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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Shawn. T. on July 11, 2002, at 7:16:31
I believe that you could mix the new potent 5-HT2 antagonist M,100,907 with a 5-HT1a agonist like gepirone to achieve good effects. Nausea may cause a problem, however. Adding a 5-HT3 antagonist or using a 5-HT2/5-HT3 antagonist might solve that if it becomes a problem.
I also think mixing an SSRI and M,100,907 would be a good idea. You could improve this drug combination even more by augmenting the SSRI with pindolol during initial treatment.
Posted by Shawn. T. on July 11, 2002, at 7:17:35
In reply to Mix a 5-HT1a agonist with a 5-HT2 antagonist?, posted by Shawn. T. on July 11, 2002, at 7:16:31
http://www-np.unimaas.nl/PsyPharm/postersBAP/posterwim.html
That displays nicely why my idea is a good one.
Posted by cybercafe on July 11, 2002, at 9:14:43
In reply to Mix a 5-HT1a agonist with a 5-HT2 antagonist?, posted by Shawn. T. on July 11, 2002, at 7:16:31
> I believe that you could mix the new potent 5-HT2 antagonist M,100,907 with a 5-HT1a agonist like gepirone to achieve good effects. Nausea may cause a problem, however. Adding a 5-HT3 antagonist or using a 5-HT2/5-HT3 antagonist might solve that if it becomes a problem.
... wait a sec... if you cause the 5TH1a receptor to fire, isn't that like saying "there is too much serotonin in the synapse, please do not release more" .... which means both the presynaptic and postsynaptic neurons won't fire??
Posted by Shawn. T. on July 11, 2002, at 10:29:14
In reply to Re: Mix a 5-HT1a agonist with a 5-HT2 antagonist?, posted by cybercafe on July 11, 2002, at 9:14:43
http://www.biopsychiatry.com/gepirone.html
I'm not sure I can answer that, but I'm going to e-mail someone who I think may be able to.
Posted by cybercafe on July 12, 2002, at 0:11:44
In reply to Re: Mix a 5-HT1a agonist with a 5-HT2 antagonist?, posted by Shawn. T. on July 11, 2002, at 10:29:14
> http://www.biopsychiatry.com/gepirone.html
>
> I'm not sure I can answer that, but I'm going to e-mail someone who I think may be able to.don't worry dude --- remember you said there were postsynaptic as well as presynaptic 5HT1A receptors? ... i'm sure the agonist must be hitting the 5HT1A and alleviating depression that way (while probably decreasing the amount of serotonin in the synapse... which itself would have both depressant and anti-depressant effects) ...
Posted by Shawn. T. on July 14, 2002, at 0:45:40
In reply to Re: Mix a 5-HT1a agonist with a 5-HT2 antagonist?, posted by cybercafe on July 12, 2002, at 0:11:44
Sometimes my brain needs a rest :)
Shawn
This is the end of the thread.
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