23:03:36

In reply to Re: abilify...why is it causing anxiety in some folks?, posted by neetie on January 8, 2003, at 23:10:22

I think that I should clarify this somewhat; neetie's explanation is basically correct, though. I believe that Abilify's actions as an antagonist (blocker) at dopamine D2 receptors in the ventral tegmentum (part of the mesolimbic pathway) are responsible for its pro- anxiety effects. Because of this effect, dopamine is increased in the nucleus accumbens septum; enhancement of dopamine's effects on D2 receptors in this region causes anxiety as well.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969883&dopt=Abstract

Shawn

 

Re: abilify...why is it causing anxiety in some folks?

Posted by cybercafe on January 15, 2003, at 11:30:15

In reply to Re: abilify...why is it causing anxiety in some folks?, posted by Shawn. T. on January 14, 2003, at 23:03:36

> I think that I should clarify this somewhat; neetie's explanation is basically correct, though. I believe that Abilify's actions as an antagonist (blocker) at dopamine D2 receptors in the ventral tegmentum (part of the mesolimbic pathway) are responsible for its pro- anxiety effects. Because of this effect, dopamine is increased in the nucleus accumbens septum; enhancement of dopamine's effects on D2 receptors in this region causes anxiety as well.
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969883&dopt=Abstract
>

shawn.... has abilify shown any indications for mood stability or ADD?


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