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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by Hanna on December 20, 2001, at 17:43:55
Hi,
I have been on SAM-e for a little over 2 months, working my way up from 800 mg to 1600 mg. I am, for the first time, feeling physically fantastic (due to the sudden lack of AD side-effects I've had for the last 9 years) *and* I am not feeling depressed, I am sleeping well... feeling really good! I am wondering... for those who are on SAM-e, how long have you been on it? How long has it worked for you? I've heard rumors about it "pooping out" after 3 months or so. I wonder if that's a universal limit, or if it can last longer. Any thoughts? Thanks! --Hanna
Posted by PaulB on December 21, 2001, at 12:44:34
In reply to SAM-e long term effectiveness, posted by Hanna on December 20, 2001, at 17:43:55
> Hi,
> I have been on SAM-e for a little over 2 months, working my way up from 800 mg to 1600 mg. I am, for the first time, feeling physically fantastic (due to the sudden lack of AD side-effects I've had for the last 9 years) *and* I am not feeling depressed, I am sleeping well... feeling really good! I am wondering... for those who are on SAM-e, how long have you been on it? How long has it worked for you? I've heard rumors about it "pooping out" after 3 months or so. I wonder if that's a universal limit, or if it can last longer. Any thoughts? Thanks! --HannaHanna:
SAM-E, I think is a very interesting supplement. I dont think it works for everyone but I think it can do wonders for some. I read some literature on SAM-E that was all published recently when SAM-E came on the US market. Indicated, is that SAM-E helps to 'synthesise' neurotransmitters and increases the level of neurotransmitter receptors, particulalrly dopamine. I have taken it for over a year now. In increased the effectiveness of the amino acid L-Tyrosine probably about 2-fold, sadly not a potent enough combination for me though. SAM-E may increase the effectiveness of prescription AD's and I think there is no harm in using the two together, under guidance from your physician. SAM-E has been tested to be a very safe supplement which is good news to those who use it to relieve mental health problems.
As to your question, I think SAM-E may stop working for those that it does initially work. If it acts mainly to increase the synthesis of neurotrasnmitters without supportive amino-acid therapy then it could very well cease to be effective, if we take the 'monoamine hypothesis' on depression.
All I would add is that the books are great for indicating which brand of SAM-E you choose to use. A great book, and a good read is 'Stop Depression Now' by Richard Brown, M.D., Teodora Bottiglieri, PH.D. and Carol Coleman. Bottiglieri is very respected for his knowledge of SAM-E as he has and continues to extensively study the supplement in his lab. I obtained his email address and he seems to be open to questions concerning the supplement.
t.bottiglieri@baylordallas.edu
PaulB
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