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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Elayne on April 2, 2002, at 7:04:10
Dr. Kramer,
Have you changed the way you use topiramate since its association with cases of acute glaucoma came to light?What do you think is the underlying mechanism that is responsible for this association?
Thanks so much for your help.
Posted by Dr. Kramer on April 2, 2002, at 12:47:39
In reply to Kramer: Topiramate and glaucoma, posted by Elayne on April 2, 2002, at 7:04:10
> Dr. Kramer,
> Have you changed the way you use topiramate since its association with cases of acute glaucoma came to light?
>
> What do you think is the underlying mechanism that is responsible for this association?
>
> Thanks so much for your help.Not really. I explain all the risks to a patient, obviously, but it's still pretty rare, and usually resolves with rapid discontinuation of the med, so if the patient or their caregiver knows to look for it, you're usually okay.
I have no idea what the mechanism is. Best guess I could make is that the fact that it's a carbonic anhydrase inhibitor, might make it cause a slight precipitate in the ocular fluid, kind of like mini kidney stones in the eye, but I don't have any data for that, i.e., I made it up.
This is the end of the thread.
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