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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by dazer on April 20, 2002, at 11:06:43
Hi to all,
I do not know anything about MAOI, but i know that they could be very effective, and they work very fast.
Besides i have known that they could help people that had resulted resistant to every other SSRI and TCa.
What are MAOI most common side effects?
Which is the difference between MAOI and SSRI or TCa?
Do they provide sommnolence and drowsiness like TCa and most part of SSRI?
Thanks very much indeed for your help!
Posted by JeffH on April 22, 2002, at 16:25:14
In reply to What are MAOI's side effects?, posted by dazer on April 20, 2002, at 11:06:43
I have been on Parnate for six weeks and it has really helped after being treatment-resistant for years.
I am bothered by the side effects: drowsiness during the day and insomnia at night. For the insomnia, my doc gave me Ambien (almost unlimited refills!).
As for the drowsines during the day, I hope this will fade in time. I'm going to discuss this on my next appointment.
Good luck. MAOI's are worth the try.
Posted by Elizabeth on April 23, 2002, at 20:51:24
In reply to What are MAOI's side effects?, posted by dazer on April 20, 2002, at 11:06:43
Some common side effects of MAOIs are orthostatic hypotension (rapid drop in blood pressure upon standing, leading to dizziness), insomnia, swelling (especially in ankles), tremor, twitching, and sexual dysfunction (as with SSRIs). Nardil also sometimes causes weight gain.
MAOIs have a different mechanism of action from SSRIs and TCAs. MAOIs prevent stray (extracellular) serotonin, norepinephrine, epinephrine, and dopamine (monoamines) from being metabolized by destroying an enzyme (monoamine oxidase, or MAO) that is needed for their metabolism. TCAs and SSRIs prevent serotonin, norepinephrine, or both, from being taken up back into neurons by blocking the site where they would be taken up.
In some countries, reversible and selective MAOIs, such as moclobemide (Manerix or Aurorix) are also available. They don't actually destroy MAO, but just bind to it so that it doesn't metabolise the monoamines. They also mainly bind only to MAO-A, one of the two major subtypes of MAO.
MAOIs work rapidly for some people, but for others it can take several weeks for them to start working, like other ADs.
I hope this is helpful to you. Good luck with whatever you decide to try.
-elizabeth
Posted by dazer on April 24, 2002, at 6:42:08
In reply to Re: What are MAOI's side effects? » dazer, posted by Elizabeth on April 23, 2002, at 20:51:24
Posted by mat on April 24, 2002, at 6:58:25
In reply to Re: What are MAOI's side effects? » dazer, posted by Elizabeth on April 23, 2002, at 20:51:24
hi
in austria moclobemid is the ONLY available MAOI!mat
Posted by Elizabeth on April 24, 2002, at 23:11:04
In reply to Re: What are MAOI's side effects? » Elizabeth, posted by mat on April 24, 2002, at 6:58:25
> in austria moclobemid is the ONLY available MAOI!
That's weird! I think the irreversible MAOIs have an important place in the treatment of depression and anxiety. Moclobemide is a good first-line drug, I think, but the irreversible MAOIs (Nardil, Parnate, Marplan, etc.) often do great things for people who don't respond to anything else.
Some places in Europe have other irreversible MAOIs available, like nialamide and iproniazid, in addition to the ones that we have in the USA. (I don't know if we ever had nialamide here; iproniazid is no longer used because of the risk of liver disease. There are also other reversible MAOIs, like toloxatone and brofaromine, that I think are used in some countries.
-elizabeth
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