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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Geezer on July 2, 2002, at 10:30:18
Anyone had experience augmenting Prozac (or any SSRI) with Neltrexone - I have read Lee Dante. Also experience combining an SSRI with Wellbutrin would be welcome.
Thank you.
Geezer
Posted by BLPBart on July 7, 2002, at 14:56:03
In reply to SSRI Augmentation Naltrexone or SSRI With Well. ??, posted by Geezer on July 2, 2002, at 10:30:18
I have experience with combining prozac and wellbutrin and unfortunately my experience was bad, but rare according to my pdoc. I was on prozac alone for quite a while and doing OK except for some lethargy and weight gain. My pdoc added wellbutrin SR 300 mg/day and we dropped the prozac to 10 mg/day. After a couple of months on this combination I suddenly started having very debilitating fatigue and lethargy (could barely get out of bed and sometimes slept entire days away), muscle and joint pain, irregular periods, etc. My doc had a hard time believing that the prozac had anything to do with it but these things went away when I discontinued it and stayed on the wellbutrin alone. Since then I've started seeing info in the literature about how wellbutrin can interact with the metabolism of a lot of other drugs making them concentrate in your system. I'm thinking that this is what happened to me. It turns out that prozac is also known to have a lot of drug-drug interactions so, personally, I think this is a bad combination. Some of the other SSRIs don't have the same problem with drug interactions.
Posted by Geezer on July 7, 2002, at 15:39:54
In reply to Re: SSRI Augmentation Naltrexone or SSRI With Well, posted by BLPBart on July 7, 2002, at 14:56:03
> I have experience with combining prozac and wellbutrin and unfortunately my experience was bad, but rare according to my pdoc. I was on prozac alone for quite a while and doing OK except for some lethargy and weight gain. My pdoc added wellbutrin SR 300 mg/day and we dropped the prozac to 10 mg/day. After a couple of months on this combination I suddenly started having very debilitating fatigue and lethargy (could barely get out of bed and sometimes slept entire days away), muscle and joint pain, irregular periods, etc. My doc had a hard time believing that the prozac had anything to do with it but these things went away when I discontinued it and stayed on the wellbutrin alone. Since then I've started seeing info in the literature about how wellbutrin can interact with the metabolism of a lot of other drugs making them concentrate in your system. I'm thinking that this is what happened to me. It turns out that prozac is also known to have a lot of drug-drug interactions so, personally, I think this is a bad combination. Some of the other SSRIs don't have the same problem with drug interactions.
Thanks BLPBart,
This has been a difficult process for me. About a year ago I had Prozac "poop out". It had worked for about a year and that was actually the BEST year I had ever had. Since that time I have been to 4 different pdocs.....2 diagnosed Bipolar II and 2 diagnosed Unipolar Major recurrent. My symptoms are close to yours anerga/lethergy, moderate depression. I am currently on Depakote 750mg, Lamictal 100mg, Klonopin 0.5, and Ambien 10mg. Not a very complicated mix and I should go higher on Lamictal (even with the 2 times effect from Dep. - I am well beyond the rash stage). More than anything, I am looking for some energy. Your experience with Wellbutrin alone sounds impressive. Fortunately, at this point I have a pdoc willing to be reasonable. I will mention your experience when I see him on the 15th. Thanks so much for taking the time to reply to my post. Hope you continue to due well.
Geezer
This is the end of the thread.
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