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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Janelle on March 27, 2002, at 1:27:13
Okay, I'm going to forget about HOW the serotonin is kept in the synapse longer by SSRI's which block the reuptake of serotonin (some kind folks here have tried to explain it to me and I only got more confused than I already am!) -- my question now is when the serotonin is blocked by an SSRI and *forced* to remain in the synapse, what eventually happens to it (the serotonin that would normally have been reuptaked so to speak)???
Posted by djmmm on March 27, 2002, at 9:17:17
In reply to SSRI's: what happens to the blocked serotonin?, posted by Janelle on March 27, 2002, at 1:27:13
Not all re-uptake sites are blocked, so this action still accounts for some of the recycling of serotonin, otherwise, the enzyme monoamine oxidase-A degrades (metabolizes) serotonin
http://www.utexas.edu/research/asrec/neurotr_copy01a.movhttp://gened.emc.maricopa.edu/bio/bio181/biobk/biobooknerv.html
Posted by fachad on March 27, 2002, at 12:12:59
In reply to SSRI's: what happens to the blocked serotonin?, posted by Janelle on March 27, 2002, at 1:27:13
Q: what eventually happens to it (the serotonin that would normally have been reuptaked)
A: It is broken down and eliminated by the enzyme Monoamine Oxidase (MAO).
There are two ways the brain eliminates neurotransmitters in the synapse: re-uptake or MAO dissolving.
So, if you block either process, it stays in there longer, and does *something* which results in an AD effect.
> Okay, I'm going to forget about HOW the serotonin is kept in the synapse longer by SSRI's which block the reuptake of serotonin (some kind folks here have tried to explain it to me and I only got more confused than I already am!) -- my question now is when the serotonin is blocked by an SSRI and *forced* to remain in the synapse, what eventually happens to it (the serotonin that would normally have been reuptaked so to speak)???
Posted by Janelle on March 28, 2002, at 1:17:45
In reply to Re: SSRI's: what happens to the blocked serotonin? » Janelle, posted by fachad on March 27, 2002, at 12:12:59
This is the end of the thread.
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